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SPX spexin hormone [ Homo sapiens (human) ]

Gene ID: 80763, updated on 19-Jul-2021

Summary

Official Symbol
SPXprovided by HGNC
Official Full Name
spexin hormoneprovided by HGNC
Primary source
HGNC:HGNC:28139
See related
Ensembl:ENSG00000134548 MIM:619246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf39
Summary
The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Biased expression in fat (RPKM 72.3), thyroid (RPKM 9.5) and 4 other tissues See more
Orthologs
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Genomic context

See SPX in Genome Data Viewer
Location:
12p12.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (21526296..21532947)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21679230..21685881)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31 Neighboring gene RecQ like helicase Neighboring gene golgi transport 1B Neighboring gene glycogen synthase 2 Neighboring gene uncharacterized LOC105369689 Neighboring gene lactate dehydrogenase B Neighboring gene uncharacterized LOC102724261

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10946

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide hormone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of renal sodium excretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gastro-intestinal system smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of gastro-intestinal system smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of systemic arterial blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
spexin
Names
NPQ
neuropeptide Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030572.4NP_085049.1  spexin precursor

    See identical proteins and their annotated locations for NP_085049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC006559, AK075342, CR742701, DA380664, DB159488
    Consensus CDS
    CCDS31757.1
    UniProtKB/Swiss-Prot
    Q9BT56
    Related
    ENSP00000256969.2, ENST00000256969.7
    Conserved Domains (1) summary
    pfam15171
    Location:27116
    Spexin; Neuropeptide secretory protein family, NPQ, spexin

RNA

  1. NR_135187.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC006559, AK075342, CR742701, DA260291, DB159488
  2. NR_135188.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC006559, AK075342, CR742701, DA071522, DB159488

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    21526296..21532947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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