U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SH3BP5L SH3 binding domain protein 5 like [ Homo sapiens (human) ]

Gene ID: 80851, updated on 12-Aug-2022

Summary

Official Symbol
SH3BP5Lprovided by HGNC
Official Full Name
SH3 binding domain protein 5 likeprovided by HGNC
Primary source
HGNC:HGNC:29360
See related
Ensembl:ENSG00000175137 AllianceGenome:HGNC:29360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction and negative regulation of protein tyrosine kinase activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 5.3), brain (RPKM 5.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SH3BP5L in Genome Data Viewer
Location:
1q44
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248810446..248825915, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (248248930..248264398, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (249104645..249120114, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DPY19L4 pseudogene 1 Neighboring gene uncharacterized LOC124904577 Neighboring gene Sharpr-MPRA regulatory region 9626 Neighboring gene microRNA 3124 Neighboring gene zinc finger protein 672

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33845, KIAA1720

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SH3 domain-binding protein 5-like
Names
SH3BP-5-like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322462.1NP_001309391.1  SH3 domain-binding protein 5-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK125837, AL732583, BC010871
    UniProtKB/Swiss-Prot
    Q7L8J4
    Related
    ENST00000475978.1
    Conserved Domains (1) summary
    pfam05276
    Location:7157
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
  2. NM_001322463.1NP_001309392.1  SH3 domain-binding protein 5-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732583
    Conserved Domains (1) summary
    pfam05276
    Location:7157
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
  3. NM_001322464.2NP_001309393.1  SH3 domain-binding protein 5-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL732583
    Conserved Domains (1) summary
    pfam05276
    Location:27109
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
  4. NM_030645.3NP_085148.1  SH3 domain-binding protein 5-like isoform 1

    See identical proteins and their annotated locations for NP_085148.1

    Status: VALIDATED

    Source sequence(s)
    AK056382, AL136569
    Consensus CDS
    CCDS31126.1
    UniProtKB/Swiss-Prot
    Q7L8J4, Q9C0E3
    UniProtKB/TrEMBL
    A0A024R0T2
    Related
    ENSP00000355428.5, ENST00000366472.6
    Conserved Domains (1) summary
    pfam05276
    Location:55283
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    248810446..248825915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431089.1XP_047287045.1  SH3 domain-binding protein 5-like isoform X1

    UniProtKB/TrEMBL
    Q96MW4
  2. XM_047431109.1XP_047287065.1  SH3 domain-binding protein 5-like isoform X1

    UniProtKB/TrEMBL
    Q96MW4
  3. XM_047431099.1XP_047287055.1  SH3 domain-binding protein 5-like isoform X1

    UniProtKB/TrEMBL
    Q96MW4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    248248930..248264398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)