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DPF3 double PHD fingers 3 [ Homo sapiens (human) ]

Gene ID: 8110, updated on 19-Sep-2021

Summary

Official Symbol
DPF3provided by HGNC
Official Full Name
double PHD fingers 3provided by HGNC
Primary source
HGNC:HGNC:17427
See related
Ensembl:ENSG00000205683 MIM:601672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CERD4; BAF45C; SMARCG3
Summary
This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Expression
Biased expression in ovary (RPKM 2.9), heart (RPKM 2.2) and 11 other tissues See more
Orthologs
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Genomic context

See DPF3 in Genome Data Viewer
Location:
14q24.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (72609034..72894101, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73075742..73360809, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 6 Neighboring gene uncharacterized LOC105370559 Neighboring gene microRNA 7843 Neighboring gene Sharpr-MPRA regulatory region 237 Neighboring gene uncharacterized LOC107984711 Neighboring gene ribosomal protein L36 pseudogene 3 Neighboring gene DDB1 and CUL4 associated factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14079

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nBAF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein DPF3
Names
BRG1-associated factor 45C
D4, zinc and double PHD fingers, family 3
zinc finger protein cer-d4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001280542.3NP_001267471.1  zinc finger protein DPF3 isoform 2

    See identical proteins and their annotated locations for NP_001267471.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' CDS and the 3' UTR compared to variant 1. The encoded isoform (2, also known as DPF3b) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC004828, AC006360, AC007160, AL392024
    Consensus CDS
    CCDS61497.1
    UniProtKB/Swiss-Prot
    Q92784
    Related
    ENSP00000450518.1, ENST00000556509.6
    Conserved Domains (4) summary
    COG5189
    Location:195222
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15530
    Location:318363
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15692
    Location:261317
    PHD1_DPF3; PHD finger 1 found in D4, zinc and double PHD fingers family 3 (DPF3)
    pfam14051
    Location:1379
    Requiem_N; N-terminal domain of DPF2/REQ
  2. NM_001280543.2NP_001267472.1  zinc finger protein DPF3 isoform 3

    See identical proteins and their annotated locations for NP_001267472.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC004828, AK123045, AK126074, AK294425, BC026305, DB172058
    Consensus CDS
    CCDS61495.1
    UniProtKB/Swiss-Prot
    Q92784
    Related
    ENSP00000481992.1, ENST00000614862.5
    Conserved Domains (2) summary
    pfam14051
    Location:2394
    Requiem_N; N-terminal domain of DPF2/REQ
    cl22851
    Location:271302
    PHD_SF; PHD finger superfamily
  3. NM_001280544.2NP_001267473.1  zinc finger protein DPF3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC004828, AC007160, AK124946, AK126933, BC026305
    Consensus CDS
    CCDS61496.1
    UniProtKB/Swiss-Prot
    Q92784
    UniProtKB/TrEMBL
    F8W7T1
    Related
    ENSP00000381791.3, ENST00000366353.8
    Conserved Domains (2) summary
    pfam14051
    Location:68139
    Requiem_N; N-terminal domain of DPF2/REQ
    cl22851
    Location:316347
    PHD_SF; PHD finger superfamily
  4. NM_012074.5NP_036206.3  zinc finger protein DPF3 isoform 1

    See identical proteins and their annotated locations for NP_036206.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (1, also known as DPF3a).
    Source sequence(s)
    AC004828, AK126933, BC026305, BC060801
    Consensus CDS
    CCDS45133.1
    UniProtKB/Swiss-Prot
    Q92784
    Related
    ENSP00000370614.4, ENST00000381216.8
    Conserved Domains (3) summary
    COG5189
    Location:195222
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    pfam14051
    Location:1379
    Requiem_N; N-terminal domain of DPF2/REQ
    cl22851
    Location:261292
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    72609034..72894101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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