Format

Send to:

Choose Destination

GJA9 gap junction protein alpha 9 [ Homo sapiens (human) ]

Gene ID: 81025, updated on 23-Nov-2021

Summary

Official Symbol
GJA9provided by HGNC
Official Full Name
gap junction protein alpha 9provided by HGNC
Primary source
HGNC:HGNC:19155
See related
Ensembl:ENSG00000131233 MIM:611923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CX58; CX59; GJA10
Summary
Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 4.0), skin (RPKM 0.6) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GJA9 in Genome Data Viewer
Location:
1p34.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (38874069..38881587, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (39339741..39347259, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Ras related GTP binding C Neighboring gene Sharpr-MPRA regulatory region 3933 Neighboring gene GJA9-MYCBP readthrough Neighboring gene MYC binding protein Neighboring gene uncharacterized LOC105378663 Neighboring gene rhomboid like 2 Neighboring gene uncharacterized LOC105378662 Neighboring gene RNA, U6 small nuclear 605, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough GJA9-MYCBP

Readthrough gene: GJA9-MYCBP, Included gene: MYCBP

Potential readthrough

Included gene: RHBDL2

Homology

Clone Names

  • MGC50985

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gap junction alpha-9 protein
Names
connexin 59
connexin-58
gap junction alpha 10
gap junction protein, alpha 9, 59kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030772.5NP_110399.2  gap junction alpha-9 protein precursor

    See identical proteins and their annotated locations for NP_110399.2

    Status: VALIDATED

    Source sequence(s)
    AF271261, AK312811, AL139260, BU689816
    Consensus CDS
    CCDS432.1
    UniProtKB/Swiss-Prot
    P57773
    Related
    ENSP00000350415.3, ENST00000357771.5
    Conserved Domains (1) summary
    pfam00029
    Location:3235
    Connexin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    38874069..38881587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center