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TRAF3IP3 TRAF3 interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 80342, updated on 31-Dec-2019

Summary

Official Symbol
TRAF3IP3provided by HGNC
Official Full Name
TRAF3 interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:30766
See related
Ensembl:ENSG00000009790 MIM:608255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T3JAM
Summary
The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Biased expression in lymph node (RPKM 18.7), spleen (RPKM 13.0) and 9 other tissues See more
Orthologs

Genomic context

See TRAF3IP3 in Genome Data Viewer
Location:
1q32.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (209756053..209782323)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (209929393..209955668)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene HSD11B1 antisense RNA 1 Neighboring gene hydroxysteroid 11-beta dehydrogenase 1 Neighboring gene adenosine A2b receptor pseudogene 1 Neighboring gene chromosome 1 open reading frame 74 Neighboring gene interferon regulatory factor 6 Neighboring gene VISTA enhancer hs932

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of TRAF3 interacting protein 3 (TRAF3IP3) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44151, MGC117354, MGC163289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TRAF3-interacting JNK-activating modulator
Names
TRAF3 interacting Jun N terminal kinase (JNK) activating modulator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033934.1 RefSeqGene

    Range
    5022..31279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001287754.2NP_001274683.1  TRAF3-interacting JNK-activating modulator isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons, uses an alternate 5'-terminal exon, initiates translation at a downstream start codon, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC110302, BQ277340, BX648450, CB053101
    Consensus CDS
    CCDS73023.1
    UniProtKB/Swiss-Prot
    Q9Y228
    UniProtKB/TrEMBL
    B1AJU2
    Related
    ENSP00000355990.1, ENST00000367023.5
    Conserved Domains (1) summary
    COG4372
    Location:3142
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
  2. NM_001320143.1NP_001307072.1  TRAF3-interacting JNK-activating modulator isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 both encode the same isoform (1).
    Source sequence(s)
    AK122792, AK125601, AL022398, CA436636
    Consensus CDS
    CCDS1490.2
    UniProtKB/Swiss-Prot
    Q9Y228
    UniProtKB/TrEMBL
    B3KWQ9
    Related
    ENSP00000355991.1, ENST00000367024.5
    Conserved Domains (1) summary
    COG1196
    Location:201517
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  3. NM_001320144.2NP_001307073.1  TRAF3-interacting JNK-activating modulator isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL049667, AL558384
    Consensus CDS
    CCDS81422.1
    UniProtKB/Swiss-Prot
    Q9Y228
    Related
    ENSP00000355993.3, ENST00000367026.7
    Conserved Domains (1) summary
    COG1196
    Location:181497
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  4. NM_025228.4NP_079504.2  TRAF3-interacting JNK-activating modulator isoform 1

    See identical proteins and their annotated locations for NP_079504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).
    Source sequence(s)
    AK312755, AL558384, BX648450
    Consensus CDS
    CCDS1490.2
    UniProtKB/Swiss-Prot
    Q9Y228
    Related
    ENSP00000355992.3, ENST00000367025.8
    Conserved Domains (1) summary
    COG1196
    Location:201517
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. NR_109871.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon and its 3'-terminal exon extends past a splice site that is used in variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK312755, AL558384, BC110302, BX648450, CB053101
    Related
    ENST00000478359.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    209756053..209782323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002399.2XP_016857888.1  TRAF3-interacting JNK-activating modulator isoform X1

  2. XM_017002400.2XP_016857889.1  TRAF3-interacting JNK-activating modulator isoform X2

  3. XM_011510019.2XP_011508321.1  TRAF3-interacting JNK-activating modulator isoform X4

  4. XM_011510018.3XP_011508320.1  TRAF3-interacting JNK-activating modulator isoform X3

    Related
    ENSP00000383743.3, ENST00000400959.7
    Conserved Domains (1) summary
    COG1196
    Location:242419
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  5. XM_005273279.5XP_005273336.1  TRAF3-interacting JNK-activating modulator isoform X5

    See identical proteins and their annotated locations for XP_005273336.1

    Conserved Domains (1) summary
    COG4372
    Location:3142
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
  6. XM_024449954.1XP_024305722.1  TRAF3-interacting JNK-activating modulator isoform X6

    Conserved Domains (1) summary
    cl25732
    Location:10245
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_005273280.2XP_005273337.1  TRAF3-interacting JNK-activating modulator isoform X5

    See identical proteins and their annotated locations for XP_005273337.1

    Conserved Domains (1) summary
    COG4372
    Location:3142
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

RNA

  1. XR_247044.3 RNA Sequence

  2. XR_001737440.2 RNA Sequence

  3. XR_001737439.2 RNA Sequence

  4. XR_001737438.2 RNA Sequence

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