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APOL4 apolipoprotein L4 [ Homo sapiens (human) ]

Gene ID: 80832, updated on 11-Sep-2019

Summary

Official Symbol
APOL4provided by HGNC
Official Full Name
apolipoprotein L4provided by HGNC
Primary source
HGNC:HGNC:14867
See related
Ensembl:ENSG00000100336 MIM:607254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOLIV; APOL-IV
Summary
The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 5.7), lung (RPKM 5.4) and 24 other tissues See more
Orthologs

Genomic context

See APOL4 in Genome Data Viewer
Location:
22q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (36189128..36204833, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36585176..36600879, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MT-CYB pseudogene 34 Neighboring gene MT-ND1 pseudogene 10 Neighboring gene apolipoprotein L2 Neighboring gene apolipoprotein L1 Neighboring gene uncharacterized LOC112268296

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
apolipoprotein L4
Names
apolipoprotein L, 4
apolipoprotein L-IV

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023437.1 RefSeqGene

    Range
    5001..20706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030643.4NP_085146.2  apolipoprotein L4 isoform 1

    See identical proteins and their annotated locations for NP_085146.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longer transcript but encodes a shorter isoform (1).
    Source sequence(s)
    AW627682, AY014914, DA865632, Z95114
    Consensus CDS
    CCDS74851.1
    UniProtKB/Swiss-Prot
    Q9BPW4
    Related
    ENSP00000483497.1, ENST00000616056.4
    Conserved Domains (1) summary
    pfam05461
    Location:57345
    ApoL; Apolipoprotein L
  2. NM_145660.2NP_663693.1  apolipoprotein L4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_663693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) lacks an internal exon in the 5' region, which results in upstream AUG start codon, compared to variant a. The resulting isoform (2) has a longer and distinct N-terminus, compared to isoform 1. Isoform 2 is thought to be a secreted protein.
    Source sequence(s)
    AW627682, AY014914, AY014915, DA865632, Z95114
    Consensus CDS
    CCDS74852.1
    UniProtKB/Swiss-Prot
    Q9BPW4
    Related
    ENSP00000338260.3, ENST00000352371.5
    Conserved Domains (1) summary
    pfam05461
    Location:60348
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    36189128..36204833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452274.1XP_024308042.1  apolipoprotein L4 isoform X1

    Conserved Domains (1) summary
    pfam05461
    Location:1252
    ApoL; Apolipoprotein L
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