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APOL5 apolipoprotein L5 [ Homo sapiens (human) ]

Gene ID: 80831, updated on 25-Jan-2022

Summary

Official Symbol
APOL5provided by HGNC
Official Full Name
apolipoprotein L5provided by HGNC
Primary source
HGNC:HGNC:14869
See related
Ensembl:ENSG00000128313 MIM:607255; AllianceGenome:HGNC:14869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOLV; APOL-V
Summary
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See APOL5 in Genome Data Viewer
Location:
22q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (35708424..35730325)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36113919..36125530)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene apolipoprotein L6 Neighboring gene mitochondrial ribosomal protein S16 pseudogene 3 Neighboring gene RNA binding fox-1 homolog 2 Neighboring gene ribosomal protein L41 pseudogene 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables high-density lipoprotein particle binding NAS
Non-traceable Author Statement
more info
PubMed 
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
apolipoprotein L5
Names
apolipoprotein L, 5
apolipoprotein L-V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030642.1NP_085145.1  apolipoprotein L5

    See identical proteins and their annotated locations for NP_085145.1

    Status: REVIEWED

    Source sequence(s)
    AY014878
    Consensus CDS
    CCDS13920.1
    UniProtKB/Swiss-Prot
    Q9BWW9
    Related
    ENSP00000249044.2, ENST00000249044.2
    Conserved Domains (1) summary
    pfam05461
    Location:55350
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    35708424..35730325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724321.4XP_006724384.1  apolipoprotein L5 isoform X1

    Conserved Domains (1) summary
    pfam05461
    Location:39334
    ApoL; Apolipoprotein L
  2. XM_017028945.2XP_016884434.1  apolipoprotein L5 isoform X2

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187630.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    32639..44250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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