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YEATS4 YEATS domain containing 4 [ Homo sapiens (human) ]

Gene ID: 8089, updated on 7-Sep-2023

Summary

Official Symbol
YEATS4provided by HGNC
Official Full Name
YEATS domain containing 4provided by HGNC
Primary source
HGNC:HGNC:24859
See related
Ensembl:ENSG00000127337 MIM:602116; AllianceGenome:HGNC:24859
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
Summary
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Expression
Broad expression in testis (RPKM 7.3), bone marrow (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See YEATS4 in Genome Data Viewer
Location:
12q15
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (69359743..69462793)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (69338679..69442128)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69753523..69784650)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene C1GALT1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:69725950-69726664 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:69753267-69753870 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:69753871-69754472 Neighboring gene lysozyme Neighboring gene RNA, 7SL, cytoplasmic 804, pseudogene Neighboring gene Sharpr-MPRA regulatory regions 8384 and 8454 Neighboring gene ribosomal protein S26 pseudogene 45 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:69860555-69861168 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:69863839-69864340 Neighboring gene fibroblast growth factor receptor substrate 2 Neighboring gene small nucleolar RNA, H/ACA box 113 Neighboring gene microRNA 3913-1 Neighboring gene microRNA 3913-2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
EBI GWAS Catalog
Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
YEATS domain-containing protein 4
Names
NuMA binding protein 1
glioma-amplified sequence 41
nuBI1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052956.2 RefSeqGene

    Range
    5002..36129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300950.2NP_001287879.1  YEATS domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001287879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC000994, CA775118, CK820576, DN915967, U61384
    Consensus CDS
    CCDS73495.1
    UniProtKB/Swiss-Prot
    O95619
    UniProtKB/TrEMBL
    F8W0J4
    Related
    ENSP00000447199.1, ENST00000548020.5
    Conserved Domains (1) summary
    cl38902
    Location:19101
    YEATS; YEATS domain family, chromatin reader proteins
  2. NM_006530.4NP_006521.1  YEATS domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_006521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117502, CK820576, DN915967, U61384
    Consensus CDS
    CCDS8990.1
    UniProtKB/Swiss-Prot
    O95619, Q9NQD0
    Related
    ENSP00000247843.2, ENST00000247843.7
    Conserved Domains (1) summary
    cd16909
    Location:19155
    YEATS_GAS41_like; YEATS domain found in YEATS domain-containing protein 4 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    69359743..69462793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007063127.1 RNA Sequence

  2. XR_007063131.1 RNA Sequence

  3. XR_944742.4 RNA Sequence

  4. XR_007063126.1 RNA Sequence

  5. XR_007063128.1 RNA Sequence

  6. XR_007063129.1 RNA Sequence

  7. XR_001748876.2 RNA Sequence

  8. XR_007063130.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    69338679..69442128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008488686.1 RNA Sequence

  2. XR_008488682.1 RNA Sequence

  3. XR_008488683.1 RNA Sequence

  4. XR_008488681.1 RNA Sequence

  5. XR_008488685.1 RNA Sequence

  6. XR_008488684.1 RNA Sequence