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DUSP16 dual specificity phosphatase 16 [ Homo sapiens (human) ]

Gene ID: 80824, updated on 13-Mar-2020

Summary

Official Symbol
DUSP16provided by HGNC
Official Full Name
dual specificity phosphatase 16provided by HGNC
Primary source
HGNC:HGNC:17909
See related
Ensembl:ENSG00000111266 MIM:607175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKP7; MKP-7
Summary
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
Expression
Ubiquitous expression in adrenal (RPKM 19.6), liver (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See DUSP16 in Genome Data Viewer
Location:
12p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (12473282..12562863, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12626216..12715773, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene loss of heterozygosity on chromosome 12, region 2 Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene Neighboring gene uncharacterized LOC107984485 Neighboring gene uncharacterized LOC107984486 Neighboring gene ribosomal protein L19 pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dual specificity phosphatase 16 (DUSP16) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36298, FLJ40991, KIAA1700, MGC129701, MGC129702

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK export from nucleus TAS
Traceable Author Statement
more info
PubMed 
MAPK phosphatase export from nucleus, leptomycin B sensitive TAS
Traceable Author Statement
more info
PubMed 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
inactivation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inactivation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 16
Names
MAP kinase phosphatase 7
MAPK phosphatase-7
mitogen-activated protein kinase phosphatase 7
NP_085143.1
XP_005253545.1
XP_006719218.1
XP_011519158.1
XP_016875477.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021402.2 RefSeqGene

    Range
    4652..94233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030640.3NP_085143.1  dual specificity protein phosphatase 16

    See identical proteins and their annotated locations for NP_085143.1

    Status: REVIEWED

    Source sequence(s)
    AC007619, AC092824, AF506796, DB094627
    Consensus CDS
    CCDS8650.1
    UniProtKB/Swiss-Prot
    Q9BY84
    UniProtKB/TrEMBL
    A0A024RAR2
    Related
    ENSP00000298573.5, ENST00000298573.9
    Conserved Domains (3) summary
    COG2453
    Location:207300
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:158295
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    12473282..12562863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253488.3XP_005253545.1  dual specificity protein phosphatase 16 isoform X2

    See identical proteins and their annotated locations for XP_005253545.1

    Conserved Domains (2) summary
    COG2453
    Location:59152
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:29147
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. XM_017019988.1XP_016875477.1  dual specificity protein phosphatase 16 isoform X2

    Conserved Domains (2) summary
    COG2453
    Location:59152
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:29147
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  3. XM_006719155.2XP_006719218.1  dual specificity protein phosphatase 16 isoform X1

    See identical proteins and their annotated locations for XP_006719218.1

    UniProtKB/Swiss-Prot
    Q9BY84
    UniProtKB/TrEMBL
    A0A024RAR2
    Conserved Domains (3) summary
    COG2453
    Location:207300
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:158295
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
  4. XM_011520856.1XP_011519158.1  dual specificity protein phosphatase 16 isoform X1

    See identical proteins and their annotated locations for XP_011519158.1

    UniProtKB/Swiss-Prot
    Q9BY84
    UniProtKB/TrEMBL
    A0A024RAR2
    Conserved Domains (3) summary
    COG2453
    Location:207300
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:158295
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_011332696.1 Reference GRCh38.p13 PATCHES

    Range
    442285..531866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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