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SRCIN1 SRC kinase signaling inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 80725, updated on 17-Jun-2024

Summary

Official Symbol
SRCIN1provided by HGNC
Official Full Name
SRC kinase signaling inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:29506
See related
Ensembl:ENSG00000277363 MIM:610786; AllianceGenome:HGNC:29506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P140; SNIP
Summary
Enables protein kinase binding activity. Involved in several processes, including regulation of dendritic spine morphogenesis; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 9.1), salivary gland (RPKM 1.2) and 2 other tissues See more
Orthologs
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Genomic context

See SRCIN1 in Genome Data Viewer
Location:
17q12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38530031..38607025, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39393085..39470208, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36686266..36762205, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 7 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36570079-36571013 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:36571014-36571949 and GRCh37_chr17:36571950-36572884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36574173-36574722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36574723-36575272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36575776-36576704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36577634-36578562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36580149-36580794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36584872-36585780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36585781-36586688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36592213-36592713 Neighboring gene Rho GTPase activating protein 23 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36597014-36597516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36605280-36606221 Neighboring gene uncharacterized LOC101929494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36607163-36608104 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:36614287-36614452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36616590-36617218 Neighboring gene Sharpr-MPRA regulatory region 7659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36621073-36621864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36625516-36626152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36628374-36628874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36640731-36641252 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36649489-36649990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36649991-36650490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36655308-36655834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36655835-36656359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36665002-36665819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36665820-36666636 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:36706969-36707178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36717306-36717859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36718413-36718965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36718966-36719517 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36719518-36720070 Neighboring gene uncharacterized LOC105371761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36720624-36721176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36721177-36721728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36722271-36722779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36734639-36735366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36735367-36736094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36748159-36748740 Neighboring gene uncharacterized LOC124903992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36749033-36749534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36749535-36750034 Neighboring gene Sharpr-MPRA regulatory region 8854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36763065-36763666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36763667-36764267 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36765411-36766081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36775868-36776378 Neighboring gene Sharpr-MPRA regulatory region 2012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36814959-36815458 Neighboring gene Sharpr-MPRA regulatory region 11404 Neighboring gene Sharpr-MPRA regulatory region 8107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36829618-36830453 Neighboring gene Sharpr-MPRA regulatory region 4536 Neighboring gene uncharacterized LOC105371763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36858367-36858898 Neighboring gene elongin BC and polycomb repressive complex 2 associated protein Neighboring gene microRNA 4734

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1684

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SRC kinase signaling inhibitor 1
Names
P130Cas-associated protein
SNAP-25-interacting protein
SNAP25-interacting protein
p140Cap

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025248.3NP_079524.2  SRC kinase signaling inhibitor 1

    See identical proteins and their annotated locations for NP_079524.2

    Status: VALIDATED

    Source sequence(s)
    AC006449, AC115090, AC129916
    Consensus CDS
    CCDS45660.1
    UniProtKB/Swiss-Prot
    Q75T46, Q8N4W8, Q9C0H9
    UniProtKB/TrEMBL
    A0A087X165
    Related
    ENSP00000484715.1, ENST00000617146.5
    Conserved Domains (2) summary
    cl25732
    Location:686840
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27222
    Location:184263
    AIP3; Actin interacting protein 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38530031..38607025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025169.2XP_016880658.1  SRC kinase signaling inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A087X165
  2. XM_017025172.2XP_016880661.1  SRC kinase signaling inhibitor 1 isoform X5

    UniProtKB/TrEMBL
    A0A087X165
  3. XM_017025171.2XP_016880660.1  SRC kinase signaling inhibitor 1 isoform X3

    UniProtKB/TrEMBL
    A0A087X165
  4. XM_017025170.2XP_016880659.1  SRC kinase signaling inhibitor 1 isoform X2

    UniProtKB/TrEMBL
    A0A087X165
  5. XM_047436852.1XP_047292808.1  SRC kinase signaling inhibitor 1 isoform X7

    UniProtKB/TrEMBL
    A0A087X165
  6. XM_017025173.2XP_016880662.1  SRC kinase signaling inhibitor 1 isoform X6

    UniProtKB/TrEMBL
    A0A087X165
  7. XM_047436851.1XP_047292807.1  SRC kinase signaling inhibitor 1 isoform X4

    UniProtKB/TrEMBL
    A0A087X165
    Related
    ENST00000621763.4

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2565325..2642452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329377.1XP_054185352.1  SRC kinase signaling inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A087X165
  2. XM_054329379.1XP_054185354.1  SRC kinase signaling inhibitor 1 isoform X3

    UniProtKB/TrEMBL
    A0A087X165
  3. XM_054329378.1XP_054185353.1  SRC kinase signaling inhibitor 1 isoform X2

    UniProtKB/TrEMBL
    A0A087X165
  4. XM_054329381.1XP_054185356.1  SRC kinase signaling inhibitor 1 isoform X5

    UniProtKB/TrEMBL
    A0A087X165
  5. XM_054329383.1XP_054185358.1  SRC kinase signaling inhibitor 1 isoform X7

    UniProtKB/TrEMBL
    A0A087X165
  6. XM_054329382.1XP_054185357.1  SRC kinase signaling inhibitor 1 isoform X6

    UniProtKB/TrEMBL
    A0A087X165
  7. XM_054329380.1XP_054185355.1  SRC kinase signaling inhibitor 1 isoform X4

    UniProtKB/TrEMBL
    A0A087X165

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    39393085..39470208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317415.1XP_054173390.1  SRC kinase signaling inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A087X165
  2. XM_054317417.1XP_054173392.1  SRC kinase signaling inhibitor 1 isoform X3

    UniProtKB/TrEMBL
    A0A087X165
  3. XM_054317416.1XP_054173391.1  SRC kinase signaling inhibitor 1 isoform X2

    UniProtKB/TrEMBL
    A0A087X165
  4. XM_054317419.1XP_054173394.1  SRC kinase signaling inhibitor 1 isoform X5

    UniProtKB/TrEMBL
    A0A087X165
  5. XM_054317421.1XP_054173396.1  SRC kinase signaling inhibitor 1 isoform X7

    UniProtKB/TrEMBL
    A0A087X165
  6. XM_054317420.1XP_054173395.1  SRC kinase signaling inhibitor 1 isoform X6

    UniProtKB/TrEMBL
    A0A087X165
  7. XM_054317418.1XP_054173393.1  SRC kinase signaling inhibitor 1 isoform X4

    UniProtKB/TrEMBL
    A0A087X165