Format

Send to:

Choose Destination

COASY Coenzyme A synthase [ Homo sapiens (human) ]

Gene ID: 80347, updated on 5-Jul-2020

Summary

Official Symbol
COASYprovided by HGNC
Official Full Name
Coenzyme A synthaseprovided by HGNC
Primary source
HGNC:HGNC:29932
See related
Ensembl:ENSG00000068120 MIM:609855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBP; DPCK; PPAT; UKR1; NBIA6; PCH12; pOV-2
Summary
Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in kidney (RPKM 20.2), duodenum (RPKM 19.7) and 25 other tissues See more
Orthologs

Genomic context

See COASY in Genome Data Viewer
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42562148..42566277)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40713485..40718299)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene HSD17B1 promoter Neighboring gene uncharacterized LOC108783654 Neighboring gene hydroxysteroid 17-beta dehydrogenase 1 Neighboring gene MAX dimerization protein MLX Neighboring gene PSMC3 interacting protein Neighboring gene reticulophagy regulator family member 3 Neighboring gene tubulin gamma 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of CoA synthase (COASY) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35179

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
dephospho-CoA kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dephospho-CoA kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
dephospho-CoA kinase activity TAS
Traceable Author Statement
more info
 
pantetheine-phosphate adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pantetheine-phosphate adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
pantetheine-phosphate adenylyltransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coenzyme A biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
coenzyme A biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
bifunctional coenzyme A synthase
Names
CoA synthase
bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase
nucleotide binding protein
phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase
NP_001035994.1
NP_001035997.2
NP_079509.5
XP_006722179.1
XP_011523602.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034110.1 RefSeqGene

    Range
    5075..9204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042529.3NP_001035994.1  bifunctional coenzyme A synthase isoform a precursor

    See identical proteins and their annotated locations for NP_001035994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a, also known as CoASy alpha).
    Source sequence(s)
    AK225485, AY094602, DA786254
    Consensus CDS
    CCDS11429.1
    UniProtKB/Swiss-Prot
    Q13057
    Related
    ENSP00000393564.2, ENST00000421097.6
    Conserved Domains (2) summary
    cd02164
    Location:193339
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    cd02022
    Location:360536
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
  2. NM_001042532.4NP_001035997.2  bifunctional coenzyme A synthase isoform c

    See identical proteins and their annotated locations for NP_001035997.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains an additional segment in the 5' coding region, compared to variant 1. The resulting isoform (c, also known as CoASy beta) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK297153, AK314076, BC020985, DA786254
    Consensus CDS
    CCDS45685.1
    UniProtKB/Swiss-Prot
    Q13057
    Related
    ENSP00000464814.1, ENST00000590958.5
    Conserved Domains (3) summary
    cd02164
    Location:222368
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    COG0237
    Location:388588
    CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
    cd02022
    Location:389565
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
  3. NM_025233.7NP_079509.5  bifunctional coenzyme A synthase isoform a precursor

    See identical proteins and their annotated locations for NP_079509.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a (also known as CoASy alpha). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK075415, BC020985, BM781531, DA786254
    Consensus CDS
    CCDS11429.1
    UniProtKB/Swiss-Prot
    Q13057
    Related
    ENSP00000377406.1, ENST00000393818.3
    Conserved Domains (2) summary
    cd02164
    Location:193339
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    cd02022
    Location:360536
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42562148..42566277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525300.2XP_011523602.1  bifunctional coenzyme A synthase isoform X1

    See identical proteins and their annotated locations for XP_011523602.1

    UniProtKB/Swiss-Prot
    Q13057
    Conserved Domains (2) summary
    cd02164
    Location:193339
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    cd02022
    Location:360536
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
  2. XM_006722116.4XP_006722179.1  bifunctional coenzyme A synthase isoform X2

    See identical proteins and their annotated locations for XP_006722179.1

    UniProtKB/Swiss-Prot
    Q13057
    Conserved Domains (3) summary
    cd02164
    Location:222368
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    COG0237
    Location:388588
    CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
    cd02022
    Location:389565
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042530.1: Suppressed sequence

    Description
    NM_001042530.1: This RefSeq was permanently suppressed because currently there is insufficient support for the full-length nature of the transcript.
  2. NM_001042531.1: Suppressed sequence

    Description
    NM_001042531.1: This RefSeq was permanently suppressed because currently there is insufficient support for the protein, and the full-length nature of this transcript variant is unknown.
Support Center