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APOL6 apolipoprotein L6 [ Homo sapiens (human) ]

Gene ID: 80830, updated on 12-Oct-2019

Summary

Official Symbol
APOL6provided by HGNC
Official Full Name
apolipoprotein L6provided by HGNC
Primary source
HGNC:HGNC:14870
See related
Ensembl:ENSG00000221963 MIM:607256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOLVI; APOL-VI
Summary
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 14.3), liver (RPKM 13.1) and 24 other tissues See more
Orthologs

Genomic context

See APOL6 in Genome Data Viewer
Location:
22q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (35648316..35668406)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36044424..36064456)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene myoglobin Neighboring gene uncharacterized LOC284912 Neighboring gene mitochondrial ribosomal protein S16 pseudogene 3 Neighboring gene apolipoprotein L5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Infectious wild type HIV-1 production is restricted by 293T cells over-expressing APOL6 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of apolipoprotein L, 6 (APOL6) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38562, FLJ90164, MGC57495, DKFZp667M075

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
lipid transport IEA
Inferred from Electronic Annotation
more info
 
lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
apolipoprotein L6
Names
apolipoprotein L, 6
apolipoprotein L-VI

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030641.4NP_085144.1  apolipoprotein L6

    See identical proteins and their annotated locations for NP_085144.1

    Status: REVIEWED

    Source sequence(s)
    BC047864, BM982940, Z79996
    Consensus CDS
    CCDS13919.1
    UniProtKB/Swiss-Prot
    Q9BWW8
    UniProtKB/TrEMBL
    B3KTP4
    Related
    ENSP00000386280.3, ENST00000409652.5
    Conserved Domains (1) summary
    pfam05461
    Location:14292
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    35648316..35668406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530392.3XP_011528694.1  apolipoprotein L6 isoform X1

    See identical proteins and their annotated locations for XP_011528694.1

    UniProtKB/Swiss-Prot
    Q9BWW8
    UniProtKB/TrEMBL
    B3KTP4
    Conserved Domains (1) summary
    pfam05461
    Location:14292
    ApoL; Apolipoprotein L
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