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ILKAP ILK associated serine/threonine phosphatase [ Homo sapiens (human) ]

Gene ID: 80895, updated on 4-Oct-2020

Summary

Official Symbol
ILKAPprovided by HGNC
Official Full Name
ILK associated serine/threonine phosphataseprovided by HGNC
Primary source
HGNC:HGNC:15566
See related
Ensembl:ENSG00000132323 MIM:618909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2CD; PPM1O; ILKAP2; ILKAP3; PP2C-DELTA
Summary
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 11.1), testis (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See ILKAP in Genome Data Viewer
Location:
2q37.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (238170401..238203702, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (239079043..239112343, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene kelch like family member 30 Neighboring gene erythroferrone Neighboring gene long intergenic non-protein coding RNA 2610 Neighboring gene TARDBP pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4846, FLJ10181, DKFZp434J2031

Gene Ontology Provided by GOA

Function Evidence Code Pubs
magnesium-dependent protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
integrin-linked kinase-associated serine/threonine phosphatase 2C
Names
integrin-linked kinase associated phosphatase
protein phosphatase 2c, delta isozyme
protein phosphatase, Mg2+/Mn2+ dependent 1O
NP_110395.1
XP_005246163.1
XP_006712847.1
XP_011510248.1
XP_016860545.1
XP_016860546.1
XP_016860547.1
XP_024308930.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030768.3NP_110395.1  integrin-linked kinase-associated serine/threonine phosphatase 2C

    See identical proteins and their annotated locations for NP_110395.1

    Status: REVIEWED

    Source sequence(s)
    AC016757
    Consensus CDS
    CCDS2526.1
    UniProtKB/Swiss-Prot
    Q9H0C8
    Related
    ENSP00000254654.3, ENST00000254654.8
    Conserved Domains (1) summary
    cd00143
    Location:108390
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    238170401..238203702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005057.1XP_016860546.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

    Related
    ENST00000463129.5
    Conserved Domains (1) summary
    cd00143
    Location:1270
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  2. XM_024453162.1XP_024308930.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

    Conserved Domains (1) summary
    cd00143
    Location:1270
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  3. XM_017005058.1XP_016860547.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X3

    Conserved Domains (1) summary
    cd00143
    Location:10258
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  4. XM_006712784.1XP_006712847.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1

    See identical proteins and their annotated locations for XP_006712847.1

    Conserved Domains (1) summary
    cd00143
    Location:40322
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  5. XM_011511946.2XP_011510248.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X3

    Conserved Domains (1) summary
    cd00143
    Location:10258
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  6. XM_005246106.1XP_005246163.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

    See identical proteins and their annotated locations for XP_005246163.1

    Conserved Domains (1) summary
    cd00143
    Location:1270
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  7. XM_017005056.2XP_016860545.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

    Conserved Domains (1) summary
    cd00143
    Location:1270
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RNA

  1. XR_923033.1 RNA Sequence

    Related
    ENST00000612675.4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176799.1: Suppressed sequence

    Description
    NM_176799.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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