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YEATS4 YEATS domain containing 4 [ Homo sapiens (human) ]

Gene ID: 8089, updated on 9-Feb-2020

Summary

Official Symbol
YEATS4provided by HGNC
Official Full Name
YEATS domain containing 4provided by HGNC
Primary source
HGNC:HGNC:24859
See related
Ensembl:ENSG00000127337 MIM:602116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
Summary
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Expression
Broad expression in testis (RPKM 7.3), bone marrow (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See YEATS4 in Genome Data Viewer
Location:
12q15
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (69359705..69427077)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69753490..69784576)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene C1GALT1 pseudogene 1 Neighboring gene lysozyme Neighboring gene RNA, 7SL, cytoplasmic 804, pseudogene Neighboring gene ribosomal protein S26 pseudogene 45 Neighboring gene long intergenic non-protein coding RNA 2373 Neighboring gene fibroblast growth factor receptor substrate 2 Neighboring gene small nucleolar RNA, H/ACA box 113

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog
Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
histone H2A acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
YEATS domain-containing protein 4
Names
NuMA binding protein 1
glioma-amplified sequence 41
nuBI1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052956.1 RefSeqGene

    Range
    5034..36161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300950.1NP_001287879.1  YEATS domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001287879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC000994, CA775118, CK820576, DN915967, U61384
    Consensus CDS
    CCDS73495.1
    UniProtKB/Swiss-Prot
    O95619
    UniProtKB/TrEMBL
    F8W0J4
    Related
    ENSP00000447199.1, ENST00000548020.5
  2. NM_006530.4NP_006521.1  YEATS domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_006521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117502, CK820576, DN915967, U61384
    Consensus CDS
    CCDS8990.1
    UniProtKB/Swiss-Prot
    O95619
    Related
    ENSP00000247843.2, ENST00000247843.7
    Conserved Domains (1) summary
    pfam03366
    Location:44123
    YEATS; YEATS family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    69359705..69427077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_944742.3 RNA Sequence

  2. XR_001748876.1 RNA Sequence

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