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Pum1 pumilio RNA-binding family member 1 [ Mus musculus (house mouse) ]

Gene ID: 80912, updated on 12-May-2024

Summary

Official Symbol
Pum1provided by MGI
Official Full Name
pumilio RNA-binding family member 1provided by MGI
Primary source
MGI:MGI:1931749
See related
Ensembl:ENSMUSG00000028580 AllianceGenome:MGI:1931749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pumm; mKIAA0099
Summary
Enables mRNA 3'-UTR binding activity. Involved in several processes, including adult locomotory behavior; posttranscriptional regulation of gene expression; and spermatogenesis. Acts upstream of or within posttranscriptional regulation of gene expression. Located in cytoplasm. Is expressed in several structures, including central nervous system; intestine; olfactory epithelium; retina; and testis. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Orthologous to human PUM1 (pumilio RNA binding family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 32.2), whole brain E14.5 (RPKM 27.8) and 28 other tissues See more
Orthologs
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Genomic context

See Pum1 in Genome Data Viewer
Location:
4 D2.2; 4 63.43 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130390509..130508875)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130663238..130781564)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Na+/K+ transporting ATPase interacting 1 Neighboring gene STARR-seq mESC enhancer starr_11526 Neighboring gene STARR-seq mESC enhancer starr_11530 Neighboring gene predicted gene, 53228 Neighboring gene STARR-seq mESC enhancer starr_11531 Neighboring gene STARR-seq mESC enhancer starr_11533 Neighboring gene small nucleolar RNA, C/D box 85 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:130330830-130331017 Neighboring gene predicted gene, 24091 Neighboring gene STARR-positive B cell enhancer ABC_E6227 Neighboring gene predicted gene, 23711 Neighboring gene predicted gene 12972 Neighboring gene syndecan 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (3) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pumilio homolog 1
Names
pumilio 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159603.2NP_001153075.1  pumilio homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001153075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses multiple alternate in-frame splice sites, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK162742, BE653001, BU708930, BY782432, CB724122, CF157665, CF746520, CJ064695, CJ227969, CN530452, CN530471, CN538180, CN724656, CV559585
    Consensus CDS
    CCDS51311.1
    UniProtKB/TrEMBL
    Q3UR00
    Related
    ENSMUSP00000095476.3, ENSMUST00000097864.9
    Conserved Domains (1) summary
    cd07920
    Location:8431164
    Pumilio; Pumilio-family RNA binding domain
  2. NM_001159604.2NP_001153076.1  pumilio homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001153076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1, which results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK161135, AK162742, BC048174, BY782432, CF746520, CJ227969
    Consensus CDS
    CCDS51312.1
    UniProtKB/TrEMBL
    Q3TQ21, Q3UR00
    Related
    ENSMUSP00000095474.3, ENSMUST00000097862.3
    Conserved Domains (1) summary
    cd07920
    Location:8431166
    Pumilio; Pumilio-family RNA binding domain
  3. NM_001159605.2NP_001153077.1  pumilio homolog 1 isoform 4

    See identical proteins and their annotated locations for NP_001153077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple coding region differences, compared to variant 1, which results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AK161135, AK162742, BY782432, CF746520, CJ227969
    Consensus CDS
    CCDS51313.1
    UniProtKB/TrEMBL
    Q3TTW5, Q3UR00
    Related
    ENSMUSP00000101613.3, ENSMUST00000105992.9
    Conserved Domains (1) summary
    cd07920
    Location:7471070
    Pumilio; Pumilio-family RNA binding domain
  4. NM_001159606.2NP_001153078.1  pumilio homolog 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple coding region differences, compared to variant 1, which results in a shorter protein (isoform 5), compared to isoform 1.
    Source sequence(s)
    AK147185, AK161135, AK162742, BY782432, CF746520, CJ227969, CN526490
    Consensus CDS
    CCDS51314.1
    UniProtKB/TrEMBL
    E9Q6M7, Q3UHW0
    Related
    ENSMUSP00000101612.3, ENSMUST00000105991.9
    Conserved Domains (1) summary
    cd07920
    Location:601922
    Pumilio; Pumilio-family RNA binding domain
  5. NM_001356564.1NP_001343493.1  pumilio homolog 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AK162742, AL627104, CF746520, CJ227969
    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7651086
    Pumilio; Pumilio-family RNA binding domain
  6. NM_001356565.1NP_001343494.1  pumilio homolog 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AK162742, AL627104, BY782432, CF746520, CJ227969, CN456820, CN724656, CV559585
    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:7471068
    Pumilio; Pumilio-family RNA binding domain
  7. NM_001356566.1NP_001343495.1  pumilio homolog 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AK162742, AL627104, BE653001, BY782432, CF746520, CJ093090, CJ227969, CN724656, CV559585
    UniProtKB/TrEMBL
    Q3UHW0
    Conserved Domains (1) summary
    cd07920
    Location:601924
    Pumilio; Pumilio-family RNA binding domain
  8. NM_030722.3NP_109647.2  pumilio homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_109647.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK162742, BE653001, BU708930, BY782432, CB724122, CF746520, CJ064695, CJ227969, CN530452, CN530471, CN538180, CN724656
    Consensus CDS
    CCDS18710.1
    UniProtKB/Swiss-Prot
    Q80U78, Q80X96, Q80YU8, Q8BPV7, Q9EPU6
    UniProtKB/TrEMBL
    Q3UR00
    Related
    ENSMUSP00000030315.7, ENSMUST00000030315.13
    Conserved Domains (1) summary
    cd07920
    Location:8441167
    Pumilio; Pumilio-family RNA binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    130390509..130508875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539291.5XP_006539354.1  pumilio homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006539354.1

