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Defb5 defensin beta 5 [ Mus musculus (house mouse) ]

Gene ID: 81007, updated on 26-Sep-2022

Summary

Official Symbol
Defb5provided by MGI
Official Full Name
defensin beta 5provided by MGI
Primary source
MGI:MGI:1933153
See related
Ensembl:ENSMUSG00000039785 AllianceGenome:MGI:1933153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BD-5
Summary
Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human DEFB4B (defensin beta 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

See Defb5 in Genome Data Viewer
Location:
8; 8 A1.3
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (19297608..19300844)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (19247592..19250828)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin beta 6 Neighboring gene defensin beta 46 Neighboring gene defensin beta 3 Neighboring gene defensin, alpha, pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR6 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CCR6 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030734.3NP_109659.2  beta-defensin 5 precursor

    See identical proteins and their annotated locations for NP_109659.2

    Status: VALIDATED

    Source sequence(s)
    AC163997
    Consensus CDS
    CCDS40257.1
    UniProtKB/Swiss-Prot
    F8VQA5, Q9EPV9
    Related
    ENSMUSP00000106391.2, ENSMUST00000110763.2
    Conserved Domains (1) summary
    pfam00711
    Location:2962
    Defensin_beta; Beta defensin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    19297608..19300844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)