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TAS1R2 taste 1 receptor member 2 [ Homo sapiens (human) ]

Gene ID: 80834, updated on 1-Jun-2020

Summary

Official Symbol
TAS1R2provided by HGNC
Official Full Name
taste 1 receptor member 2provided by HGNC
Primary source
HGNC:HGNC:14905
See related
Ensembl:ENSG00000179002 MIM:606226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR2; T1R2; GPR71
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TAS1R2 in Genome Data Viewer
Location:
1p36.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (18839599..18859660, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19166093..19186155, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PAX7 promoter region Neighboring gene PAX7 intron homotypic clusters of transcription factor binding sites enhancer Neighboring gene paired box 7 Neighboring gene aldehyde dehydrogenase 4 family member A1 Neighboring gene microRNA 4695 Neighboring gene microRNA 1290

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to sweet taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to sweet taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
taste receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IC
Inferred by Curator
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
sweet taste receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sweet taste receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
taste receptor type 1 member 2
Names
G-protein coupled receptor 71
sweet taste receptor T1R2
taste receptor, type 1, member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152232.4NP_689418.2  taste receptor type 1 member 2 precursor

    See identical proteins and their annotated locations for NP_689418.2

    Status: VALIDATED

    Source sequence(s)
    AL831755, BX537160
    Consensus CDS
    CCDS187.1
    UniProtKB/Swiss-Prot
    Q8TE23
    Related
    ENSP00000364520.3, ENST00000375371.3
    Conserved Domains (4) summary
    cd06363
    Location:27484
    PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
    pfam00003
    Location:577814
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:70454
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:493543
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    18839599..18859660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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