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8481171
    Pumilio; Pumilio-family RNA binding domain
  2. XM_006539294.5XP_006539357.1  pumilio homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_006539357.1

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8481169
    Pumilio; Pumilio-family RNA binding domain
  3. XM_006539296.5XP_006539359.1  pumilio homolog 1 isoform X10

    See identical proteins and their annotated locations for XP_006539359.1

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7691092
    Pumilio; Pumilio-family RNA binding domain
  4. XM_006539297.5XP_006539360.1  pumilio homolog 1 isoform X11

    See identical proteins and their annotated locations for XP_006539360.1

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7691090
    Pumilio; Pumilio-family RNA binding domain
  5. XM_017320459.3XP_017175948.1  pumilio homolog 1 isoform X6

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8441165
    Pumilio; Pumilio-family RNA binding domain
  6. XM_006539295.5XP_006539358.1  pumilio homolog 1 isoform X8

    See identical proteins and their annotated locations for XP_006539358.1

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8091132
    Pumilio; Pumilio-family RNA binding domain
  7. XM_030253924.2XP_030109784.1  pumilio homolog 1 isoform X9

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8091130
    Pumilio; Pumilio-family RNA binding domain
  8. XM_036164565.1XP_036020458.1  pumilio homolog 1 isoform X21

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7301053
    Pumilio; Pumilio-family RNA binding domain
  9. XM_030253933.2XP_030109793.1  pumilio homolog 1 isoform X32

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7301051
    Pumilio; Pumilio-family RNA binding domain
  10. XM_006539303.5XP_006539366.1  pumilio homolog 1 isoform X31

    See identical proteins and their annotated locations for XP_006539366.1

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:659982
    Pumilio; Pumilio-family RNA binding domain
  11. XM_006539293.5XP_006539356.1  pumilio homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006539356.1

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8471170
    Pumilio; Pumilio-family RNA binding domain
  12. XM_030253922.2XP_030109782.1  pumilio homolog 1 isoform X5

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8431166
    Pumilio; Pumilio-family RNA binding domain
  13. XM_036164562.1XP_036020455.1  pumilio homolog 1 isoform X15

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8431164
    Pumilio; Pumilio-family RNA binding domain
  14. XM_030253923.2XP_030109783.1  pumilio homolog 1 isoform X7

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8421165
    Pumilio; Pumilio-family RNA binding domain
  15. XM_036164564.1XP_036020457.1  pumilio homolog 1 isoform X17

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8421163
    Pumilio; Pumilio-family RNA binding domain
  16. XM_006539299.5XP_006539362.1  pumilio homolog 1 isoform X18

    See identical proteins and their annotated locations for XP_006539362.1

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:7521075
    Pumilio; Pumilio-family RNA binding domain
  17. XM_030253931.2XP_030109791.1  pumilio homolog 1 isoform X28

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:7521073
    Pumilio; Pumilio-family RNA binding domain
  18. XM_030253925.2XP_030109785.1  pumilio homolog 1 isoform X19

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:7481071
    Pumilio; Pumilio-family RNA binding domain
  19. XM_030253926.2XP_030109786.1  pumilio homolog 1 isoform X20

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:7481069
    Pumilio; Pumilio-family RNA binding domain
  20. XM_036164568.1XP_036020461.1  pumilio homolog 1 isoform X29

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:669992
    Pumilio; Pumilio-family RNA binding domain
  21. XM_036164569.1XP_036020462.1  pumilio homolog 1 isoform X30

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:668989
    Pumilio; Pumilio-family RNA binding domain
  22. XM_030253928.2XP_030109788.1  pumilio homolog 1 isoform X26

