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Cblc Casitas B-lineage lymphoma c [ Mus musculus (house mouse) ]

Gene ID: 80794, updated on 4-Jun-2024

Summary

Official Symbol
Cblcprovided by MGI
Official Full Name
Casitas B-lineage lymphoma cprovided by MGI
Primary source
MGI:MGI:1931457
See related
Ensembl:ENSMUSG00000040525 AllianceGenome:MGI:1931457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbl3; 2310076I21Rik; 2310079L19Rik
Summary
Predicted to enable several functions, including SH3 domain binding activity; phosphotyrosine residue binding activity; and signaling receptor binding activity. Predicted to be involved in cellular protein metabolic process; negative regulation of protein kinase activity; and signal transduction. Predicted to be part of ubiquitin ligase complex. Predicted to be active in membrane raft and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Orthologous to human CBLC (Cbl proto-oncogene C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 57.9), duodenum adult (RPKM 51.4) and 10 other tissues See more
Orthologs
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Genomic context

See Cblc in Genome Data Viewer
Location:
7 A3; 7 9.94 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19513643..19530734, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19779718..19796809, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene STARR-seq mESC enhancer starr_18217 Neighboring gene STARR-seq mESC enhancer starr_18218 Neighboring gene predicted gene, 34744 Neighboring gene STARR-seq mESC enhancer starr_18221 Neighboring gene basal cell adhesion molecule Neighboring gene STARR-positive B cell enhancer ABC_E2816 Neighboring gene STARR-seq mESC enhancer starr_18223 Neighboring gene STARR-positive B cell enhancer ABC_E1721 Neighboring gene B cell leukemia/lymphoma 3 Neighboring gene predicted gene 16174 Neighboring gene predicted gene, 34891 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20426963-20427193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20429933-20430166 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20430230-20430572

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC117886

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epidermal growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to glial cell derived neurotrophic factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase CBL-C
Names
CBL-3
RING-type E3 ubiquitin transferase CBL-C
SH3-binding protein CBL-3
SH3-binding protein CBL-C
signal transduction protein CBL-C
NP_001155316.1
NP_075713.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161844.1NP_001155316.1  E3 ubiquitin-protein ligase CBL-C isoform 2

    See identical proteins and their annotated locations for NP_001155316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC149282
    Consensus CDS
    CCDS52064.1
    UniProtKB/TrEMBL
    G3X9U0, Q2TA94
    Related
    ENSMUSP00000104088.3, ENSMUST00000108449.9
    Conserved Domains (3) summary
    cd09920
    Location:225321
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02262
    Location:16144
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:148231
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  2. NM_023224.5NP_075713.3  E3 ubiquitin-protein ligase CBL-C isoform 1

    See identical proteins and their annotated locations for NP_075713.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK010228, BE198430, BQ031029
    Consensus CDS
    CCDS39804.1
    UniProtKB/Swiss-Prot
    Q80XL1, Q99PB6, Q9D6L2, Q9D7A9
    UniProtKB/TrEMBL
    Q2TA94
    Related
    ENSMUSP00000039955.8, ENSMUST00000043822.8
    Conserved Domains (4) summary
    cd09920
    Location:225321
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:350392
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02262
    Location:16144
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:148231
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19513643..19530734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)