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CD276 CD276 molecule [ Homo sapiens (human) ]

Gene ID: 80381, updated on 4-Jun-2023

Summary

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Official Symbol
CD276provided by HGNC
Official Full Name
CD276 moleculeprovided by HGNC
Primary source
HGNC:HGNC:19137
See related
Ensembl:ENSG00000103855 MIM:605715; AllianceGenome:HGNC:19137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
Summary
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues See more
Orthologs
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Genomic context

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See CD276 in Genome Data Viewer
Location:
15q24.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (73683944..73714514)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (71501041..71531847)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73976724..74006855)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:73975613-73976121 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:73977139-73977645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:73988434-73988945 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr15:73988946-73989458 and GRCh37_chr15:73989459-73989969 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:73994347-73995068 Neighboring gene inhibitory synaptic factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74043809-74044582 Neighboring gene INSYN1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. B7-H3 immunoregulatory roles in cancer. Mortezaee K. Biomed Pharmacother, 2023 Jul. PMID 37196544
  2. Immunohistochemical analysis of B7-H3 expression in patients with lung cancer following various anti-cancer treatments. Omori S, et al. Invest New Drugs, 2023 Apr. PMID 37036580
  3. Evaluation of serum B7-H3 expression, ultrasound and clinical characteristics to predict the risk of cervical lymph node metastases in papillary thyroid carcinoma by nomogram. Huang Y, et al. J Clin Lab Anal, 2023 Jan. PMID 36525343, Free PMC Article
  4. Comprehensive analysis of alternative polyadenylation regulators concerning CD276 and immune infiltration in bladder cancer. Xiong M, et al. BMC Cancer, 2022 Sep 29. PMID 36175880, Free PMC Article
  5. Elevated Expression of the Immune Checkpoint Ligand CD276 (B7-H3) in Urothelial Carcinoma Cell Lines Correlates Negatively with the Cell Proliferation. Harland N, et al. Int J Mol Sci, 2022 Apr 29. PMID 35563359, Free PMC Article

See all (214) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B7-H3 immunoregulatory roles in cancer.
    Title: B7-H3 immunoregulatory roles in cancer.
  2. Immunohistochemical analysis of B7-H3 expression in patients with lung cancer following various anti-cancer treatments.
    Title: Immunohistochemical analysis of B7-H3 expression in patients with lung cancer following various anti-cancer treatments.
  3. Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cellsdagger.
    Title: Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cells†.
  4. Evaluation of serum B7-H3 expression, ultrasound and clinical characteristics to predict the risk of cervical lymph node metastases in papillary thyroid carcinoma by nomogram.
    Title: Evaluation of serum B7-H3 expression, ultrasound and clinical characteristics to predict the risk of cervical lymph node metastases in papillary thyroid carcinoma by nomogram.
  5. Comprehensive analysis of alternative polyadenylation regulators concerning CD276 and immune infiltration in bladder cancer.
    Title: Comprehensive analysis of alternative polyadenylation regulators concerning CD276 and immune infiltration in bladder cancer.
  6. Clinical significance of B7-H3 and HER2 co-expression and therapeutic value of combination treatment in gastric cancer.
    Title: Clinical significance of B7-H3 and HER2 co-expression and therapeutic value of combination treatment in gastric cancer.
  7. Association of B7-H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancer.
    Title: Association of B7-H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancer.
  8. Elevated Expression of the Immune Checkpoint Ligand CD276 (B7-H3) in Urothelial Carcinoma Cell Lines Correlates Negatively with the Cell Proliferation.
    Title: Elevated Expression of the Immune Checkpoint Ligand CD276 (B7-H3) in Urothelial Carcinoma Cell Lines Correlates Negatively with the Cell Proliferation.
  9. B7 homolog 3 induces lung metastasis of breast cancer through Raf/MEK/ERK axis.
    Title: B7 homolog 3 induces lung metastasis of breast cancer through Raf/MEK/ERK axis.
  10. B7-H3 blockade decreases macrophage inflammatory response and alleviates clinical symptoms of arthritis.
    Title: B7-H3 blockade decreases macrophage inflammatory response and alleviates clinical symptoms of arthritis.
Submit: New GeneRIF Correction See all GeneRIFs (188)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.
EBI GWAS Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables signaling receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of immune response NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in external side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
CD276 antigen
Names
B7 homolog 3
costimulatory molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051242.1 RefSeqGene

