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CYB5B cytochrome b5 type B [ Homo sapiens (human) ]

Gene ID: 80777, updated on 10-Oct-2020

Summary

Official Symbol
CYB5Bprovided by HGNC
Official Full Name
cytochrome b5 type Bprovided by HGNC
Primary source
HGNC:HGNC:24374
See related
Ensembl:ENSG00000103018 MIM:611964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OMB5; CYB5-M; CYPB5M
Expression
Ubiquitous expression in adrenal (RPKM 70.4), colon (RPKM 17.6) and 22 other tissues See more
Orthologs

Genomic context

See CYB5B in Genome Data Viewer
Location:
16q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (69424619..69466264)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69458498..69500167)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene telomeric repeat binding factor 2 Neighboring gene transmembrane protein 111 pseudogene Neighboring gene uncharacterized LOC105371325 Neighboring gene Sharpr-MPRA regulatory region 2580

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
GeneReviews: Not available
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein cytochrome b5 type B (CYB5B) in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686M0619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytochrome b5 type B
Names
cytochrome b5 type B (outer mitochondrial membrane)
outer mitochondrial membrane cytochrome b5
type 2 cyt-b5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030579.3NP_085056.2  cytochrome b5 type B

    See identical proteins and their annotated locations for NP_085056.2

    Status: VALIDATED

    Source sequence(s)
    AC009032, AC026464
    Consensus CDS
    CCDS10880.2
    UniProtKB/Swiss-Prot
    O43169
    UniProtKB/TrEMBL
    J3KNF8
    Related
    ENSP00000308430.8, ENST00000307892.13
    Conserved Domains (2) summary
    cl00200
    Location:123148
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    pfam00173
    Location:28100
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    69424619..69466264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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