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PF3D7_1129000 spermidine synthase [ Plasmodium falciparum 3D7 ]

Gene ID: 810848, updated on 12-Sep-2024
Gene symbol
PF3D7_1129000
Gene description
spermidine synthase
Locus tag
PF3D7_1129000
See related
PlasmoDB:PF3D7_1129000; VEuPathDB:PF3D7_1129000
Gene type
protein coding
RNA name
spermidine synthase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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See PF3D7_1129000 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
4
Sequence:
Chromosome: 11; NC_037282.1 (1121930..1123377)

Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene GPI-anchor transamidase, putative Neighboring gene conserved protein, unknown function Neighboring gene parasitophorous vacuolar protein 1 Neighboring gene 26S proteasome regulatory subunit RPN7, putative

Genomic Sequence:
NC_037282.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design. Sprenger J, et al. Acta Crystallogr D Biol Crystallogr, 2015 Mar. PMID 25760598, Free PMC Article
  2. Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. Dufe VT, et al. J Mol Biol, 2007 Oct 12. PMID 17822713
  3. Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase. Burger PB, et al. Bioorg Med Chem, 2007 Feb 15. PMID 17196392
  4. The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme. Haider N, et al. Mol Biochem Parasitol, 2005 Aug. PMID 15913804
  5. Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite. Sinha A, et al. mBio, 2021 Apr 27. PMID 33906926, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The complexes with the aniline compounds and BIPA revealed a new mode of ligand binding to PfSpdS.
    Title: Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design.
  2. Results show that binding of dcAdoMet to pfSPDS stabilizes the flexible gatekeeper loop of spermidine synthase and affects the conformation of the active-site amino acid residues, preparing the protein for binding of the second substrate.
    Title: Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.
  3. characterization of the structural and mechanistic properties of the PfSpdSyn as well as the elucidation of the active site residues involved in substrate, product, and inhibitor interactions
    Title: Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables spermidine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within spermidine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
Preferred Names
spermidine synthase
XP_001347972.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037282.1 Reference assembly

    Range
    1121930..1123377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001347936.1 → XP_001347972.1  spermidine synthase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001347972.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024W5H9, A0A0L7KB04, Q8II73, Q9NFS5, W7EZT8, W7JTL4
    Conserved Domains (1) summary
    cl17173
    Location:43 → 319
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2PSS_A.1
2PSS_B.1
2PSS_C.1
2PT6_A.1
2PT6_B.1
2PT6_C.1
2PT9_A.1
2PT9_B.1
2PT9_C.1
6I1N_A.1
6I1N_B.1
6I1N_C.1

Gene LinkOut

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Molecular Biology Databases
Research Materials
Miscellaneous