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TAS1R2 taste 1 receptor member 2 [ Homo sapiens (human) ]

Gene ID: 80834, updated on 13-Nov-2022

Summary

Official Symbol
TAS1R2provided by HGNC
Official Full Name
taste 1 receptor member 2provided by HGNC
Primary source
HGNC:HGNC:14905
See related
Ensembl:ENSG00000179002 MIM:606226; AllianceGenome:HGNC:14905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR2; T1R2; GPR71
Summary
Contributes to sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste and positive regulation of cytokinesis. Part of sweet taste receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TAS1R2 in Genome Data Viewer
Location:
1p36.13
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (18839599..18859660, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (18659394..18679451, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19166093..19186154, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PAX7 intron homotypic clusters of transcription factor binding sites enhancer Neighboring gene Sharpr-MPRA regulatory region 1855 Neighboring gene paired box 7 Neighboring gene Sharpr-MPRA regulatory region 7483 Neighboring gene aldehyde dehydrogenase 4 family member A1 Neighboring gene microRNA 4695

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variants associated with disordered eating.
EBI GWAS Catalog
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to sweet taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to sweet taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables taste receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of sweet taste receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of sweet taste receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
taste receptor type 1 member 2
Names
G-protein coupled receptor 71
sweet taste receptor T1R2
taste receptor, type 1, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152232.6NP_689418.2  taste receptor type 1 member 2 precursor

    See identical proteins and their annotated locations for NP_689418.2

    Status: VALIDATED

    Source sequence(s)
    AL831755, BX537160
    Consensus CDS
    CCDS187.1
    UniProtKB/Swiss-Prot
    Q5TZ19, Q8TE23
    Related
    ENSP00000364520.3, ENST00000375371.4
    Conserved Domains (4) summary
    cd06363
    Location:27484
    PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
    pfam00003
    Location:577814
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:70454
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:493543
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    18839599..18859660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    18659394..18679451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)