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RASSF7 Ras association domain family member 7 [ Homo sapiens (human) ]

Gene ID: 8045, updated on 1-Jun-2020

Summary

Official Symbol
RASSF7provided by HGNC
Official Full Name
Ras association domain family member 7provided by HGNC
Primary source
HGNC:HGNC:1166
See related
Ensembl:ENSG00000099849 MIM:143023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRC1; FAP88; HRAS1; CFAP88; C11orf13
Expression
Broad expression in stomach (RPKM 14.8), colon (RPKM 12.6) and 23 other tissues See more
Orthologs

Genomic context

See RASSF7 in Genome Data Viewer
Location:
11p15.5
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (560970..564025)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (560309..564025)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 56 Neighboring gene collagen alpha-2(IV) chain-like Neighboring gene HRas proto-oncogene, GTPase Neighboring gene lamin tail domain containing 2 Neighboring gene LMNTD2 antisense RNA 1 Neighboring gene MIR210 host gene Neighboring gene microRNA 210 Neighboring gene uncharacterized LOC143666

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126069, MGC126070

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ras association domain-containing protein 7
Names
HRAS1-related cluster protein 1
HRAS1-related cluster-1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
Ras association (RalGDS/AF-6) domain family 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143993.2NP_001137465.1  ras association domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001137465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' UTR and 3' coding region, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL535761, AP006284, BC106921, CA315057
    Consensus CDS
    CCDS44506.1
    UniProtKB/Swiss-Prot
    Q02833
    Related
    ENSP00000380712.3, ENST00000397582.7
    Conserved Domains (1) summary
    smart00314
    Location:888
    RA; Ras association (RalGDS/AF-6) domain
  2. NM_001143994.2NP_001137466.1  ras association domain-containing protein 7 isoform 3

    See identical proteins and their annotated locations for NP_001137466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region, compared to variant 1. This difference results in a frameshift and a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP006284, BC106921, BC106922, CA315057
    Consensus CDS
    CCDS44505.1
    UniProtKB/Swiss-Prot
    Q02833
    Related
    ENSP00000405606.2, ENST00000454668.2
    Conserved Domains (1) summary
    smart00314
    Location:888
    RA; Ras association (RalGDS/AF-6) domain
  3. NM_003475.4NP_003466.1  ras association domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_003466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AP006284, BC106921, CA315057
    Consensus CDS
    CCDS7702.1
    UniProtKB/Swiss-Prot
    Q02833
    UniProtKB/TrEMBL
    A0A024RCE4
    Related
    ENSP00000380713.3, ENST00000397583.8
    Conserved Domains (3) summary
    pfam00788
    Location:886
    RA; Ras association (RalGDS/AF-6) domain
    cl25363
    Location:123199
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
    cl25732
    Location:177294
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    560970..564025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    90626..93681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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