U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PF3D7_0515300 phosphatidylinositol 3-kinase [ Plasmodium falciparum 3D7 ]

Gene ID: 812967, updated on 8-Jul-2026
Gene symbol
PF3D7_0515300
Gene description
phosphatidylinositol 3-kinase
Locus tag
PF3D7_0515300
See related
PlasmoDB:PF3D7_0515300; VEuPathDB:PF3D7_0515300
Gene type
protein coding
RNA name
phosphatidylinositol 3-kinase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PF3D7_0515300 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_004326.2 (628981..635382)

Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene rhomboid protease ROM9 Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene amino acid transporter, putative

Genomic Sequence:
NC_004326.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking. Vaid A, et al. Blood, 2010 Mar 25. PMID 20093402, Free PMC Article
  2. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Mbengue A, et al. Nature, 2015 Apr 30. PMID 25874676, Free PMC Article
  3. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PfPI3K is involved in endocytosis from the host and trafficking of hemoglobin in the parasite
    Title: PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hemoglobin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pexophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in food vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in host intracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
phosphatidylinositol 3-kinase
XP_001351710.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004326.2 Reference assembly

    Range
    628981..635382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351674.1 → XP_001351710.1  phosphatidylinositol 3-kinase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351710.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q8I3V5
    Conserved Domains (3) summary
    COG5032
    Location:1430 → 2123
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00896
    Location:1873 → 2130
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase
    cl00271
    Location:1097 → 1253
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.