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Slc16a3 solute carrier family 16 (monocarboxylic acid transporters), member 3 [ Mus musculus (house mouse) ]

Gene ID: 80879, updated on 11-Jun-2024

Summary

Official Symbol
Slc16a3provided by MGI
Official Full Name
solute carrier family 16 (monocarboxylic acid transporters), member 3provided by MGI
Primary source
MGI:MGI:1933438
See related
Ensembl:ENSMUSG00000025161 AllianceGenome:MGI:1933438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mct3; Mct4
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in plasma membrane lactate transport. Predicted to be located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and nuclear membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and musculoskeletal system. Orthologous to human SLC16A3 (solute carrier family 16 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 14.2), duodenum adult (RPKM 13.7) and 22 other tissues See more
Orthologs
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Genomic context

See Slc16a3 in Genome Data Viewer
Location:
11 E2; 11 84.73 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120839310..120849826)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120948484..120959000)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304 Neighboring gene STARR-seq mESC enhancer starr_31376 Neighboring gene casein kinase 1, delta Neighboring gene STARR-positive B cell enhancer ABC_E8477 Neighboring gene predicted gene, 53204 Neighboring gene predicted gene, 30062

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lactate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lactate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lactate:proton symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables monocarboxylic acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables pyruvate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lactate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in plasma membrane lactate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pyruvate catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pyruvate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
monocarboxylate transporter 4
Names
MCT 4
solute carrier family 16 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038653.1NP_001033742.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001033742.1

    Status: VALIDATED

    Source sequence(s)
    AK149707, AK166048
    Consensus CDS
    CCDS25761.1
    UniProtKB/Swiss-Prot
    P57787, Q9ES80, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Related
    ENSMUSP00000125846.2, ENSMUST00000168579.8
    Conserved Domains (1) summary
    cd17430
    Location:21410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
  2. NM_001038654.1NP_001033743.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_001033743.1

    Status: VALIDATED

    Source sequence(s)
    AK149707, AK165596, AK166048
    Consensus CDS
    CCDS25761.1
    UniProtKB/Swiss-Prot
    P57787, Q9ES80, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Related
    ENSMUSP00000097706.4, ENSMUST00000100130.10
    Conserved Domains (1) summary
    cd17430
    Location:21410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
  3. NM_030696.3NP_109621.1  monocarboxylate transporter 4

    See identical proteins and their annotated locations for NP_109621.1

    Status: VALIDATED

    Source sequence(s)
    AK166048, BC046525
    Consensus CDS
    CCDS25761.1
    UniProtKB/Swiss-Prot
    P57787, Q9ES80, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Related
    ENSMUSP00000068854.7, ENSMUST00000070653.13
    Conserved Domains (1) summary
    cd17430
    Location:21410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120839310..120849826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157107.1XP_036013000.1  monocarboxylate transporter 4 isoform X1

    UniProtKB/Swiss-Prot
    P57787, Q9ES80, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Conserved Domains (1) summary
    cd17430
    Location:21410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
  2. XM_011249321.3XP_011247623.1  monocarboxylate transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_011247623.1

    UniProtKB/Swiss-Prot
    P57787, Q9ES80, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Conserved Domains (1) summary
    cd17430
    Location:21410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
  3. XM_011249322.4XP_011247624.1  monocarboxylate transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_011247624.1

    UniProtKB/Swiss-Prot
    P57787, Q9ES80, Q9ESF8
    UniProtKB/TrEMBL
    Q3TMA0, Q3UDP9
    Conserved Domains (1) summary
    cd17430
    Location:21410
    MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters