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CYB5B cytochrome b5 type B [ Homo sapiens (human) ]

Gene ID: 80777, updated on 1-Mar-2024

Summary

Official Symbol
CYB5Bprovided by HGNC
Official Full Name
cytochrome b5 type Bprovided by HGNC
Primary source
HGNC:HGNC:24374
See related
Ensembl:ENSG00000103018 MIM:611964; AllianceGenome:HGNC:24374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OMB5; CYB5-M; CYPB5M
Summary
Enables heme binding activity. Contributes to nitrite reductase (NO-forming) activity. Involved in nitric oxide biosynthetic process. Located in membrane. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 70.4), colon (RPKM 17.6) and 22 other tissues See more
Orthologs
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Genomic context

See CYB5B in Genome Data Viewer
Location:
16q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (69424619..69466264)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (75226795..75268458)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69458522..69500167)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak2627 silencer Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69405429-69405928 Neighboring gene telomeric repeat binding factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69457805-69458352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69458353-69458900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7661 Neighboring gene transmembrane protein 111 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:69477408-69477690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11039 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:69488879-69489096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11041 Neighboring gene uncharacterized LOC105371325 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:69556814-69558013 Neighboring gene Sharpr-MPRA regulatory region 4304 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:69563811-69565010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69597937-69598833 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:69599594-69599770 Neighboring gene microRNA 1538

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein cytochrome b5 type B (CYB5B) in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp686M0619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to nitrite reductase (NO-forming) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane HDA PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
part_of nitric-oxide synthase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome b5 type B
Names
cytochrome b5 type B (outer mitochondrial membrane)
outer mitochondrial membrane cytochrome b5
type 2 cyt-b5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030579.3NP_085056.2  cytochrome b5 type B

    See identical proteins and their annotated locations for NP_085056.2

    Status: VALIDATED

    Source sequence(s)
    AC009032, AC026464
    Consensus CDS
    CCDS10880.2
    UniProtKB/Swiss-Prot
    A8K6B1, J3KNF8, O43169, Q96CC3, Q9BT35
    UniProtKB/TrEMBL
    H3BUX2
    Related
    ENSP00000308430.8, ENST00000307892.13
    Conserved Domains (2) summary
    cl00200
    Location:123148
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    pfam00173
    Location:28100
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    69424619..69466264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    75226795..75268458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)