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Slc26a5 solute carrier family 26, member 5 [ Mus musculus (house mouse) ]

Gene ID: 80979, updated on 23-May-2018
Official Symbol
Slc26a5provided by MGI
Official Full Name
solute carrier family 26, member 5provided by MGI
Primary source
MGI:MGI:1933154
See related
Ensembl:ENSMUSG00000029015 Vega:OTTMUSG00000023668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pres; prestin
Expression
Low expression observed in reference dataset See more
Orthologs
See Slc26a5 in Genome Data Viewer
Location:
5 A3; 5 9.97 cM
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (21809001..21865604, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (21316473..21371422, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene reelin Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Clone Names

  • MGC124328, MGC124329

Gene Ontology Provided by MGI

Function Evidence Code Pubs
anion:anion antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
anion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
fructose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
oxalate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
prestin
Names
outer hair cell motor protein
prestin (motor protein)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289787.1NP_001276716.1  prestin isoform 2

    See identical proteins and their annotated locations for NP_001276716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC113028, AC125313, AY024359, CJ076475
    Consensus CDS
    CCDS71547.1
    UniProtKB/Swiss-Prot
    Q99NH7
    UniProtKB/TrEMBL
    Q32MT6
    Related
    ENSMUSP00000110830.1, OTTMUSP00000027909, ENSMUST00000115176.7, OTTMUST00000057764
    Conserved Domains (3) summary
    cd07042
    Location:489657
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    cd07043
    Location:552646
    STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
    TIGR00815
    Location:66672
    sulP; high affinity sulphate transporter 1
  2. NM_001289788.1NP_001276717.1  prestin isoform 3

    See identical proteins and their annotated locations for NP_001276717.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC113028, AC125313, AY024359, CJ076475
    UniProtKB/Swiss-Prot
    Q99NH7
    UniProtKB/TrEMBL
    Q32MT7
    Conserved Domains (3) summary
    cd07042
    Location:260428
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    cd07043
    Location:323417
    STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
    TIGR00815
    Location:5443
    sulP; high affinity sulphate transporter 1
  3. NM_030727.5NP_109652.3  prestin isoform 1

    See identical proteins and their annotated locations for NP_109652.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC113028, AC125313, AY024359, CJ076475
    Consensus CDS
    CCDS19109.1
    UniProtKB/Swiss-Prot
    Q99NH7
    Related
    ENSMUSP00000030878.1, OTTMUSP00000027908, ENSMUST00000030878.7, OTTMUST00000057763
    Conserved Domains (3) summary
    cd07042
    Location:526694
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    cd07043
    Location:589683
    STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
    TIGR00815
    Location:66709
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    21809001..21865604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535818.1XP_006535881.1  prestin isoform X1

    Conserved Domains (3) summary
    cd07042
    Location:464632
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    cd07043
    Location:527621
    STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
    TIGR00815
    Location:4647
    sulP; high affinity sulphate transporter 1
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