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PF3D7_0918000 glideosome-associated protein 50 [ Plasmodium falciparum 3D7 ]

Gene ID: 813456, updated on 30-Jul-2025
Gene symbol
PF3D7_0918000
Gene description
glideosome-associated protein 50
Locus tag
PF3D7_0918000
See related
PlasmoDB:PF3D7_0918000; VEuPathDB:PF3D7_0918000
Gene type
protein coding
RNA name
glideosome-associated protein 50
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Try the new Transcripts and proteins table
See PF3D7_0918000 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
1
Sequence:
Chromosome: 9; NC_004330.2 (742494..743684, complement)

Chromosome 9 - NC_004330.2Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene heat shock protein 70 Neighboring gene cytochrome b5-like heme/steroid binding protein, putative Neighboring gene 50S ribosomal protein L3, apicoplast, putative

Genomic Sequence:
NC_004330.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum. Bosch J, et al. J Struct Biol, 2012 Apr. PMID 22387043, Free PMC Article
  2. Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum. Yeoman JA, et al. Eukaryot Cell, 2011 Apr. PMID 21239623, Free PMC Article
  3. Secretion of an acid phosphatase provides a possible mechanism to acquire host nutrients by Plasmodium falciparum. Müller IB, et al. Cell Microbiol, 2010 May 1. PMID 20070315
  4. Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Simon N, et al. Cell Host Microbe, 2013 Jan 16. PMID 23332154
  5. Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes. Dearnley MK, et al. J Cell Sci, 2012 Apr 15. PMID 22328505

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study describes the 1.7A resolution crystal structure of the soluble GAP50 domain
    Title: Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.
  2. Data show that C-terminally tagged PfGAP50-GFP can form a complex with endogenous copies of the linker protein PfGAP45 and the myosin A tail domain-interacting protein (MTIP).
    Title: Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum.
  3. Authors show that this acid phosphatase enzyme, formerly described as anchoring glideosome-associated protein 50 (GAP50), reveals a broad substrate profile with preference for di- and triphosphates at pH 5-7.
    Title: Secretion of an acid phosphatase provides a possible mechanism to acquire host nutrients by Plasmodium falciparum.
  4. This protein is an anchor for the gliding associated protein (GAP) complex of proteins. Commonly referred to as PfGAP50, this protein is present in Plasmodium falciparum merozoites and appears to have a role in erythrocyte invasion.
    Title: A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular vesicle HDA PubMed 
located_in food vacuole HDA PubMed 
located_in inner membrane pellicle complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
glideosome-associated protein 50
XP_001352051.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004330.2 Reference assembly

    Range
    742494..743684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001352015.1 → XP_001352051.1  glideosome-associated protein 50 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001352051.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8I2X3
    UniProtKB/TrEMBL
    A0A024V7X5, A0A024VS62, A0A024VVP5, A0A024WQT9, A0A024X828, A0A0L0CWD0, A0A0L1I8Q9, A0A0L7K8W0, A0A0L7M3D7, W4II87, W4IYK2, W7FW09, W7JYT7, W7JYU0
    Conserved Domains (1) summary
    PTZ00422
    Location:1 → 394
    PTZ00422; glideosome-associated protein 50; Provisional
Nucleotide Protein
Heading Accession and Version

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