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PF3D7_0515300 phosphatidylinositol 3-kinase [ Plasmodium falciparum 3D7 ]

Gene ID: 812967, updated on 12-Sep-2024

Summary

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Gene symbol
PF3D7_0515300
Gene description
phosphatidylinositol 3-kinase
Locus tag
PF3D7_0515300
See related
PlasmoDB:PF3D7_0515300; VEuPathDB:PF3D7_0515300
Gene type
protein coding
RNA name
phosphatidylinositol 3-kinase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_0515300 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_004326.2 (628981..635382)

Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene rhomboid protease ROM9 Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene amino acid transporter, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004326.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking. Vaid A, et al. Blood, 2010 Mar 25. PMID 20093402, Free PMC Article
  2. Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4-Kinase IIIβ. Sternberg AR, et al. Biochemistry, 2020 Jul 14. PMID 32543181
  3. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Mbengue A, et al. Nature, 2015 Apr 30. PMID 25874676, Free PMC Article
  4. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PfPI3K is involved in endocytosis from the host and trafficking of hemoglobin in the parasite
    Title: PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hemoglobin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in food vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in host intracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase
XP_001351710.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004326.2 Reference assembly

    Range
    628981..635382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351674.1 → XP_001351710.1  phosphatidylinositol 3-kinase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351710.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0L7LZ28, A0A8S9VLA9, Q8I3V5
    Conserved Domains (3) summary
    COG5032
    Location:1430 → 2123
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00896
    Location:1873 → 2130
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase
    cl00271
    Location:1097 → 1253
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
Nucleotide Protein
Heading Accession and Version

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