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Slc16a3 solute carrier family 16 (monocarboxylic acid transporters), member 3 [ Mus musculus (house mouse) ]

Gene ID: 80879, updated on 9-Mar-2023

Summary

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Official Symbol
Slc16a3provided by MGI
Official Full Name
solute carrier family 16 (monocarboxylic acid transporters), member 3provided by MGI
Primary source
MGI:MGI:1933438
See related
Ensembl:ENSMUSG00000025161 AllianceGenome:MGI:1933438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mct3; Mct4
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in plasma membrane lactate transport. Predicted to be located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and nuclear membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and musculoskeletal system. Orthologous to human SLC16A3 (solute carrier family 16 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 14.2), duodenum adult (RPKM 13.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Slc16a3 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120839310..120849826)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120948484..120959000)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene fatty acid synthase Neighboring gene coiled-coil domain containing 57 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene casein kinase 1, delta Neighboring gene predicted gene, 53204 Neighboring gene predicted gene, 30062

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy. Renner K, et al. Cell Rep, 2019 Oct 1. PMID 31577944
  2. Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma. Zhao Y, et al. Exp Cell Res, 2019 Nov 1. PMID 31479685
  3. Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer. Bisetto S, et al. Front Oncol, 2018. PMID 30211114, Free PMC Article
  4. Prolonged hypoxia induces monocarboxylate transporter-4 expression in mesenchymal stem cells resulting in a secretome that is deleterious to cardiovascular repair. Saraswati S, et al. Stem Cells, 2015 Apr. PMID 25537659, Free PMC Article
  5. MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies. Baek G, et al. Cell Rep, 2014 Dec 24. PMID 25497091

See all (70) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lactate secreted via MCT4 from bonecolonizing breast cancer excites sensory neurons via GPR81.
    Title: Lactate secreted via MCT4 from bone‑colonizing breast cancer excites sensory neurons via GPR81.
  2. Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack.
    Title: Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack.
  3. Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
    Title: Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
  4. The MCT4-inhibition-induced disruption of tumor intracellular pH holds promise as a therapy against not only HCC.
    Title: Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma.
  5. MCT1 inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 and MCT4 via disruption of pyruvate rather than lactate export.
    Title: MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.
  6. This study demonstrated that MCT4 was up regulation in the brain afeter cerebral ischemia.
    Title: Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprograming taking place following cerebral ischemia.
  7. The soleus, liver and heart were the main tissues that showed improved the MCT1 mRNA expression, indicating its important role in controlling MLSS concentration in mice.
    Title: MCT1 and MCT4 kinetic of mRNA expression in different tissues after aerobic exercise at maximal lactate steady state workload.
  8. MCT4-overexpressing mesenchymal stem cells preferentially induced cell death in cardiomyocytes.
    Title: Prolonged hypoxia induces monocarboxylate transporter-4 expression in mesenchymal stem cells resulting in a secretome that is deleterious to cardiovascular repair.
  9. MCT4 depletion induced cell death characterized by elevated reactive oxygen species and metabolic crisis. In xenograft models, MCT4 had a significant impact on tumor metabolism and was required for rapid tumor growth.
    Title: MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies.
  10. MCT4 is up-regulated in inflammation-activated macrophages and required for innate immune response.
    Title: The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lactate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lactate:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables pyruvate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lactate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in plasma membrane lactate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pyruvate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyruvate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 4
Names
MCT 4
solute carrier family 16 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038653.1 → NP_001033742.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001033742.1

    Status: VALIDATED

    Source sequence(s)
    AK149707, AK166048
    Consensus CDS
    CCDS25761.1
    UniProtKB/Swiss-Prot
    P57787, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Related
    ENSMUSP00000125846.2, ENSMUST00000168579.8
    Conserved Domains (1) summary
    cd17430
    Location:21 → 410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

  2. NM_001038654.1 → NP_001033743.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001033743.1

    Status: VALIDATED

    Source sequence(s)
    AK149707, AK165596, AK166048
    Consensus CDS
    CCDS25761.1
    UniProtKB/Swiss-Prot
    P57787, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Related
    ENSMUSP00000097706.4, ENSMUST00000100130.10
    Conserved Domains (1) summary
    cd17430
    Location:21 → 410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

  3. NM_030696.3 → NP_109621.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_109621.1

    Status: VALIDATED

    Source sequence(s)
    AK166048, BC046525
    Consensus CDS
    CCDS25761.1
    UniProtKB/Swiss-Prot
    P57787, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Related
    ENSMUSP00000068854.7, ENSMUST00000070653.13
    Conserved Domains (1) summary
    cd17430
    Location:21 → 410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120839310..120849826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157107.1 → XP_036013000.1  monocarboxylate transporter 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESF8
    UniProtKB/TrEMBL
    Q3UDP9
    Conserved Domains (1) summary
    cd17430
    Location:21 → 410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

  2. XM_011249321.3 → XP_011247623.1  monocarboxylate transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_011247623.1

    UniProtKB/Swiss-Prot
    P57787, Q9ESF8
    UniProtKB/TrEMBL
    Q3UDP9
    Conserved Domains (1) summary
    cd17430
    Location:21 → 410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

  3. XM_011249322.4 → XP_011247624.1  monocarboxylate transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_011247624.1

    UniProtKB/Swiss-Prot
    P57787, Q9ESF8
    UniProtKB/TrEMBL
    Q3UDP9
    Conserved Domains (1) summary
    cd17430
    Location:21 → 410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57787.1 GenPept UniProtKB/Swiss-Prot:P57787

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