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CD276 CD276 molecule [ Homo sapiens (human) ]

Gene ID: 80381, updated on 16-Sep-2019

Summary

Official Symbol
CD276provided by HGNC
Official Full Name
CD276 moleculeprovided by HGNC
Primary source
HGNC:HGNC:19137
See related
Ensembl:ENSG00000103855 MIM:605715
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
Summary
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues See more
Orthologs

Genomic context

See CD276 in Genome Data Viewer
Location:
15q24.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (73683966..73714518)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73976560..74006859)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NPTN intronic transcript 1 Neighboring gene neuroplastin Neighboring gene uncharacterized LOC105370891 Neighboring gene Sharpr-MPRA regulatory region 8861 Neighboring gene inhibitory synaptic factor 1 Neighboring gene INSYN1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.
NHGRI GWA Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of immune response NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
CD276 antigen
Names
B7 homolog 3
costimulatory molecule

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051242.1 RefSeqGene

    Range
    5418..35549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024736.2NP_001019907.1  CD276 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_001019907.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK075549, BC062581, CA420873
    Consensus CDS
    CCDS32288.1
    UniProtKB/Swiss-Prot
    Q5ZPR3
    Related
    ENSP00000320084.5, ENST00000318443.10
    Conserved Domains (2) summary
    smart00410
    Location:156237
    IG_like; Immunoglobulin like
    cl11960
    Location:261357
    Ig; Immunoglobulin domain
  2. NM_001329628.2NP_001316557.1  CD276 antigen isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC022188, AC100838, CA420873
    Consensus CDS
    CCDS10251.1
    UniProtKB/Swiss-Prot
    Q5ZPR3
    Related
    ENSP00000454940.1, ENST00000564751.5
  3. NM_001329629.2NP_001316558.1  CD276 antigen isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform a.
    Source sequence(s)
    AK292711, BC011578, BC062581, CA420873
    Consensus CDS
    CCDS86475.1
    UniProtKB/Swiss-Prot
    Q5ZPR3
    UniProtKB/TrEMBL
    A0A0C4DGH0, A8K9J6
    Related
    ENSP00000441087.2, ENST00000537340.6
    Conserved Domains (2) summary
    smart00410
    Location:1091
    IG_like; Immunoglobulin like
    cl11960
    Location:115211
    Ig; Immunoglobulin domain
  4. NM_025240.2NP_079516.1  CD276 antigen isoform b precursor

    See identical proteins and their annotated locations for NP_079516.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AF302102, AK075549, BC062581, CA420873
    Consensus CDS
    CCDS10251.1
    UniProtKB/Swiss-Prot
    Q5ZPR3
    Related
    ENSP00000320058.5, ENST00000318424.9
    Conserved Domains (2) summary
    smart00410
    Location:156238
    IG_like; Immunoglobulin like
    cl11960
    Location:43139
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    73683966..73714518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022638.1XP_016878127.1  CD276 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q5ZPR3
    Conserved Domains (2) summary
    smart00410
    Location:156237
    IG_like; Immunoglobulin like
    cl11960
    Location:261357
    Ig; Immunoglobulin domain
  2. XM_005254700.4XP_005254757.1  CD276 antigen isoform X1

    See identical proteins and their annotated locations for XP_005254757.1

    UniProtKB/Swiss-Prot
    Q5ZPR3
    Conserved Domains (2) summary
    smart00410
    Location:156237
    IG_like; Immunoglobulin like
    cl11960
    Location:261357
    Ig; Immunoglobulin domain
  3. XM_011522095.2XP_011520397.1  CD276 antigen isoform X1

    See identical proteins and their annotated locations for XP_011520397.1

    UniProtKB/Swiss-Prot
    Q5ZPR3
    Conserved Domains (2) summary
    smart00410
    Location:156237
    IG_like; Immunoglobulin like
    cl11960
    Location:261357
    Ig; Immunoglobulin domain
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