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Slc26a5 solute carrier family 26, member 5 [ Mus musculus (house mouse) ]

Gene ID: 80979, updated on 18-Jul-2024

Summary

Official Symbol
Slc26a5provided by MGI
Official Full Name
solute carrier family 26, member 5provided by MGI
Primary source
MGI:MGI:1933154
See related
Ensembl:ENSMUSG00000029015 AllianceGenome:MGI:1933154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pres; prestin
Summary
Enables spectrin binding activity. Acts upstream of or within regulation of membrane potential. Located in basolateral plasma membrane; lateral plasma membrane; and lateral wall of outer hair cell. Is expressed in brain; cochlea; embryo; and organ of Corti. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61. Orthologous to human SLC26A5 (solute carrier family 26 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Slc26a5 in Genome Data Viewer
Location:
5 A3; 5 9.97 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (22013999..22070602, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21809001..21865604, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2 Neighboring gene STARR-seq mESC enhancer starr_12580 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12582 Neighboring gene reelin Neighboring gene predicted gene 10475 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC124328, MGC124329

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic anion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in oxalate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
involved_in sulfate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lateral wall of outer hair cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prestin
Names
outer hair cell motor protein
prestin (motor protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289787.1NP_001276716.1  prestin isoform 2

    See identical proteins and their annotated locations for NP_001276716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC113028, AC125313, AY024359, CJ076475
    Consensus CDS
    CCDS71547.1
    UniProtKB/TrEMBL
    D3Z013, Q32MT6
    Related
    ENSMUSP00000110830.2, ENSMUST00000115176.8
    Conserved Domains (3) summary
    cd07042
    Location:489657
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    cd07043
    Location:552646
    STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
    TIGR00815
    Location:66672
    sulP; high affinity sulphate transporter 1
  2. NM_001289788.1NP_001276717.1  prestin isoform 3

    See identical proteins and their annotated locations for NP_001276717.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC113028, AC125313, AY024359, CJ076475
    UniProtKB/TrEMBL
    Q32MT7
    Conserved Domains (3) summary
    cd07042
    Location:260428
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    cd07043
    Location:323417
    STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
    TIGR00815
    Location:5443
    sulP; high affinity sulphate transporter 1
  3. NM_030727.5NP_109652.3  prestin isoform 1

    See identical proteins and their annotated locations for NP_109652.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC113028, AC125313, AY024359, CJ076475
    Consensus CDS
    CCDS19109.1
    UniProtKB/Swiss-Prot
    Q80ZB1, Q99NH7
    UniProtKB/TrEMBL
    D3Z013
    Related
    ENSMUSP00000030878.2, ENSMUST00000030878.8
    Conserved Domains (3) summary
    cd07042
    Location:526694
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    cd07043
    Location:589683
    STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
    TIGR00815
    Location:66709
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    22013999..22070602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535818.1XP_006535881.1  prestin isoform X1

    UniProtKB/TrEMBL
    D3Z013
    Conserved Domains (2) summary
    cd07043
    Location:527621
    STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
    TIGR00815
    Location:4647
    sulP; high affinity sulphate transporter 1