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INTS5 integrator complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 80789, updated on 5-Aug-2026
Official Symbol
INTS5provided by HGNC
Official Full Name
integrator complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:29352
See related
Ensembl:ENSG00000185085 MIM:611349; AllianceGenome:HGNC:29352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT5; KIAA1698
Summary
The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in ovary (RPKM 6.3), thyroid (RPKM 6.0) and 25 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See INTS5 in Genome Data Viewer
Location:
11q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62646848..62653302, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62636300..62642755, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62414320..62420774, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62384118-62384618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62384619-62385119 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62388711-62389304 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62391987-62392312 Neighboring gene glucosidase II alpha subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62412284-62413091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62420185-62420944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4834 Neighboring gene chromosome 11 open reading frame 98 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene citrate synthase lysine methyltransferase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Structural basis of Integrator-mediated transcription regulation. Fianu I, et al. Science, 2021 Nov 12. PMID 34762484
  2. Structural basis of INTAC-regulated transcription. Zheng H, et al. Protein Cell, 2023 Sep 14. PMID 36869814, Free PMC Article
  3. Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Zheng H, et al. Science, 2020 Nov 27. PMID 33243860
  4. Structure of the catalytic core of the Integrator complex. Pfleiderer MM, et al. Mol Cell, 2021 Mar 18. PMID 33548203, Free PMC Article
  5. A combinatorial approach to uncover an additional Integrator subunit. Offley SR, et al. Cell Rep, 2023 Mar 28. PMID 36920904, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: LBHD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II transcription initiation surveillance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of INTAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of INTAC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of integrator complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
integrator complex subunit 5

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030628.2 → NP_085131.1  integrator complex subunit 5

    See identical proteins and their annotated locations for NP_085131.1

    Status: REVIEWED

    Source sequence(s)
    BC060841
    Consensus CDS
    CCDS8027.1
    UniProtKB/Swiss-Prot
    Q6P9B9, Q8N6W5, Q9C0G5
    Related
    ENSP00000327889.2, ENST00000330574.2
    Conserved Domains (2) summary
    pfam14837
    Location:29 → 251
    INTS5_N; Integrator complex subunit 5 N-terminus
    pfam14838
    Location:290 → 999
    INTS5_C; Integrator complex subunit 5 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62646848..62653302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62636300..62642755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9B9.1 GenPept UniProtKB/Swiss-Prot:Q6P9B9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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