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UBXN6 UBX domain protein 6 [ Homo sapiens (human) ]

Gene ID: 80700, updated on 20-Sep-2020

Summary

Official Symbol
UBXN6provided by HGNC
Official Full Name
UBX domain protein 6provided by HGNC
Primary source
HGNC:HGNC:14928
See related
Ensembl:ENSG00000167671 MIM:611946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBXD1; UBXDC2
Expression
Ubiquitous expression in testis (RPKM 49.0), kidney (RPKM 36.6) and 25 other tissues See more
Orthologs

Genomic context

See UBXN6 in Genome Data Viewer
Location:
19p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4445006..4458759, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4445003..4457791, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 Neighboring gene Sharpr-MPRA regulatory regions 465 and 6457 Neighboring gene uncharacterized LOC107985297 Neighboring gene chromatin assembly factor 1 subunit A Neighboring gene microRNA 4746 Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00394, DKFZp667D109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome to lysosome transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UBX domain-containing protein 6
Names
CTB-50L17.16
UBX domain containing 1
UBX domain-containing 2
UBX domain-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171091.2NP_001164562.1  UBX domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001164562.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, resulting in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1 at the N-terminus.
    Source sequence(s)
    AC011498, AF272894, BC007414, BC008288
    Consensus CDS
    CCDS54201.1
    UniProtKB/Swiss-Prot
    Q9BZV1
    Related
    ENSP00000378246.2, ENST00000394765.7
    Conserved Domains (2) summary
    cd10460
    Location:105210
    PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
    cl00155
    Location:281354
    UBQ; Ubiquitin-like proteins
  2. NM_025241.3NP_079517.1  UBX domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_079517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC007414, BC008288, BM764980
    Consensus CDS
    CCDS12129.1
    UniProtKB/Swiss-Prot
    Q9BZV1
    Related
    ENSP00000301281.5, ENST00000301281.11
    Conserved Domains (3) summary
    cd10460
    Location:158263
    PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
    PHA00003
    Location:63103
    B; internal scaffolding protein
    cl00155
    Location:334407
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4445006..4458759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027325.1XP_016882814.1  UBX domain-containing protein 6 isoform X1

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