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SRCIN1 SRC kinase signaling inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 80725, updated on 1-Jun-2020

Summary

Official Symbol
SRCIN1provided by HGNC
Official Full Name
SRC kinase signaling inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:29506
See related
Ensembl:ENSG00000277363 MIM:610786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P140; SNIP
Expression
Biased expression in brain (RPKM 9.1), salivary gland (RPKM 1.2) and 2 other tissues See more
Orthologs

Genomic context

See SRCIN1 in Genome Data Viewer
Location:
17q12
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (38530015..38607166, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36686259..36762183, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 681 Neighboring gene Rho GTPase activating protein 23 Neighboring gene uncharacterized LOC101929494 Neighboring gene uncharacterized LOC105371761 Neighboring gene Sharpr-MPRA regulatory region 2012 Neighboring gene elongin BC and polycomb repressive complex 2 associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1684

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
NOT focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SRC kinase signaling inhibitor 1
Names
P130Cas-associated protein
SNAP-25-interacting protein
SNAP25-interacting protein
p140Cap

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025248.3NP_079524.2  SRC kinase signaling inhibitor 1

    See identical proteins and their annotated locations for NP_079524.2

    Status: VALIDATED

    Source sequence(s)
    AC006449, AC115090, AC129916
    Consensus CDS
    CCDS45660.1
    UniProtKB/Swiss-Prot
    Q9C0H9
    Related
    ENSP00000484715.1, ENST00000617146.5
    Conserved Domains (2) summary
    cl25732
    Location:686840
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27222
    Location:184263
    AIP3; Actin interacting protein 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    38530015..38607166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025169.1XP_016880658.1  SRC kinase signaling inhibitor 1 isoform X1

  2. XM_017025172.1XP_016880661.1  SRC kinase signaling inhibitor 1 isoform X4

  3. XM_017025171.1XP_016880660.1  SRC kinase signaling inhibitor 1 isoform X3

  4. XM_017025170.1XP_016880659.1  SRC kinase signaling inhibitor 1 isoform X2

  5. XM_017025173.1XP_016880662.1  SRC kinase signaling inhibitor 1 isoform X5

  6. XM_017025174.1XP_016880663.1  SRC kinase signaling inhibitor 1 isoform X6

    Related
    ENST00000621763.4

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2565332..2641271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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