Format

Send to:

Choose Destination

THAP7 THAP domain containing 7 [ Homo sapiens (human) ]

Gene ID: 80764, updated on 21-Dec-2019

Summary

Official Symbol
THAP7provided by HGNC
Official Full Name
THAP domain containing 7provided by HGNC
Primary source
HGNC:HGNC:23190
See related
Ensembl:ENSG00000184436 MIM:609518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 11.7), ovary (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See THAP7 in Genome Data Viewer
Location:
22q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20999104..21002118, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21354061..21356404, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene apoptosis inducing factor mitochondria associated 3 Neighboring gene Sharpr-MPRA regulatory region 818 Neighboring gene leucine zipper like transcription regulator 1 Neighboring gene THAP7 antisense RNA 1 Neighboring gene tubulin alpha 3f pseudogene Neighboring gene purinergic receptor P2X 6 Neighboring gene solute carrier family 7 member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C2H2 zinc finger domain binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
THAP domain-containing protein 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008695.1NP_001008695.1  THAP domain-containing protein 7

    See identical proteins and their annotated locations for NP_001008695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC004346, BE264280, BM790105
    Consensus CDS
    CCDS13787.1
    UniProtKB/Swiss-Prot
    Q9BT49
    Related
    ENSP00000382084.2, ENST00000399133.2
    Conserved Domains (1) summary
    smart00980
    Location:493
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
  2. NM_030573.3NP_085050.2  THAP domain-containing protein 7

    See identical proteins and their annotated locations for NP_085050.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC002470, AC002472, BC004346, BE264280, BM790105
    Consensus CDS
    CCDS13787.1
    UniProtKB/Swiss-Prot
    Q9BT49
    Related
    ENSP00000215742.4, ENST00000215742.9
    Conserved Domains (1) summary
    smart00980
    Location:493
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20999104..21002118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008696.1: Suppressed sequence

    Description
    NM_001008696.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center