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PF3D7_1012600 GMP synthase [glutamine-hydrolyzing] [ Plasmodium falciparum 3D7 ]

Gene ID: 810281, updated on 12-Sep-2024
Gene symbol
PF3D7_1012600
Gene description
GMP synthase [glutamine-hydrolyzing]
Locus tag
PF3D7_1012600
See related
PlasmoDB:PF3D7_1012600; VEuPathDB:PF3D7_1012600
Gene type
protein coding
RNA name
GMP synthase [glutamine-hydrolyzing]
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PF3D7_1012600 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
1
Sequence:
Chromosome: 10; NC_037281.1 (482527..484194, complement)

Chromosome 10 - NC_037281.1Genomic Context describing neighboring genes Neighboring gene hypoxanthine-guanine phosphoribosyltransferase Neighboring gene phosphoglucomutase, putative Neighboring gene NLI interacting factor-like phosphatase, putative Neighboring gene conserved Plasmodium protein, unknown function

Genomic Sequence:
NC_037281.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation. Ballut L, et al. Nat Commun, 2015 Nov 23. PMID 26592566, Free PMC Article
  2. Kinetic and biochemical characterization of Plasmodium falciparum GMP synthetase. Bhat JY, et al. Biochem J, 2008 Jan 1. PMID 17868038
  3. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conformational changes in helix 371-375 of GMP synthetase holding catalytic residues and in loop 376-401 along the rotation trajectory trigger the different steps of catalysis
    Title: Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation.
  2. biochemical characterization of Plasmodium falciparum GMP synthetase
    Title: Kinetic and biochemical characterization of Plasmodium falciparum GMP synthetase.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables GMP synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within purine nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
GMP synthase [glutamine-hydrolyzing]
XP_001347408.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037281.1 Reference assembly

    Range
    482527..484194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001347372.1 → XP_001347408.1  GMP synthase [glutamine-hydrolyzing] [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001347408.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8IJR9, Q9U775
    UniProtKB/TrEMBL
    A0A024V650, A0A024VQX8, A0A024W6E9, A0A024WQ52, A0A024X752, A0A0L0CX40, A0A0L1IFH6, A0A0L7KGS6, A0A0L7M8F2, W4IG59, W4J3D0, W7FC96, W7FID6, W7JN10, W7K581
    Conserved Domains (1) summary
    PRK00074
    Location:7 → 555
    guaA; GMP synthase; Reviewed
Nucleotide Protein
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