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Lrba LPS-responsive beige-like anchor [ Mus musculus (house mouse) ]

Gene ID: 80877, updated on 18-Apr-2024

Summary

Official Symbol
Lrbaprovided by MGI
Official Full Name
LPS-responsive beige-like anchorprovided by MGI
Primary source
MGI:MGI:1933162
See related
Ensembl:ENSMUSG00000028080 AllianceGenome:MGI:1933162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lba; Lab300; D3Ertd775e
Summary
Predicted to enable protein kinase A binding activity and protein kinase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is expressed in branchial arch; central nervous system; limb; sensory organ; and somite. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human LRBA (LPS responsive beige-like anchor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 5.1), large intestine adult (RPKM 4.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
3 F1; 3 37.83 cM
Exon count:
59
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (86130763..86690001)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (86223456..86782694)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9555 Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene ribosomal protein S3A1 Neighboring gene STARR-positive B cell enhancer ABC_E2073 Neighboring gene predicted gene, 23025 Neighboring gene STARR-seq mESC enhancer starr_08126 Neighboring gene predicted gene, 26343 Neighboring gene predicted gene, 40083 Neighboring gene predicted gene, 23850 Neighboring gene predicted gene, 25039 Neighboring gene predicted gene, 31677 Neighboring gene mab-21-like 2 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08131 Neighboring gene predicted gene, 52625 Neighboring gene STARR-seq mESC enhancer starr_08132 Neighboring gene STARR-positive B cell enhancer ABC_E6065 Neighboring gene STARR-seq mESC enhancer starr_08133 Neighboring gene doublecortin-like kinase 2 Neighboring gene predicted gene, 46810 Neighboring gene STARR-seq mESC enhancer starr_08138 Neighboring gene predicted gene, 23376

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase A binding ISA
Inferred from Sequence Alignment
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lipopolysaccharide-responsive and beige-like anchor protein
Names
beige-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077687.1NP_001071155.1  lipopolysaccharide-responsive and beige-like anchor protein isoform gamma

    Status: VALIDATED

    Source sequence(s)
    AC102270, AF187731, AF188507, AK035483, AK052148, CV556905
    Consensus CDS
    CCDS79934.1
    UniProtKB/Swiss-Prot
    Q9ESD3, Q9ESD4, Q9ESE1
    UniProtKB/TrEMBL
    A0A0A6YXX3
    Related
    ENSMUSP00000142179.2, ENSMUST00000192145.6
    Conserved Domains (6) summary
    cd00020
    Location:672790
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam02138
    Location:22042480
    Beach; Beige/BEACH domain
    pfam06469
    Location:18822049
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam14844
    Location:20752172
    PH_BEACH; PH domain associated with Beige/BEACH
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. NM_001077688.1NP_001071156.1  lipopolysaccharide-responsive and beige-like anchor protein isoform beta

    Status: VALIDATED

    Source sequence(s)
    AC102164, AC102270, AF187731, AF188506, AF188507, AK052148, CV556905
    Consensus CDS
    CCDS79933.1
    UniProtKB/Swiss-Prot
    Q9ESD3, Q9ESD4, Q9ESE1
    UniProtKB/TrEMBL
    A0A0A6YXL6
    Related
    ENSMUSP00000142043.2, ENSMUST00000194759.6
    Conserved Domains (9) summary
    COG2319
    Location:25382775
    WD40; WD40 repeat [General function prediction only]
    cd00020
    Location:672790
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam02138
    Location:22042480
    Beach; Beige/BEACH domain
    pfam06469
    Location:18822049
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam14844
    Location:20752172
    PH_BEACH; PH domain associated with Beige/BEACH
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:25912627
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:25962775
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  3. NM_030695.2NP_109620.2  lipopolysaccharide-responsive and beige-like anchor protein isoform alpha

