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Rnf34 ring finger protein 34 [ Mus musculus (house mouse) ]

Gene ID: 80751, updated on 26-Sep-2022

Summary

Official Symbol
Rnf34provided by MGI
Official Full Name
ring finger protein 34provided by MGI
Primary source
MGI:MGI:2153340
See related
Ensembl:ENSMUSG00000029474 AllianceGenome:MGI:2153340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIFF
Summary
Predicted to enable several functions, including p53 binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Involved in cellular response to cold; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of oxygen metabolic process. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; and sensory organ. Orthologous to human RNF34 (ring finger protein 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.5), testis adult (RPKM 20.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf34 in Genome Data Viewer
Location:
5; 5 F
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122988175..123007008)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122850112..122868945)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene anaphase-promoting complex subunit 5 Neighboring gene predicted gene, 33044 Neighboring gene lysine (K)-specific demethylase 2B Neighboring gene predicted gene, 33118 Neighboring gene RIKEN cDNA A930024E05 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Markers

Homology

Clone Names

  • MGC7670

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of oxygen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF34
Names
RING finger protein RIFF
RING-type E3 ubiquitin transferase RNF34
phafin 1
NP_085041.1
XP_006530575.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030564.1NP_085041.1  E3 ubiquitin-protein ligase RNF34

    See identical proteins and their annotated locations for NP_085041.1

    Status: PROVISIONAL

    Source sequence(s)
    BC004042
    Consensus CDS
    CCDS19656.1
    UniProtKB/Swiss-Prot
    Q3UV45, Q99KR6
    Related
    ENSMUSP00000031434.7, ENSMUST00000031434.8
    Conserved Domains (2) summary
    cd15769
    Location:59105
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    pfam13920
    Location:325367
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122988175..123007008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530512.2XP_006530575.1  E3 ubiquitin-protein ligase RNF34 isoform X1

    Conserved Domains (2) summary
    cd16706
    Location:255293
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins
    cl28890
    Location:232
    FYVE_like_SF; FYVE domain like superfamily