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CPTP ceramide-1-phosphate transfer protein [ Homo sapiens (human) ]

Gene ID: 80772, updated on 28-Aug-2022

Summary

Official Symbol
CPTPprovided by HGNC
Official Full Name
ceramide-1-phosphate transfer proteinprovided by HGNC
Primary source
HGNC:HGNC:28116
See related
Ensembl:ENSG00000224051 MIM:615467; AllianceGenome:HGNC:28116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLTPD1
Summary
Enables ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Involved in several processes, including ceramide 1-phosphate transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of interleukin-1 beta production. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 11.0), colon (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

See CPTP in Genome Data Viewer
Location:
1p36.33
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1324802..1328896)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (756387..760481)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1260182..1264276)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase like 1 Neighboring gene integrator complex subunit 11 Neighboring gene microRNA 6727 Neighboring gene taste 1 receptor member 3 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene microRNA 6808

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC10334

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ceramide 1-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ceramide 1-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ceramide 1-phosphate transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ceramide 1-phosphate transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ceramide 1-phosphate transfer activity TAS
Traceable Author Statement
more info
 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ceramide-1-phosphate transfer protein
Names
GLTP domain-containing protein 1
glycolipid transfer protein domain containing 1
glycolipid transfer protein domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029885.2NP_001025056.1  ceramide-1-phosphate transfer protein

    See identical proteins and their annotated locations for NP_001025056.1

    Status: VALIDATED

    Source sequence(s)
    AL139287
    Consensus CDS
    CCDS30555.1
    UniProtKB/Swiss-Prot
    Q5TA50, Q7L5A4
    UniProtKB/TrEMBL
    S4S694
    Related
    ENSP00000343890.4, ENST00000343938.9
    Conserved Domains (1) summary
    pfam08718
    Location:30177
    GLTP; Glycolipid transfer protein (GLTP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1324802..1328896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542200.3XP_011540502.1  ceramide-1-phosphate transfer protein isoform X1

    See identical proteins and their annotated locations for XP_011540502.1

    UniProtKB/Swiss-Prot
    Q5TA50, Q7L5A4
    UniProtKB/TrEMBL
    S4S694
    Conserved Domains (1) summary
    pfam08718
    Location:30177
    GLTP; Glycolipid transfer protein (GLTP)
  2. XM_005244801.5XP_005244858.1  ceramide-1-phosphate transfer protein isoform X1

    See identical proteins and their annotated locations for XP_005244858.1

    UniProtKB/Swiss-Prot
    Q5TA50, Q7L5A4
    UniProtKB/TrEMBL
    S4S694
    Conserved Domains (1) summary
    pfam08718
    Location:30177
    GLTP; Glycolipid transfer protein (GLTP)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    756387..760481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)