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SLC25A16 solute carrier family 25 member 16 [ Homo sapiens (human) ]

Gene ID: 8034, updated on 29-Mar-2020

Summary

Official Symbol
SLC25A16provided by HGNC
Official Full Name
solute carrier family 25 member 16provided by HGNC
Primary source
HGNC:HGNC:10986
See related
Ensembl:ENSG00000122912 MIM:139080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDA; GDC; ML7; hML7; HGT.1; D10S105E
Summary
This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. This gene has a possible role in Graves' disease. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 11.2), prostate (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See SLC25A16 in Genome Data Viewer
Location:
10q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (68477998..68527523, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70242090..70287280, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 29 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene RNA, 5S ribosomal pseudogene 319 Neighboring gene ribosomal protein L26 pseudogene 27 Neighboring gene Sharpr-MPRA regulatory region 5966 Neighboring gene transmembrane protein 14D, pseudogene Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene COX20 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39851

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
antiporter activity NAS
Non-traceable Author Statement
more info
PubMed 
secondary active transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
ATP transport IEA
Inferred from Electronic Annotation
more info
 
coenzyme biosynthetic process TAS
Traceable Author Statement
more info
 
mitochondrial transport NAS
Non-traceable Author Statement
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
graves disease carrier protein
Names
mitochondrial solute carrier protein homolog
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046972.1 RefSeqGene

    Range
    5001..54526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324312.2NP_001311241.1  graves disease carrier protein isoform b

    Status: REVIEWED

    Source sequence(s)
    AK295287, AL136233, AL713888
    UniProtKB/TrEMBL
    B4DHV9
  2. NM_001324313.2NP_001311242.1  graves disease carrier protein isoform c

    Status: REVIEWED

    Source sequence(s)
    AL713888
  3. NM_001324314.2NP_001311243.1  graves disease carrier protein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) and variant 5 both encode the same isoform (d).
    Source sequence(s)
    AL136233, AL713888
    UniProtKB/TrEMBL
    B4DPV4
    Conserved Domains (1) summary
    pfam00153
    Location:33116
    Mito_carr; Mitochondrial carrier protein
  4. NM_001324315.1NP_001311244.1  graves disease carrier protein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) and variant 4 both encode the same isoform (d).
    Source sequence(s)
    AL136233, AL713888
    UniProtKB/TrEMBL
    B4DPV4
    Conserved Domains (1) summary
    pfam00153
    Location:33116
    Mito_carr; Mitochondrial carrier protein
  5. NM_001324317.2NP_001311246.1  graves disease carrier protein isoform e

    Status: REVIEWED

    Source sequence(s)
    AL136233, AL713888
  6. NM_152707.4NP_689920.1  graves disease carrier protein isoform a

    See identical proteins and their annotated locations for NP_689920.1

    Status: REVIEWED

    Source sequence(s)
    AK290255, AL136233, AL713888, BU684567, DA023888
    Consensus CDS
    CCDS7280.1
    UniProtKB/Swiss-Prot
    P16260
    Related
    ENSP00000476815.1, ENST00000609923.6
    Conserved Domains (2) summary
    PTZ00169
    Location:36330
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:33125
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_136737.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136233, AL713888

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    68477998..68527523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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