Car15 carbonic anhydrase 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Car15provided by MGI
Official Full Name: carbonic anhydrase 15provided by MGI
Primary source: MGI:MGI:1931324
See related: Ensembl:ENSMUSG00000090236 AllianceGenome:MGI:1931324
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ca15; Cals2
Summary: Enables carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Located in membrane. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 108.7) and cerebellum adult (RPKM 8.7) See more
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Genomic context

Location:: 16 A3; 16 11.05 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17653140..17656050, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (17835276..17838186, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland.
Title: Carbonic anhydrases in the mouse harderian gland.
CA XV is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney and may have a role in the regulation of acid-base homeostasis
Title: The most recently discovered carbonic anhydrase, CA XV, is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney.
cloning & purification of CA XV; the enzyme shows a moderate catalytic activity for the physiologic reaction, similarly to the physiologically relevant isoforms CA I, IV, VI, XII, and XIV, and it is susceptible to inhibition by sulfonamides and sulfamates
Title: Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Mouse carbonic anhydrase XV, absent in humans, is a moderately active enzyme which may play a physiological role at least in the kidney. [review]
Title: Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV.
CA XV is the first member of the alpha-CA gene family that is expressed in several species, but not in humans and chimpanzees.
Title: Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase.

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General gene information

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Markers

AI315043 (e-PCR)
- UniSTS:165982

NoName (e-PCR)
- UniSTS:237451

Car15 (e-PCR), detects polymorphism
- UniSTS:506770

Homology

Homologs of the Car15 gene: The Car15 gene is conserved in dog, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables carbonate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carbonic anhydrase 15

Names: CA-XV; carbonate dehydratase XV; carbonic anhydrase XV; carbonic anhydrase-like sequence 2

NP_085035.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030558.2 → NP_085035.1 carbonic anhydrase 15 precursor

See identical proteins and their annotated locations for NP_085035.1

Status: PROVISIONAL

Source sequence(s)

BC019975

Consensus CDS

CCDS49784.1

UniProtKB/Swiss-Prot

Q99N23

Related

ENSMUSP00000113400.2, ENSMUST00000118960.2

Conserved Domains (1) summary

cd03117
Location:48 → 291

alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...