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cyp11a1.1 cytochrome P450 family 11 subfamily A member 1, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 80374, updated on 11-Jun-2025
Official Symbol
cyp11a1.1provided by ZNC
Official Full Name
cytochrome P450 family 11 subfamily A member 1, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-010306-1
See related
Ensembl:ENSDARG00000002347 AllianceGenome:ZFIN:ZDB-GENE-010306-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb957; P450scc; cyp11a1; wu:fj97d10
Summary
Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity. Acts upstream of or within several processes, including C21-steroid hormone biosynthetic process; determination of heart left/right asymmetry; and positive regulation of microtubule polymerization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including brain; endocrine system; interrenal primordium; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Jun 2025]
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See cyp11a1.1 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 25 NC_133200.1 (23525942..23541283)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 25 NC_007136.7 (22313602..22335283)

Chromosome 25 - NC_133200.1Genomic Context describing neighboring genes Neighboring gene stomatin (EPB72)-like 1 Neighboring gene cytochrome P450 family 11 subfamily A member 1, tandem duplicate 2 Neighboring gene uncharacterized LOC141380962 Neighboring gene coiled-coil domain containing 33 Neighboring gene uncharacterized LOC137489354

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Expression of zebrafish cyp11a1 as a maternal transcript and in yolk syncytial layer. Hsu HJ, et al. Gene Expr Patterns, 2002 Dec. PMID 12617804
  2. Steroidogenesis in zebrafish and mouse models. Hsu HJ, et al. Mol Cell Endocrinol, 2006 Mar 27. PMID 16356628
  3. Function of Cyp11a1 in animal models. Hu MC, et al. Mol Cell Endocrinol, 2004 Feb 27. PMID 15026180
  4. Zebrafish cyp11a1 and hsd3b genes: structure, expression and steroidogenic development during embryogenesis. Hsu HJ, et al. Mol Cell Endocrinol, 2009 Nov 27. PMID 19682541
  5. Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme cyp11a2. Parajes S, et al. Endocrinology, 2013 Aug. PMID 23671259

See all (160) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression of cyp11a1 during embryogenesis [Review]
    Title: Zebrafish cyp11a1 and hsd3b genes: structure, expression and steroidogenic development during embryogenesis.
  2. The putative promoter of zebrafish cyp11a1, spanning 1.7 kb, was isolated and bioinformatic analysis revealed two conserved FF1 response elements (FREs) that potentially bind Ff1b.
    Title: Transcriptional activation of zebrafish cyp11a1 promoter is dependent on the nuclear receptor Ff1b.
  3. cyp11a1 is expressed in the cytoplasm of oocytes, as a maternal transcript, and in yolk syncytial layer during early embryogenesis
    Title: Expression of zebrafish cyp11a1 as a maternal transcript and in yolk syncytial layer.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC174439

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol monooxygenase (side-chain-cleaving) activity IC
Inferred by Curator
more info
 PubMed 
enables cholesterol monooxygenase (side-chain-cleaving) activity IEA
Inferred from Electronic Annotation
more info
  
enables cholesterol monooxygenase (side-chain-cleaving) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within C21-steroid hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in C21-steroid hormone metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to peptide hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cortisol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epiboly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucocorticoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of microtubule polymerization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to steroid hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
cholesterol side-chain cleavage enzyme, mitochondrial
Names
cytochrome P450, family 11, subfamily A, polypeptide 1
cytochrome P450, subfamily XIA, polypeptide 1
scc
side-chain cleavage enzyme
NP_694485.2
XP_073798484.1
XP_073798485.1
XP_073798486.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152953.2 → NP_694485.2  cholesterol side-chain cleavage enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_694485.2

    Status: PROVISIONAL

    Source sequence(s)
    BC054701
    UniProtKB/TrEMBL
    A0A8M1PBM4, Q7SYJ6
    Related
    ENSDARP00000025030.6, ENSDART00000024866.10
    Conserved Domains (1) summary
    pfam00067
    Location:66 → 502
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133200.1 Reference GRCz12tu Primary Assembly

    Range
    23525942..23541283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073942383.1 → XP_073798484.1  cholesterol side-chain cleavage enzyme, mitochondrial isoform X1

  2. XM_073942384.1 → XP_073798485.1  cholesterol side-chain cleavage enzyme, mitochondrial isoform X1

  3. XM_073942385.1 → XP_073798486.1  cholesterol side-chain cleavage enzyme, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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