    Status: VALIDATED

    Source sequence(s)
    AC102270, AF187731, AF188507, AK031216, AK052148, BQ031803, CV556905
    Consensus CDS
    CCDS38470.1
    UniProtKB/Swiss-Prot
    Q9ESD3, Q9ESD4, Q9ESE1
    UniProtKB/TrEMBL
    E9Q3Y4
    Related
    ENSMUSP00000103261.2, ENSMUST00000107635.7
    Conserved Domains (9) summary
    COG2319
    Location:25812848
    WD40; WD40 repeat [General function prediction only]
    cd00020
    Location:672790
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam02138
    Location:22042480
    Beach; Beige/BEACH domain
    pfam06469
    Location:18822049
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam14844
    Location:20752172
    PH_BEACH; PH domain associated with Beige/BEACH
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:25912627
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:25962796
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    86130763..86690001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502347.4XP_006502410.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X1

    See identical proteins and their annotated locations for XP_006502410.1

    UniProtKB/Swiss-Prot
    Q9ESD3, Q9ESD4, Q9ESE1
    Conserved Domains (7) summary
    sd00039
    Location:26082644
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:22162492
    Beach; Beige/BEACH domain
    pfam06469
    Location:18822061
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam14844
    Location:20872184
    PH_BEACH; PH domain associated with Beige/BEACH
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl29593
    Location:26132813
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006502349.4XP_006502412.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X2

    UniProtKB/Swiss-Prot
    Q9ESD3, Q9ESD4, Q9ESE1
    Conserved Domains (7) summary
    sd00039
    Location:26082644
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:22162492
    Beach; Beige/BEACH domain
    pfam06469
    Location:18822061
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam14844
    Location:20872184
    PH_BEACH; PH domain associated with Beige/BEACH
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl29593
    Location:26132812
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006502350.4XP_006502413.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X3

    UniProtKB/Swiss-Prot
    Q9ESD3, Q9ESD4, Q9ESE1
    Conserved Domains (7) summary
    sd00039
    Location:26032639
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:22162492
    Beach; Beige/BEACH domain
    pfam06469
    Location:18822061
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam14844
    Location:20872184
    PH_BEACH; PH domain associated with Beige/BEACH
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl29593
    Location:26082808
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006502351.4XP_006502414.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X4

    UniProtKB/Swiss-Prot
    Q9ESD3, Q9ESD4, Q9ESE1
    Conserved Domains (7) summary
    sd00039
    Location:25962632
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:22042480
    Beach; Beige/BEACH domain
    pfam06469
    Location:18822049
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam14844
    Location:20752172
    PH_BEACH; PH domain associated with Beige/BEACH
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl29593
    Location:26012801
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006502352.5XP_006502415.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X5

    UniProtKB/TrEMBL
    A0A1D5RM41
    Related
    ENSMUSP00000148618.2, ENSMUST00000212390.2
    Conserved Domains (4) summary
    pfam06469
    Location:18822061
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    cl17171
    Location:20802122
    PH-like; Pleckstrin homology-like domain
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  6. XM_006502348.4XP_006502411.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X1

    See identical proteins and their annotated locations for XP_006502411.1

    UniProtKB/Swiss-Prot
    Q9ESD3, Q9ESD4, Q9ESE1
    Conserved Domains (7) summary
    sd00039
    Location:26082644
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:22162492
    Beach; Beige/BEACH domain
    pfam06469
    Location:18822061
    DUF1088; Domain of Unknown Function (DUF1088)
    pfam14844
    Location:20872184
    PH_BEACH; PH domain associated with Beige/BEACH
    pfam15787
    Location:446717
    DUF4704; Domain of unknown function (DUF4704)
    cl22861
    Location:229376
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl29593
    Location:26132813
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_006502354.5XP_006502417.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X7

    UniProtKB/TrEMBL
    Q8BSM6
    Conserved Domains (4) summary
    sd00039
    Location:487523
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:95371
    Beach; Beige/BEACH domain
    cl17171
    Location:263
    PH-like; Pleckstrin homology-like domain
    cl29593
    Location:492692
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_006502353.3XP_006502416.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X6

    UniProtKB/TrEMBL
    Q8BSM6
    Related
    ENSMUSP00000141734.2, ENSMUST00000195524.2
    Conserved Domains (4) summary
    sd00039
    Location:515551
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:123399
    Beach; Beige/BEACH domain
    cl17171
    Location:1691
    PH-like; Pleckstrin homology-like domain
    cl29593
    Location:520720
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...