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PF3D7_0107500 Niemann-Pick type C1-related protein [ Plasmodium falciparum 3D7 ]

Gene ID: 813212, updated on 26-Jun-2025
Gene symbol
PF3D7_0107500
Gene description
Niemann-Pick type C1-related protein
Locus tag
PF3D7_0107500
See related
PlasmoDB:PF3D7_0107500; VEuPathDB:PF3D7_0107500
Gene type
protein coding
RNA name
Niemann-Pick type C1-related protein
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PF3D7_0107500 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
4
Sequence:
Chromosome: 1; NC_004325.2 (304362..309257, complement)

Chromosome 1 - NC_004325.2Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene ATP synthase-associated protein, putative Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 2, putative Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST3/OST6, putative

Genomic Sequence:
NC_004325.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis. Istvan ES, et al. Elife, 2019 Mar 19. PMID 30888318, Free PMC Article
  2. Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity. Lige B, et al. PLoS Pathog, 2011 Dec. PMID 22174676, Free PMC Article
  3. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. Krogh A, et al. J Mol Biol, 2001 Jan 19. PMID 11152613
  4. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by GeneDB

Process Evidence Code Pubs
acts_upstream_of_or_within lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Niemann-Pick type C1-related protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004325.2 Reference assembly

    Range
    304362..309257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350971.1 → XP_001351007.1  Niemann-Pick type C1-related protein [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351007.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8I266
    UniProtKB/TrEMBL
    A0A0L7K5L3, A0A2I0BXZ8
    Conserved Domains (1) summary
    cl25655
    Location:1066 → 1466
    Patched; Patched family
Nucleotide Protein
Heading Accession and Version

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Other Literature Sources
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Research Materials