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PABPC1L poly(A) binding protein cytoplasmic 1 like [ Homo sapiens (human) ]

Gene ID: 80336, updated on 11-Jun-2021

Summary

Official Symbol
PABPC1Lprovided by HGNC
Official Full Name
poly(A) binding protein cytoplasmic 1 likeprovided by HGNC
Primary source
HGNC:HGNC:15797
See related
Ensembl:ENSG00000101104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPAB; PABPC1L1; C20orf119; dJ1069P2.3
Summary
This gene belongs to the polyadenylate-binding protein type-1 family of proteins. Members of this family bind to the polyA tails of mRNAs to regulate mRNA stability and translation. The mouse ortholog of this gene is required for female fertility. In human, expression of a functional protein is regulated by alternative splicing. The protein-coding splice variant for this gene is abundantly expressed in human oocytes, while a noncoding splice variant subject to nonsense-mediated decay is the predominant splice variant expressed in somatic tissues. [provided by RefSeq, Aug 2019]
Expression
Ubiquitous expression in thyroid (RPKM 9.7), lymph node (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See PABPC1L in Genome Data Viewer
Location:
20q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (44910060..44939316)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43538701..43567957)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene piggyBac transposable element derived 4 pseudogene 2 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene STK4 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that PABPC1L gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with PABPC1L PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11840, FLJ30809, FLJ42053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
polyadenylate-binding protein 1-like
Names
embryonic poly(A) binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372179.1NP_001359108.1  polyadenylate-binding protein 1-like

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes the protein. This variant is abundantly expressed in human oocytes.
    Source sequence(s)
    AL008725, AL109839
    Consensus CDS
    CCDS42878.1
    Related
    ENSP00000217073.3, ENST00000217073.7
    Conserved Domains (1) summary
    TIGR01628
    Location:11606
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

RNA

  1. NR_134983.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternate internal splice sites and lacks an internal exon compared to variant 7. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This noncoding splice variant is the predominant transcript expressed in somatic tissues.
    Source sequence(s)
    BM689138, BQ446831, DC418955, DR001377, EU190483
    Related
    ENST00000537323.5
  2. NR_134987.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) retains an alternate intron and includes an alternate exon compared to variant 7. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL008725, AL109839

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    44910060..44939316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001124756.2: Suppressed sequence

    Description
    NM_001124756.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
  2. NR_134984.1: Suppressed sequence

    Description
    NR_134984.1: This RefSeq was removed because the transcript was partial.
  3. NR_134985.1: Suppressed sequence

    Description
    NR_134985.1: This RefSeq was removed because the transcript was partial.
  4. NR_134986.1: Suppressed sequence

    Description
    NR_134986.1: This RefSeq was removed because the transcript was partial.
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