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TAS1R1 taste 1 receptor member 1 [ Homo sapiens (human) ]

Gene ID: 80835, updated on 1-Jun-2020

Summary

Official Symbol
TAS1R1provided by HGNC
Official Full Name
taste 1 receptor member 1provided by HGNC
Primary source
HGNC:HGNC:14448
See related
Ensembl:ENSG00000173662 MIM:606225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR1; T1R1; GM148; GPR70
Summary
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in testis (RPKM 1.2), gall bladder (RPKM 0.1) and 7 other tissues See more
Orthologs

Genomic context

See TAS1R1 in Genome Data Viewer
Location:
1p36.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (6555307..6579755)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6614987..6639817)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 25 Neighboring gene pleckstrin homology and RhoGEF domain containing G5 Neighboring gene nucleolar protein 9 Neighboring gene RNA, U6 small nuclear 731, pseudogene Neighboring gene uncharacterized LOC107984912 Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene kelch like family member 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
taste receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
detection of chemical stimulus involved in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
sensory perception of umami taste IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of umami taste IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IC
Inferred by Curator
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
taste receptor type 1 member 1
Names
G-protein coupled receptor 70
seven transmembrane helix receptor
taste receptor, type 1, member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138697.4NP_619642.2  taste receptor type 1 member 1 isoform b precursor

    See identical proteins and their annotated locations for NP_619642.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).
    Source sequence(s)
    AI742401, AL591866, BC136515, BC136516
    Consensus CDS
    CCDS81.1
    UniProtKB/Swiss-Prot
    Q7RTX1
    Related
    ENSP00000331867.6, ENST00000333172.11
    Conserved Domains (4) summary
    cd06363
    Location:32486
    PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
    pfam00003
    Location:588814
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74457
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:495544
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. NM_177540.3NP_803884.1  taste receptor type 1 member 1 isoform c precursor

    See identical proteins and their annotated locations for NP_803884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 2, resulting in an isoform (c) which is shorter but has the same N- and C-termini compared to isoform b.
    Source sequence(s)
    AI742401, AK292014, AL591866, BC136515
    Consensus CDS
    CCDS82.1
    UniProtKB/Swiss-Prot
    Q7RTX1
    UniProtKB/TrEMBL
    A8K7J9
    Related
    ENSP00000312558.5, ENST00000351136.7
    Conserved Domains (3) summary
    pfam00003
    Location:334560
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam07562
    Location:241290
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:32166
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    6555307..6579755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542203.2XP_011540505.1  taste receptor type 1 member 1 isoform X2

    See identical proteins and their annotated locations for XP_011540505.1

    Conserved Domains (4) summary
    pfam00003
    Location:510736
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:1379
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:417466
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1408
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  2. XM_017002402.1XP_016857891.1  taste receptor type 1 member 1 isoform X1

  3. XM_017002403.1XP_016857892.1  taste receptor type 1 member 1 isoform X3

  4. XM_011542206.2XP_011540508.1  taste receptor type 1 member 1 isoform X4

    Conserved Domains (3) summary
    cd06363
    Location:66488
    PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
    pfam01094
    Location:76459
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:497542
    NCD3G; Nine Cysteines Domain of family 3 GPCR

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177539.1: Suppressed sequence

    Description
    NM_177539.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_177541.1: Suppressed sequence

    Description
    NM_177541.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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