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SRCIN1 SRC kinase signaling inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 80725, updated on 22-Sep-2022

Summary

Official Symbol
SRCIN1provided by HGNC
Official Full Name
SRC kinase signaling inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:29506
See related
Ensembl:ENSG00000277363 MIM:610786; AllianceGenome:HGNC:29506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P140; SNIP
Summary
Enables protein kinase binding activity. Involved in several processes, including regulation of dendritic spine morphogenesis; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 9.1), salivary gland (RPKM 1.2) and 2 other tissues See more
Orthologs
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Genomic context

See SRCIN1 in Genome Data Viewer
Location:
17q12
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38530031..38607025, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39393092..39469025, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36686266..36762205, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:36571014-36571949 and GRCh37_chr17:36571950-36572884 Neighboring gene Rho GTPase activating protein 23 Neighboring gene uncharacterized LOC101929494 Neighboring gene uncharacterized LOC105371761 Neighboring gene uncharacterized LOC124903992 Neighboring gene Sharpr-MPRA regulatory region 2012 Neighboring gene Sharpr-MPRA regulatory region 11404

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1684

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
NOT located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SRC kinase signaling inhibitor 1
Names
P130Cas-associated protein
SNAP-25-interacting protein
SNAP25-interacting protein
p140Cap

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025248.3NP_079524.2  SRC kinase signaling inhibitor 1

    See identical proteins and their annotated locations for NP_079524.2

    Status: VALIDATED

    Source sequence(s)
    AC006449, AC115090, AC129916
    Consensus CDS
    CCDS45660.1
    UniProtKB/Swiss-Prot
    Q8N4W8, Q9C0H9
    Related
    ENSP00000484715.1, ENST00000617146.5
    Conserved Domains (2) summary
    cl25732
    Location:686840
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27222
    Location:184263
    AIP3; Actin interacting protein 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38530031..38607025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025169.2XP_016880658.1  SRC kinase signaling inhibitor 1 isoform X1

  2. XM_017025172.2XP_016880661.1  SRC kinase signaling inhibitor 1 isoform X5

  3. XM_017025171.2XP_016880660.1  SRC kinase signaling inhibitor 1 isoform X3

  4. XM_017025170.2XP_016880659.1  SRC kinase signaling inhibitor 1 isoform X2

  5. XM_047436852.1XP_047292808.1  SRC kinase signaling inhibitor 1 isoform X7

  6. XM_017025173.2XP_016880662.1  SRC kinase signaling inhibitor 1 isoform X6

  7. XM_047436851.1XP_047292807.1  SRC kinase signaling inhibitor 1 isoform X4

    Related
    ENST00000621763.4

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2565332..2641271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    39393092..39469025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)