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ZNF34 zinc finger protein 34 [ Homo sapiens (human) ]

Gene ID: 80778, updated on 3-Mar-2026
Official Symbol
ZNF34provided by HGNC
Official Full Name
zinc finger protein 34provided by HGNC
Primary source
HGNC:HGNC:13098
See related
Ensembl:ENSG00000196378 MIM:194526; AllianceGenome:HGNC:13098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX32
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in ovary (RPKM 2.4), thyroid (RPKM 1.9) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ZNF34 in Genome Data Viewer
Location:
8q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144772224..144787317, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145945720..145960823, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145997609..146012702, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 251 Neighboring gene uncharacterized LOC107986986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145987405-145988352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145990589-145991192 Neighboring gene uncharacterized LOC105375805 Neighboring gene Sharpr-MPRA regulatory region 4846 Neighboring gene Sharpr-MPRA regulatory region 10254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28103 Neighboring gene RNA, 7SL, cytoplasmic 395, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:146015453-146015954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:146015955-146016454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146018867-146019815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146021109-146022007 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146022008-146022906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19712 Neighboring gene microRNA 6850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146024705-146025602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146025603-146026501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146026502-146027399 Neighboring gene ribosomal protein L8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28105 Neighboring gene zinc finger protein 517 Neighboring gene uncharacterized LOC100130027

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. genes encoding transcription factors expressed in the brain might be an important group of major depressive disorder candidate genes.
    Title: Novel variants in ZNF34 and other brain-expressed transcription factors are shared among early-onset MDD relatives.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC10520

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 34
Names
zinc finger protein 34 (KOX 32)
zinc finger protein KOX32

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286769.2 → NP_001273698.1  zinc finger protein 34 isoform 2

    See identical proteins and their annotated locations for NP_001273698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF235103, AL833814, W43004
    Consensus CDS
    CCDS69562.1
    UniProtKB/TrEMBL
    A0A0C4DG42
    Related
    ENSP00000396894.2, ENST00000429371.7
    Conserved Domains (3) summary
    smart00349
    Location:14 → 76
    KRAB; krueppel associated box
    COG5048
    Location:167 → 533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001286770.2 → NP_001273699.1  zinc finger protein 34 isoform 3

    See identical proteins and their annotated locations for NP_001273699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF235103, BP199961, W43004
    Conserved Domains (6) summary
    smart00349
    Location:35 → 101
    KRAB; krueppel associated box
    COG5048
    Location:148 → 514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:353 → 373
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:267 → 289
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:421 → 446
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001378027.1 → NP_001364956.1  zinc finger protein 34 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF235103
    Consensus CDS
    CCDS69562.1
    UniProtKB/TrEMBL
    A0A0C4DG42
    Related
    ENSP00000519634.1, ENST00000714367.1
    Conserved Domains (3) summary
    smart00349
    Location:14 → 76
    KRAB; krueppel associated box
    COG5048
    Location:167 → 533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001378028.1 → NP_001364957.1  zinc finger protein 34 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF235103
    Consensus CDS
    CCDS69562.1
    UniProtKB/TrEMBL
    A0A0C4DG42
    Related
    ENSP00000519630.1, ENST00000714363.1
    Conserved Domains (3) summary
    smart00349
    Location:14 → 76
    KRAB; krueppel associated box
    COG5048
    Location:167 → 533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001378029.1 → NP_001364958.1  zinc finger protein 34 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF235103
    UniProtKB/TrEMBL
    E9PNZ6, E9PSD0
    Related
    ENSP00000434049.2, ENST00000534337.7
    Conserved Domains (3) summary
    smart00349
    Location:14 → 80
    KRAB; krueppel associated box
    COG5048
    Location:127 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_030580.5 → NP_085057.3  zinc finger protein 34 isoform 1

    See identical proteins and their annotated locations for NP_085057.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF235103, BC004480, W43004
    Consensus CDS
    CCDS47945.1
    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0
    Conserved Domains (6) summary
    smart00349
    Location:35 → 97
    KRAB; krueppel associated box
    COG5048
    Location:188 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307 → 329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:461 → 486
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144772224..144787317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422270.1 → XP_047278226.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  2. XM_047422271.1 → XP_047278227.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  3. XM_047422274.1 → XP_047278230.1  zinc finger protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DG42
    Related
    ENSP00000635336.1, ENST00000965277.1

  4. XM_047422269.1 → XP_047278225.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  5. XM_047422272.1 → XP_047278228.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  6. XM_011517314.3 → XP_011515616.1  zinc finger protein 34 isoform X1

    See identical proteins and their annotated locations for XP_011515616.1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0
    Conserved Domains (6) summary
    smart00349
    Location:35 → 97
    KRAB; krueppel associated box
    COG5048
    Location:188 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307 → 329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:461 → 486
    zf-H2C2_2; Zinc-finger double domain

  7. XM_011517318.3 → XP_011515620.1  zinc finger protein 34 isoform X2

    See identical proteins and their annotated locations for XP_011515620.1

    UniProtKB/TrEMBL
    A0A0C4DG42
    Conserved Domains (3) summary
    smart00349
    Location:14 → 76
    KRAB; krueppel associated box
    COG5048
    Location:167 → 533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_047422273.1 → XP_047278229.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  9. XM_047422275.1 → XP_047278231.1  zinc finger protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DG42
    Related
    ENSP00000635342.1, ENST00000965283.1

  10. XM_047422276.1 → XP_047278232.1  zinc finger protein 34 isoform X3

  11. XM_017013874.2 → XP_016869363.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0
    Conserved Domains (6) summary
    smart00349
    Location:35 → 97
    KRAB; krueppel associated box
    COG5048
    Location:188 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307 → 329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:461 → 486
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145945720..145960823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361294.1 → XP_054217269.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  2. XM_054361295.1 → XP_054217270.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  3. XM_054361297.1 → XP_054217272.1  zinc finger protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DG42

  4. XM_054361298.1 → XP_054217273.1  zinc finger protein 34 isoform X3

  5. XM_054361296.1 → XP_054217271.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZ26.3 GenPept UniProtKB/Swiss-Prot:Q8IZ26

Gene LinkOut

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