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Tmprss5 transmembrane protease, serine 5 (spinesin) [ Mus musculus (house mouse) ]

Gene ID: 80893, updated on 23-May-2018

Summary

Official Symbol
Tmprss5provided by MGI
Official Full Name
transmembrane protease, serine 5 (spinesin)provided by MGI
Primary source
MGI:MGI:1933407
See related
Ensembl:ENSMUSG00000032268 Vega:OTTMUSG00000036070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
spinesin
Expression
Broad expression in colon adult (RPKM 2.0), stomach adult (RPKM 1.3) and 18 other tissues See more
Orthologs

Genomic context

See Tmprss5 in Genome Data Viewer
Location:
9; 9 A5.3
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (49080719..49117591)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (48910884..48925692)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene claudin 25, pseudogene Neighboring gene zw10 kinetochore protein Neighboring gene predicted gene 4894 Neighboring gene dopamine receptor D2 Neighboring gene predicted gene, 46112

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transmembrane protease serine 5
NP_109634.2
XP_006510770.1
XP_006510771.1
XP_006510772.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359460.1NP_001346389.1  transmembrane protease serine 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159825, AC160137
    Conserved Domains (2) summary
    smart00020
    Location:217448
    Tryp_SPc; Trypsin-like serine protease
    pfam15494
    Location:116213
    SRCR_2; Scavenger receptor cysteine-rich domain
  2. NM_030709.2NP_109634.2  transmembrane protease serine 5 isoform 2

    See identical proteins and their annotated locations for NP_109634.2

    Status: VALIDATED

    Source sequence(s)
    AB016230, AB041037, AC159825, BC132151
    Consensus CDS
    CCDS52789.1
    UniProtKB/Swiss-Prot
    Q9ER04
    UniProtKB/TrEMBL
    A2RSL0
    Related
    ENSMUSP00000064527.5, OTTMUSP00000051271, ENSMUST00000070390.11, OTTMUST00000092668
    Conserved Domains (3) summary
    smart00020
    Location:207438
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:208441
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:106203
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    49080719..49117591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510708.3XP_006510771.1  transmembrane protease serine 5 isoform X2

    See identical proteins and their annotated locations for XP_006510771.1

    UniProtKB/TrEMBL
    A2RSL0
    Conserved Domains (3) summary
    smart00020
    Location:207438
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:208441
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:106203
    SRCR_2; Scavenger receptor cysteine-rich domain
  2. XM_006510707.3XP_006510770.1  transmembrane protease serine 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9ER04
    Related
    ENSMUSP00000132181.1, OTTMUSP00000051269, ENSMUST00000165088.7, OTTMUST00000092665
    Conserved Domains (2) summary
    smart00020
    Location:217448
    Tryp_SPc; Trypsin-like serine protease
    pfam15494
    Location:116213
    SRCR_2; Scavenger receptor cysteine-rich domain
  3. XM_006510709.2XP_006510772.1  transmembrane protease serine 5 isoform X3

    Related
    ENSMUSP00000131650.1, OTTMUSP00000051272, ENSMUST00000167095.7, OTTMUST00000092669
    Conserved Domains (3) summary
    smart00020
    Location:184415
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:185418
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:83180
    SRCR_2; Scavenger receptor cysteine-rich domain

RNA

  1. XR_001779076.1 RNA Sequence

    Related
    ENSMUST00000166272.7, OTTMUST00000092667
  2. XR_001779075.1 RNA Sequence

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