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GPR68 G protein-coupled receptor 68 [ Homo sapiens (human) ]

Gene ID: 8111, updated on 12-Oct-2019

Summary

Official Symbol
GPR68provided by HGNC
Official Full Name
G protein-coupled receptor 68provided by HGNC
Primary source
HGNC:HGNC:4519
See related
Ensembl:ENSG00000119714 MIM:601404
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OGR1; AI2A6; GPR12A
Summary
The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]
Expression
Broad expression in appendix (RPKM 1.7), skin (RPKM 1.5) and 22 other tissues See more
Orthologs

Genomic context

See GPR68 in Genome Data Viewer
Location:
14q32.11
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (91232532..91264581, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (91698876..91730898, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene D-glutamate cyclase Neighboring gene RNA, U7 small nuclear 30 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 11B Neighboring gene Sharpr-MPRA regulatory region 4292 Neighboring gene coiled-coil domain containing 88C Neighboring gene uncharacterized LOC107984673

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Osteoclast Signaling, organism-specific biosystem (from WikiPathways)
    Osteoclast Signaling, organism-specific biosystem
    Osteoclast Signaling
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

General gene information

Markers

Homology

Clone Names

  • MGC111379, MGC156983

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of monocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoclast development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ovarian cancer G-protein coupled receptor 1
Names
ovarian cancer G protein-coupled receptor, 1
sphingosylphosphorylcholine receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052988.1 RefSeqGene

    Range
    5001..26349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177676.2NP_001171147.1  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_001171147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-3 all encode the same protein. There is an upstream in-frame AUG (uAUG) present; however, translation is thought to begin from the annotated downstream AUG due to inhibition of the uAUG by a small overlapping open reading frame.
    Source sequence(s)
    AL135818, BC098567, BC128536
    Consensus CDS
    CCDS9894.2
    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A1A5B2
    Related
    ENSP00000498702.1, ENST00000650645.1
    Conserved Domains (1) summary
    cd15367
    Location:22297
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001348437.1NP_001335366.1  ovarian cancer G-protein coupled receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents th longest transcript. Variants 1-3 all encode the same protein. There is an upstream in-frame AUG (uAUG) present; however, translation is thought to begin from the annotated downstream AUG due to inhibition of the uAUG by a small overlapping open reading frame.
    Source sequence(s)
    AL135818
    Consensus CDS
    CCDS9894.2
    UniProtKB/Swiss-Prot
    Q15743
    Conserved Domains (1) summary
    cd15367
    Location:22297
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_003485.3NP_003476.3  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_003476.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-3 all encode the same protein. There is an upstream in-frame AUG (uAUG) present; however, translation is thought to begin from the annotated downstream AUG due to inhibition of the uAUG by a small overlapping open reading frame.
    Source sequence(s)
    BC098567, BM723705
    Consensus CDS
    CCDS9894.2
    UniProtKB/Swiss-Prot
    Q15743
    Related
    ENSP00000434045.2, ENST00000531499.2
    Conserved Domains (1) summary
    cd15367
    Location:22297
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    91232532..91264581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268112.3XP_005268169.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_005268169.1

    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A0A024R6D5
    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_005268111.3XP_005268168.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_005268168.1

    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A0A024R6D5
    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_005268110.4XP_005268167.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_005268167.1

    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A0A024R6D5
    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011537196.2XP_011535498.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011535498.1

    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A0A024R6D5
    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_011537197.3XP_011535499.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011535499.1

    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A0A024R6D5
    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_011537198.2XP_011535500.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011535500.1

    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A0A024R6D5
    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. XM_006720262.3XP_006720325.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006720325.1

    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A0A024R6D5
    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. XM_011537199.2XP_011535501.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011535501.1

    UniProtKB/Swiss-Prot
    Q15743
    UniProtKB/TrEMBL
    A0A024R6D5
    Conserved Domains (1) summary
    cd15367
    Location:32307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
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