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ZNF34 zinc finger protein 34 [ Homo sapiens (human) ]

Gene ID: 80778, updated on 8-Dec-2022

Summary

Official Symbol
ZNF34provided by HGNC
Official Full Name
zinc finger protein 34provided by HGNC
Primary source
HGNC:HGNC:13098
See related
Ensembl:ENSG00000196378 MIM:194526; AllianceGenome:HGNC:13098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX32
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 2.4), thyroid (RPKM 1.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF34 in Genome Data Viewer
Location:
8q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144772224..144787317, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145945720..145960823, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145997609..146012702, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375805 Neighboring gene Sharpr-MPRA regulatory region 4846 Neighboring gene Sharpr-MPRA regulatory region 10254 Neighboring gene RNA, 7SL, cytoplasmic 395, pseudogene Neighboring gene microRNA 6850 Neighboring gene ribosomal protein L8 Neighboring gene zinc finger protein 517 Neighboring gene uncharacterized LOC100130027

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10520

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 34
Names
zinc finger protein 34 (KOX 32)
zinc finger protein KOX32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286769.2NP_001273698.1  zinc finger protein 34 isoform 2

    See identical proteins and their annotated locations for NP_001273698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF235103, AL833814, W43004
    Consensus CDS
    CCDS69562.1
    UniProtKB/Swiss-Prot
    Q8IZ26
    UniProtKB/TrEMBL
    A0A0C4DG42
    Related
    ENSP00000396894.2, ENST00000429371.7
    Conserved Domains (3) summary
    smart00349
    Location:1476
    KRAB; krueppel associated box
    COG5048
    Location:167533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372392
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001286770.2NP_001273699.1  zinc finger protein 34 isoform 3

    See identical proteins and their annotated locations for NP_001273699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF235103, BP199961, W43004
    Conserved Domains (6) summary
    smart00349
    Location:35101
    KRAB; krueppel associated box
    COG5048
    Location:148514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:353373
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:267289
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3574
    KRAB; KRAB box
    pfam13465
    Location:421446
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001378027.1NP_001364956.1  zinc finger protein 34 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF235103
    Consensus CDS
    CCDS69562.1
    UniProtKB/TrEMBL
    A0A0C4DG42
    Conserved Domains (3) summary
    smart00349
    Location:1476
    KRAB; krueppel associated box
    COG5048
    Location:167533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372392
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001378028.1NP_001364957.1  zinc finger protein 34 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF235103
    Consensus CDS
    CCDS69562.1
    UniProtKB/TrEMBL
    A0A0C4DG42
    Conserved Domains (3) summary
    smart00349
    Location:1476
    KRAB; krueppel associated box
    COG5048
    Location:167533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372392
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001378029.1NP_001364958.1  zinc finger protein 34 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF235103
    Conserved Domains (3) summary
    smart00349
    Location:1480
    KRAB; krueppel associated box
    COG5048
    Location:127493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332352
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_030580.5NP_085057.3  zinc finger protein 34 isoform 1

    See identical proteins and their annotated locations for NP_085057.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF235103, BC004480, W43004
    Consensus CDS
    CCDS47945.1
    UniProtKB/Swiss-Prot
    Q8IZ26, Q9BSZ0
    Related
    ENSP00000341528.4, ENST00000343459.8
    Conserved Domains (6) summary
    smart00349
    Location:3597
    KRAB; krueppel associated box
    COG5048
    Location:188554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3574
    KRAB; KRAB box
    pfam13465
    Location:461486
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144772224..144787317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422270.1XP_047278226.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    Q9BSZ0
  2. XM_047422271.1XP_047278227.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    Q9BSZ0
  3. XM_047422274.1XP_047278230.1  zinc finger protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DG42
  4. XM_047422269.1XP_047278225.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    Q9BSZ0
  5. XM_047422272.1XP_047278228.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    Q9BSZ0
  6. XM_011517314.3XP_011515616.1  zinc finger protein 34 isoform X1

    See identical proteins and their annotated locations for XP_011515616.1

    UniProtKB/Swiss-Prot
    Q8IZ26, Q9BSZ0
    Conserved Domains (6) summary
    smart00349
    Location:3597
    KRAB; krueppel associated box
    COG5048
    Location:188554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3574
    KRAB; KRAB box
    pfam13465
    Location:461486
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011517318.3XP_011515620.1  zinc finger protein 34 isoform X2

    See identical proteins and their annotated locations for XP_011515620.1

    UniProtKB/Swiss-Prot
    Q8IZ26
    UniProtKB/TrEMBL
    A0A0C4DG42
    Conserved Domains (3) summary
    smart00349
    Location:1476
    KRAB; krueppel associated box
    COG5048
    Location:167533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372392
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_047422273.1XP_047278229.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    Q9BSZ0
  9. XM_047422275.1XP_047278231.1  zinc finger protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DG42
  10. XM_047422276.1XP_047278232.1  zinc finger protein 34 isoform X3

  11. XM_017013874.2XP_016869363.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZ26, Q9BSZ0
    Conserved Domains (6) summary
    smart00349
    Location:3597
    KRAB; krueppel associated box
    COG5048
    Location:188554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3574
    KRAB; KRAB box
    pfam13465
    Location:461486
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145945720..145960823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)