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N4bp1 NEDD4 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 80750, updated on 8-Feb-2024

Summary

Official Symbol
N4bp1provided by MGI
Official Full Name
NEDD4 binding protein 1provided by MGI
Primary source
MGI:MGI:2136825
See related
Ensembl:ENSMUSG00000031652 AllianceGenome:MGI:2136825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mRNA binding activity; ribonuclease activity; and ubiquitin binding activity. Involved in cellular response to UV; negative regulation of macromolecule metabolic process; and regulation of innate immune response. Located in PML body; cytosol; and nucleolus. Orthologous to human N4BP1 (NEDD4 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach adult (RPKM 8.2), duodenum adult (RPKM 8.2) and 28 other tissues See more
Orthologs
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Genomic context

See N4bp1 in Genome Data Viewer
Location:
8 C3; 8 42.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (87567764..87612489, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (86841136..86885296, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene siah E3 ubiquitin protein ligase 1A Neighboring gene STARR-seq mESC enhancer starr_22187 Neighboring gene predicted gene 10638 Neighboring gene STARR-seq mESC enhancer starr_22189 Neighboring gene predicted gene, 39215 Neighboring gene predicted gene, 33877 Neighboring gene STARR-positive B cell enhancer ABC_E11393 Neighboring gene STARR-seq mESC enhancer starr_22192 Neighboring gene STARR-seq mESC enhancer starr_22193 Neighboring gene ferritin heavy chain, pseudogene 3 Neighboring gene predicted gene, 33391

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC7607

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030563.2NP_085040.2  NEDD4-binding protein 1

    See identical proteins and their annotated locations for NP_085040.2

    Status: VALIDATED

    Source sequence(s)
    AA444325, AK147522, BC089324, BM951093, CJ134294, CX122841, CX240926
    Consensus CDS
    CCDS52625.1
    UniProtKB/Swiss-Prot
    Q3TCI4, Q3UH87, Q3UY69, Q6A037
    Related
    ENSMUSP00000034074.8, ENSMUST00000034074.8
    Conserved Domains (1) summary
    pfam11977
    Location:614767
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    87567764..87612489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531517.4XP_006531580.1  NEDD4-binding protein 1 isoform X3

  2. XM_006531516.4XP_006531579.1  NEDD4-binding protein 1 isoform X1

    Conserved Domains (1) summary
    cl20439
    Location:628691
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  3. XM_036154392.1XP_036010285.1  NEDD4-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q5EBQ4
    Conserved Domains (2) summary
    cd18728
    Location:532658
    PIN_N4BP1-like; PRORP-like PIN domain of NEDD4 binding protein 1 and related proteins
    cl00098
    Location:156
    KH-I; K homology (KH) RNA-binding domain, type I
  4. XM_036154391.1XP_036010284.1  NEDD4-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q5EBQ4
    Conserved Domains (2) summary
    cd18728
    Location:532658
    PIN_N4BP1-like; PRORP-like PIN domain of NEDD4 binding protein 1 and related proteins
    cl00098
    Location:156
    KH-I; K homology (KH) RNA-binding domain, type I
  5. XM_036154393.1XP_036010286.1  NEDD4-binding protein 1 isoform X4

    Conserved Domains (1) summary
    cl00098
    Location:156
    KH-I; K homology (KH) RNA-binding domain, type I

RNA

  1. XR_004934903.1 RNA Sequence