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CMIP c-Maf inducing protein [ Homo sapiens (human) ]

Gene ID: 80790, updated on 11-Sep-2019

Summary

Official Symbol
CMIPprovided by HGNC
Official Full Name
c-Maf inducing proteinprovided by HGNC
Primary source
HGNC:HGNC:24319
See related
Ensembl:ENSG00000153815 MIM:610112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCMIP
Summary
This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in brain (RPKM 12.0), small intestine (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See CMIP in Genome Data Viewer
Location:
16q23.2-q23.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (81445170..81711762)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (81478775..81745367)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene microRNA 4720 Neighboring gene Sharpr-MPRA regulatory region 12949 Neighboring gene Sharpr-MPRA regulatory region 2416 Neighboring gene peptidylprolyl isomerase A pseudogene 51 Neighboring gene microRNA 7854 Neighboring gene HNF4 motif-containing MPRA enhancer 117 Neighboring gene uncharacterized LOC105371362 Neighboring gene microRNA 6504 Neighboring gene uncharacterized LOC100129617 Neighboring gene Sharpr-MPRA regulatory region 4528 Neighboring gene Sharpr-MPRA regulatory region 4151

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
NHGRI GWA Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
NHGRI GWA Catalog
Genome wide association study of age at menarche in the Japanese population.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
NHGRI GWA Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1694

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
C-Maf-inducing protein
Names
tc-Mip

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029839.1 RefSeqGene

    Range
    5001..271593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030629.3NP_085132.1  C-Maf-inducing protein isoform Tc-Mip

    See identical proteins and their annotated locations for NP_085132.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (Tc-Mip) with a distinct N-terminus compared to isoform C-Mip. This isoform lacks the NH2-terminal PH domain, is specifically recruited to PBMCs in MCNS patients, and thought to play a role in T-cell signaling pathway.
    Source sequence(s)
    AY172689, BM789770
    Consensus CDS
    CCDS54045.1
    UniProtKB/Swiss-Prot
    Q8IY22
    Related
    ENSP00000440401.2, ENST00000539778.6
    Conserved Domains (2) summary
    sd00034
    Location:570593
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:500674
    AMN1; Antagonist of mitotic exit network protein 1
  2. NM_198390.2NP_938204.2  C-Maf-inducing protein isoform C-Mip

    See identical proteins and their annotated locations for NP_938204.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (C-Mip). This variant is predominantly expressed in fetal liver, kidney, and peripheral blood mononuclear cells (PBMCs), but weakly detected in PBMCs from minimal change nephrotic syndrome (MCNS) patients.
    Source sequence(s)
    AB051481, BM789770, CV570964
    Consensus CDS
    CCDS54044.1
    UniProtKB/Swiss-Prot
    Q8IY22
    Related
    ENSP00000446100.2, ENST00000537098.7
    Conserved Domains (2) summary
    sd00034
    Location:664687
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:594768
    AMN1; Antagonist of mitotic exit network protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    81445170..81711762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523352.1XP_011521654.1  C-Maf-inducing protein isoform X1

    See identical proteins and their annotated locations for XP_011521654.1

    Conserved Domains (2) summary
    sd00034
    Location:648671
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl26161
    Location:647755
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_005256179.5XP_005256236.4  C-Maf-inducing protein isoform X2

  3. XM_005256181.2XP_005256238.1  C-Maf-inducing protein isoform X3

    See identical proteins and their annotated locations for XP_005256238.1

    UniProtKB/TrEMBL
    A0A087WU05
    Related
    ENSP00000478272.1, ENST00000566513.5
    Conserved Domains (2) summary
    sd00034
    Location:477500
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:442581
    AMN1; Antagonist of mitotic exit network protein 1
  4. XM_017023733.1XP_016879222.1  C-Maf-inducing protein isoform X3

    UniProtKB/TrEMBL
    A0A087WU05
    Conserved Domains (2) summary
    sd00034
    Location:477500
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:442581
    AMN1; Antagonist of mitotic exit network protein 1
  5. XM_011523353.1XP_011521655.1  C-Maf-inducing protein isoform X3

    See identical proteins and their annotated locations for XP_011521655.1

    UniProtKB/TrEMBL
    A0A087WU05
    Related
    ENSP00000381120.4, ENST00000398040.8
    Conserved Domains (2) summary
    sd00034
    Location:477500
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:442581
    AMN1; Antagonist of mitotic exit network protein 1
  6. XM_005256182.1XP_005256239.1  C-Maf-inducing protein isoform X3

    See identical proteins and their annotated locations for XP_005256239.1

    UniProtKB/TrEMBL
    A0A087WU05
    Conserved Domains (2) summary
    sd00034
    Location:477500
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:442581
    AMN1; Antagonist of mitotic exit network protein 1
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