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:7131036
    Pumilio; Pumilio-family RNA binding domain
  23. XM_006539308.4XP_006539371.1  pumilio homolog 1 isoform X36

    See identical proteins and their annotated locations for XP_006539371.1

    UniProtKB/TrEMBL
    Q3UHW0
    Conserved Domains (1) summary
    cd07920
    Location:606929
    Pumilio; Pumilio-family RNA binding domain
  24. XM_036164573.1XP_036020466.1  pumilio homolog 1 isoform X37

    UniProtKB/TrEMBL
    Q3UHW0
    Conserved Domains (1) summary
    cd07920
    Location:606927
    Pumilio; Pumilio-family RNA binding domain
  25. XM_006539309.4XP_006539372.1  pumilio homolog 1 isoform X38

    See identical proteins and their annotated locations for XP_006539372.1

    UniProtKB/TrEMBL
    Q3UHW0
    Conserved Domains (1) summary
    cd07920
    Location:602925
    Pumilio; Pumilio-family RNA binding domain
  26. XM_006539300.5XP_006539363.1  pumilio homolog 1 isoform X22

    See identical proteins and their annotated locations for XP_006539363.1

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:7281051
    Pumilio; Pumilio-family RNA binding domain
  27. XM_030253927.2XP_030109787.1  pumilio homolog 1 isoform X24

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:7241047
    Pumilio; Pumilio-family RNA binding domain
  28. XM_036164567.1XP_036020460.1  pumilio homolog 1 isoform X27

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:7241045
    Pumilio; Pumilio-family RNA binding domain
  29. XM_030253930.2XP_030109790.1  pumilio homolog 1 isoform X25

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:7231046
    Pumilio; Pumilio-family RNA binding domain
  30. XM_036164572.1XP_036020465.1  pumilio homolog 1 isoform X35

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:644967
    Pumilio; Pumilio-family RNA binding domain
  31. XM_006539301.5XP_006539364.1  pumilio homolog 1 isoform X23

    See identical proteins and their annotated locations for XP_006539364.1

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:7271050
    Pumilio; Pumilio-family RNA binding domain
  32. XM_036164571.1XP_036020464.1  pumilio homolog 1 isoform X34

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:627950
    Pumilio; Pumilio-family RNA binding domain
  33. XM_006539314.5XP_006539377.1  pumilio homolog 1 isoform X39

    See identical proteins and their annotated locations for XP_006539377.1

    UniProtKB/TrEMBL
    Q3UHW0
    Conserved Domains (1) summary
    cd07920
    Location:486809
    Pumilio; Pumilio-family RNA binding domain
  34. XM_036164574.1XP_036020467.1  pumilio homolog 1 isoform X40

    UniProtKB/TrEMBL
    Q3UHW0
    Conserved Domains (1) summary
    cd07920
    Location:481804
    Pumilio; Pumilio-family RNA binding domain
  35. XM_006539292.4XP_006539355.1  pumilio homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006539355.1

    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8481171
    Pumilio; Pumilio-family RNA binding domain
  36. XM_036164561.1XP_036020454.1  pumilio homolog 1 isoform X4

    UniProtKB/Swiss-Prot
    Q80U78, Q80X96, Q80YU8, Q8BPV7, Q9EPU6
    UniProtKB/TrEMBL
    Q3UR00
    Conserved Domains (1) summary
    cd07920
    Location:8441167
    Pumilio; Pumilio-family RNA binding domain
  37. XM_017320461.3XP_017175950.1  pumilio homolog 1 isoform X13

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7641087
    Pumilio; Pumilio-family RNA binding domain
  38. XM_017320463.2XP_017175952.1  pumilio homolog 1 isoform X16

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7641085
    Pumilio; Pumilio-family RNA binding domain
  39. XM_017320460.3XP_017175949.1  pumilio homolog 1 isoform X12

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7651088
    Pumilio; Pumilio-family RNA binding domain
  40. XM_017320462.3XP_017175951.1  pumilio homolog 1 isoform X14

    UniProtKB/TrEMBL
    Q3TRI4
    Conserved Domains (1) summary
    cd07920
    Location:7651086
    Pumilio; Pumilio-family RNA binding domain
  41. XM_036164566.1XP_036020459.1  pumilio homolog 1 isoform X24

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:7241047
    Pumilio; Pumilio-family RNA binding domain
  42. XM_036164570.1XP_036020463.1  pumilio homolog 1 isoform X33

    UniProtKB/TrEMBL
    Q3U4T5
    Conserved Domains (1) summary
    cd07920
    Location:632955
    Pumilio; Pumilio-family RNA binding domain