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Kcnip2 Kv channel-interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 80906, updated on 21-May-2024

Summary

Official Symbol
Kcnip2provided by MGI
Official Full Name
Kv channel-interacting protein 2provided by MGI
Primary source
MGI:MGI:2135916
See related
Ensembl:ENSMUSG00000025221 AllianceGenome:MGI:2135916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KChIP2
Summary
This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Expression
Biased expression in heart adult (RPKM 60.6), cortex adult (RPKM 30.5) and 5 other tissues See more
Orthologs
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Genomic context

See Kcnip2 in Genome Data Viewer
Location:
19 C3; 19 38.75 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45780785..45804948, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45792346..45816422, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11033 Neighboring gene nucleoplasmin 3 Neighboring gene O-GlcNAcase Neighboring gene STARR-positive B cell enhancer ABC_E4286 Neighboring gene STARR-seq mESC enhancer starr_46285 Neighboring gene STARR-seq mESC enhancer starr_46286 Neighboring gene armadillo-like helical domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E7665 Neighboring gene STARR-seq mESC enhancer starr_46288 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46291 Neighboring gene RIKEN cDNA 4930505N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E4287 Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to A-type (transient outward) potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in clustering of voltage-gated potassium channels ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart contraction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Kv4.2-KChIP2 channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Kv channel-interacting protein 2
Names
A-type potassium channel modulatory protein 2
potassium channel-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276358.1NP_001263287.1  Kv channel-interacting protein 2 isoform d

    See identical proteins and their annotated locations for NP_001263287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) uses an alternate 5' exon structure, lacks an in-frame segment in the coding region, and initiates translation at an alternate start codon, compared to variant a. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AY647241, BC056434
    Consensus CDS
    CCDS70955.1
    UniProtKB/TrEMBL
    Q3YAA4
    Related
    ENSMUSP00000084215.5, ENSMUST00000086993.11
    Conserved Domains (1) summary
    COG5126
    Location:48214
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_001424873.1NP_001411802.1  Kv channel-interacting protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC149086
    UniProtKB/TrEMBL
    A0A5F8MPB0
    Related
    ENSMUSP00000158890.2, ENSMUST00000239049.2
  3. NM_030716.3NP_109641.2  Kv channel-interacting protein 2 isoform b

    See identical proteins and their annotated locations for NP_109641.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) lacks an internal exon in the coding region but maintains the reading frame, compared to variant a. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    BC056434, CX122626, DQ148497
    Consensus CDS
    CCDS50453.1
    UniProtKB/TrEMBL
    E9QNK8, Q3YAB2
    Related
    ENSMUSP00000078400.4, ENSMUST00000079431.10
    Conserved Domains (1) summary
    COG5126
    Location:75241
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  4. NM_145703.2NP_663749.1  Kv channel-interacting protein 2 isoform a

    See identical proteins and their annotated locations for NP_663749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a, also known as KCHIP2L).
    Source sequence(s)
    BC056434, CX122626, DQ148496
    Consensus CDS
    CCDS38004.1
    UniProtKB/Swiss-Prot
    Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69
    UniProtKB/TrEMBL
    Q3YAB3
    Related
    ENSMUSP00000125142.3, ENSMUST00000162528.9
    Conserved Domains (1) summary
    COG5126
    Location:93259
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  5. NM_145704.2NP_663750.1  Kv channel-interacting protein 2 isoform c

    See identical proteins and their annotated locations for NP_663750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) lacks two consecutive internal exons in the coding region but maintains the reading frame, compared to variant a. The encoded isoform (c, also known as KCHIP2S) is shorter, compared to isoform a.
    Source sequence(s)
    BC056434, BC138496, CX122626
    Consensus CDS
    CCDS29868.1
    UniProtKB/TrEMBL
    E0CY54, E9QNK8, Q3YAB1
    Related
    ENSMUSP00000124482.3, ENSMUST00000161886.9
    Conserved Domains (1) summary
    COG5126
    Location:43209
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    45780785..45804948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527470.5XP_006527533.1  Kv channel-interacting protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69
    Conserved Domains (1) summary
    COG5126
    Location:109275
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. XM_017318315.3XP_017173804.1  Kv channel-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69
    UniProtKB/TrEMBL
    Q3YAB3
    Conserved Domains (1) summary
    COG5126
    Location:93259
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]