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STARD5 StAR related lipid transfer domain containing 5 [ Homo sapiens (human) ]

Gene ID: 80765, updated on 23-Nov-2021


Official Symbol
STARD5provided by HGNC
Official Full Name
StAR related lipid transfer domain containing 5provided by HGNC
Primary source
See related
Ensembl:ENSG00000172345 MIM:607050
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a cholesterol transporter and is also able to bind and transport other sterol-derived molecules related to the cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016]
Ubiquitous expression in skin (RPKM 22.1), spleen (RPKM 14.8) and 23 other tissues See more
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Genomic context

See STARD5 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (81309053..81324141, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (81601394..81616482, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene talin rod domain containing 1 Neighboring gene cilia and flagella associated protein 161 Neighboring gene acidic nuclear phosphoprotein 32 family member B pseudogene 3 Neighboring gene interleukin 16 Neighboring gene TMC3 antisense RNA 1 Neighboring gene transmembrane channel like 3 Neighboring gene uncharacterized LOC102723985

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC10327

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bile acid binding IEA
Inferred from Electronic Annotation
more info
enables cholesterol binding IDA
Inferred from Direct Assay
more info
enables cholesterol transfer activity IDA
Inferred from Direct Assay
more info
Process Evidence Code Pubs
involved_in cholesterol import IDA
Inferred from Direct Assay
more info
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info

General protein information

Preferred Names
stAR-related lipid transfer protein 5
START domain containing 5
START domain-containing protein 5
StAR-related lipid transfer (START) domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181900.3NP_871629.1  stAR-related lipid transfer protein 5

    See identical proteins and their annotated locations for NP_871629.1

    Status: VALIDATED

    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC103858, AK026352, AK097024, AL137657, BC004365
    Consensus CDS
    ENSP00000304032.6, ENST00000302824.7
    Conserved Domains (1) summary
    START_STARD5-like; Lipid-binding START domain of mammalian STARD5 and related proteins


  1. NR_135013.2 RNA Sequence

    Status: VALIDATED

    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC103858, AK026352, AK097024

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    81309053..81324141 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030574.2: Suppressed sequence

    NM_030574.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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