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FOSL1 FOS like 1, AP-1 transcription factor subunit [ Homo sapiens (human) ]

Gene ID: 8061, updated on 11-Jul-2021

Summary

Official Symbol
FOSL1provided by HGNC
Official Full Name
FOS like 1, AP-1 transcription factor subunitprovided by HGNC
Primary source
HGNC:HGNC:13718
See related
Ensembl:ENSG00000175592 MIM:136515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRA; FRA1; fra-1
Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Biased expression in gall bladder (RPKM 16.7), urinary bladder (RPKM 10.2) and 13 other tissues See more
Orthologs
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Genomic context

See FOSL1 in Genome Data Viewer
Location:
11q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65892049..65900545, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65659520..65668016, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cathepsin W Neighboring gene FGF1 intracellular binding protein Neighboring gene coiled-coil domain containing 85B Neighboring gene CRISPRi-validated cis-regulatory element chr11.3338 Neighboring gene NFE2L2 motif-containing MPRA enhancer 146/147

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to extracellular stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in learning IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in placenta blood vessel development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription, initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to cAMP IEA
Inferred from Electronic Annotation
more info
 
involved_in response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to drug IEA
Inferred from Electronic Annotation
more info
 
involved_in response to gravity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to progesterone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to virus TAS
Traceable Author Statement
more info
PubMed 
involved_in vitellogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fos-related antigen 1
Names
FOS like 1, AP-1 trancription factor subunit
FOS-like antigen-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300844.2NP_001287773.1  fos-related antigen 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA120824, AK299050, AP006287, BM764259, BQ937004
    Consensus CDS
    CCDS73324.1
    UniProtKB/Swiss-Prot
    P15407
    UniProtKB/TrEMBL
    E9PPX2
    Related
    ENSP00000436276.1, ENST00000531493.5
    Conserved Domains (2) summary
    cl21462
    Location:99132
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cl28929
    Location:98214
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
  2. NM_001300855.2NP_001287784.1  fos-related antigen 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA120824, AP006287, BC016648, BP222547, BQ937004
    Consensus CDS
    CCDS76437.1
    UniProtKB/Swiss-Prot
    P15407
    UniProtKB/TrEMBL
    E9PKL5
    Related
    ENSP00000431594.1, ENST00000532401.1
  3. NM_001300856.2NP_001287785.1  fos-related antigen 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA120824, AP006287, BC016648, BQ937004, CB123614
    UniProtKB/Swiss-Prot
    P15407
    Conserved Domains (2) summary
    PRK13729
    Location:63184
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd14721
    Location:49102
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
  4. NM_001300857.2NP_001287786.1  fos-related antigen 1 isoform 5

    See identical proteins and their annotated locations for NP_001287786.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA120824, AP006287, BC016648, BM846271, BQ937004
    Consensus CDS
    CCDS76436.1
    UniProtKB/Swiss-Prot
    P15407
    Related
    ENSP00000393302.2, ENST00000448083.6
    Conserved Domains (2) summary
    PRK13729
    Location:35148
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cl21462
    Location:3466
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  5. NM_005438.5NP_005429.1  fos-related antigen 1 isoform 1

    See identical proteins and their annotated locations for NP_005429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA120824, AP006287, BC016648, BQ937004
    Consensus CDS
    CCDS8121.1
    UniProtKB/Swiss-Prot
    P15407
    UniProtKB/TrEMBL
    A0A0S2Z595
    Related
    ENSP00000310170.2, ENST00000312562.7
    Conserved Domains (2) summary
    PRK13729
    Location:129250
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd14721
    Location:115168
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RNA

  1. NR_125339.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction at the 3' end of the first exon and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA120824, AP006287, BC016648, BQ937004

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65892049..65900545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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