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APOL5 apolipoprotein L5 [ Homo sapiens (human) ]

Gene ID: 80831, updated on 3-Mar-2026
Official Symbol
APOL5provided by HGNC
Official Full Name
apolipoprotein L5provided by HGNC
Primary source
HGNC:HGNC:14869
See related
Ensembl:ENSG00000128313 MIM:607255; AllianceGenome:HGNC:14869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOLV; APOL-V
Summary
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See APOL5 in Genome Data Viewer
Location:
22q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (35708424..35729483)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (36168169..36189236)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36113919..36125530)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18914 Neighboring gene apolipoprotein L6 Neighboring gene mitochondrial ribosomal protein S16 pseudogene 3 Neighboring gene RNA binding fox-1 homolog 2 Neighboring gene ribosomal protein L41 pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:36278945-36279446 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. Page NM, et al. Genomics, 2001 May 15. PMID 11374903
  2. EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. Namjou B, et al. Front Genet, 2013. PMID 24348519, Free PMC Article
  3. Genetic associations of brain structural networks in schizophrenia: a preliminary study. Jagannathan K, et al. Biol Psychiatry, 2010 Oct 1. PMID 20691427, Free PMC Article
  4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Ruaño G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615, Free PMC Article
  5. The DNA sequence of human chromosome 22. Dunham I, et al. Nature, 1999 Dec 2. PMID 10591208

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic associations of brain structural networks in schizophrenia: a preliminary study.
  2. APOL5 has been found only in humans
    Title: The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables high-density lipoprotein particle binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
apolipoprotein L5
Names
apolipoprotein L, 5
apolipoprotein L-V

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030642.1 → NP_085145.1  apolipoprotein L5

    See identical proteins and their annotated locations for NP_085145.1

    Status: REVIEWED

    Source sequence(s)
    AY014878
    Consensus CDS
    CCDS13920.1
    UniProtKB/Swiss-Prot
    Q5TFL9, Q9BWW9, Q9UGW5
    UniProtKB/TrEMBL
    A0A0G2JME4
    Related
    ENSP00000249044.2, ENST00000249044.2
    Conserved Domains (1) summary
    pfam05461
    Location:55 → 350
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    35708424..35729483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724321.5 → XP_006724384.1  apolipoprotein L5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JME4
    Conserved Domains (1) summary
    pfam05461
    Location:39 → 334
    ApoL; Apolipoprotein L

  2. XM_017028945.3 → XP_016884434.1  apolipoprotein L5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JME4

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187630.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    23191..44250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329449.1 → XP_054185424.1  apolipoprotein L5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JME4

  2. XM_054329450.1 → XP_054185425.1  apolipoprotein L5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JME4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    36168169..36189236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325944.1 → XP_054181919.1  apolipoprotein L5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JME4

  2. XM_054325945.1 → XP_054181920.1  apolipoprotein L5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JME4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWW9.1 GenPept UniProtKB/Swiss-Prot:Q9BWW9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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