    Range
    5418..35549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024736.2 → NP_001019907.1  CD276 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_001019907.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK075549, BC062581, CA420873
    Consensus CDS
    CCDS32288.1
    UniProtKB/Swiss-Prot
    Q5ZPR3, Q9BXR1
    Related
    ENSP00000320084.5, ENST00000318443.10
    Conserved Domains (2) summary
    smart00410
    Location:156 → 237
    IG_like; Immunoglobulin like
    cl11960
    Location:261 → 357
    Ig; Immunoglobulin domain

  2. NM_001329628.2 → NP_001316557.1  CD276 antigen isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC022188, AC100838, CA420873
    Consensus CDS
    CCDS10251.1
    UniProtKB/Swiss-Prot
    Q5ZPR3

  3. NM_001329629.2 → NP_001316558.1  CD276 antigen isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform a.
    Source sequence(s)
    AK292711, BC011578, BC062581, CA420873
    Consensus CDS
    CCDS86475.1
    UniProtKB/Swiss-Prot
    Q5ZPR3
    UniProtKB/TrEMBL
    A0A0C4DGH0, A8K9J6
    Related
    ENSP00000441087.2, ENST00000537340.6
    Conserved Domains (2) summary
    smart00410
    Location:10 → 91
    IG_like; Immunoglobulin like
    cl11960
    Location:115 → 211
    Ig; Immunoglobulin domain

  4. NM_025240.3 → NP_079516.1  CD276 antigen isoform b precursor

    See identical proteins and their annotated locations for NP_079516.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AF302102, AK075549, BC062581, CA420873
    Consensus CDS
    CCDS10251.1
    UniProtKB/Swiss-Prot
    Q5ZPR3
    Related
    ENSP00000320058.5, ENST00000318424.9
    Conserved Domains (2) summary
    smart00410
    Location:156 → 238
    IG_like; Immunoglobulin like
    cl11960
    Location:43 → 139
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    73683944..73714514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022638.2 → XP_016878127.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q5ZPR3, Q9BXR1
    Conserved Domains (2) summary
    smart00410
    Location:156 → 237
    IG_like; Immunoglobulin like
    cl11960
    Location:261 → 357
    Ig; Immunoglobulin domain

  2. XM_011522095.3 → XP_011520397.1  CD276 antigen isoform X1

    See identical proteins and their annotated locations for XP_011520397.1

    UniProtKB/Swiss-Prot
    Q5ZPR3, Q9BXR1
    Conserved Domains (2) summary
    smart00410
    Location:156 → 237
    IG_like; Immunoglobulin like
    cl11960
    Location:261 → 357
    Ig; Immunoglobulin domain

  3. XM_005254700.5 → XP_005254757.1  CD276 antigen isoform X1

    See identical proteins and their annotated locations for XP_005254757.1

    UniProtKB/Swiss-Prot
    Q5ZPR3, Q9BXR1
    Conserved Domains (2) summary
    smart00410
    Location:156 → 237
    IG_like; Immunoglobulin like
    cl11960
    Location:261 → 357
    Ig; Immunoglobulin domain

  4. XM_047433148.1 → XP_047289104.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q9BXR1

  5. XM_047433147.1 → XP_047289103.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q9BXR1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    71501041..71531847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378932.1 → XP_054234907.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q9BXR1

  2. XM_054378929.1 → XP_054234904.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q9BXR1

  3. XM_054378930.1 → XP_054234905.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q9BXR1

  4. XM_054378931.1 → XP_054234906.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q9BXR1

  5. XM_054378928.1 → XP_054234903.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q9BXR1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZPR3.1 GenPept UniProtKB/Swiss-Prot:Q5ZPR3

Gene LinkOut

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