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PF3D7_0922900 3-oxoacyl-[acyl-carrier-protein] reductase [ Plasmodium falciparum 3D7 ]

Gene ID: 813505, updated on 12-Sep-2024

Summary

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Gene symbol
PF3D7_0922900
Gene description
3-oxoacyl-[acyl-carrier-protein] reductase
Locus tag
PF3D7_0922900
See related
PlasmoDB:PF3D7_0922900; VEuPathDB:PF3D7_0922900
Gene type
protein coding
RNA name
3-oxoacyl-[acyl-carrier-protein] reductase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_0922900 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
5
Sequence:
Chromosome: 9; NC_004330.2 (936868..938345, complement)

Chromosome 9 - NC_004330.2Genomic Context describing neighboring genes Neighboring gene pre-mRNA-splicing factor 18, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene DNA-directed RNA polymerase II subunit RPB3, putative Neighboring gene OTU domain-containing protein, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004330.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes. van Schaijk BC, et al. Eukaryot Cell, 2014 May. PMID 24297444, Free PMC Article
  2. Deciphering the key residues in Plasmodium falciparum beta-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein. Karmodiya K, et al. FEBS J, 2008 Oct. PMID 18721141
  3. Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis. Wickramasinghe SR, et al. Biochem J, 2006 Jan 15. PMID 16225460, Free PMC Article
  4. Production and purification of refolded recombinant Plasmodium falciparum beta-ketoacyl-ACP reductase from inclusion bodies. Karmodiya K, et al. Protein Expr Purif, 2005 Jul. PMID 15939298
  5. Functional characterization of beta-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum. Pillai S, et al. Biochem Biophys Res Commun, 2003 Mar 28. PMID 12646215

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinetic analysis and studies of direct binding between PfFabG and PfACP confirmed the identification of Arg187 and Arg230 as critical residues for the PfFabG-PfACP interactions.
    Title: Deciphering the key residues in Plasmodium falciparum beta-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein.
  2. Recombinant beta-ketoacyl-ACP reductase was purified and characterized from Escherichia coli inclusion bodies.
    Title: Production and purification of refolded recombinant Plasmodium falciparum beta-ketoacyl-ACP reductase from inclusion bodies.
  3. The biochemical properties and 1.5 A (crystal structure of OAR (3-oxoacyl acyl-carrier-protein reductase, or FabG), the second reductive step in fatty acid biosynthesis and its inhibition by hexachlorophene are reported.
    Title: Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables NADPH binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables acetoacetyl-CoA reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apicoplast HDA PubMed 
located_in apicoplast IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-oxoacyl-[acyl-carrier-protein] reductase
XP_001352100.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004330.2 Reference assembly

    Range
    936868..938345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001352064.1 → XP_001352100.1  3-oxoacyl-[acyl-carrier-protein] reductase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001352100.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I0BT33, Q8I2S7, Q965D6, W7FN58
    Conserved Domains (1) summary
    cd05333
    Location:61 → 299
    BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
Nucleotide Protein
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