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THAP7 THAP domain containing 7 [ Homo sapiens (human) ]

Gene ID: 80764, updated on 23-Nov-2021

Summary

Official Symbol
THAP7provided by HGNC
Official Full Name
THAP domain containing 7provided by HGNC
Primary source
HGNC:HGNC:23190
See related
Ensembl:ENSG00000184436 MIM:609518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 11.7), ovary (RPKM 8.9) and 25 other tissues See more
Orthologs
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Genomic context

See THAP7 in Genome Data Viewer
Location:
22q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20999104..21002118, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21353393..21356407, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene apoptosis inducing factor mitochondria associated 3 Neighboring gene Sharpr-MPRA regulatory region 818 Neighboring gene leucine zipper like transcription regulator 1 Neighboring gene THAP7 antisense RNA 1 Neighboring gene tubulin alpha 3f pseudogene Neighboring gene purinergic receptor P2X 6 Neighboring gene solute carrier family 7 member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables general transcription initiation factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleosomal histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphorylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
THAP domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008695.1NP_001008695.1  THAP domain-containing protein 7

    See identical proteins and their annotated locations for NP_001008695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC004346, BE264280, BM790105
    Consensus CDS
    CCDS13787.1
    UniProtKB/Swiss-Prot
    Q9BT49
    Related
    ENSP00000382084.2, ENST00000399133.2
    Conserved Domains (1) summary
    smart00980
    Location:493
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  2. NM_030573.3NP_085050.2  THAP domain-containing protein 7

    See identical proteins and their annotated locations for NP_085050.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC002470, AC002472, BC004346, BE264280, BM790105
    Consensus CDS
    CCDS13787.1
    UniProtKB/Swiss-Prot
    Q9BT49
    Related
    ENSP00000215742.4, ENST00000215742.9
    Conserved Domains (1) summary
    smart00980
    Location:493
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20999104..21002118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008696.1: Suppressed sequence

    Description
    NM_001008696.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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