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WDR82 WD repeat domain 82 [ Homo sapiens (human) ]

Gene ID: 80335, updated on 7-Jun-2020

Summary

Official Symbol
WDR82provided by HGNC
Official Full Name
WD repeat domain 82provided by HGNC
Primary source
HGNC:HGNC:28826
See related
Ensembl:ENSG00000164091 MIM:611059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SWD2; MST107; WDR82A; MSTP107; PRO2730; TMEM113; PRO34047
Summary
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in brain (RPKM 35.2), endometrium (RPKM 34.7) and 25 other tissues See more
Orthologs

Genomic context

See WDR82 in Genome Data Viewer
Location:
3p21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (52254424..52278649, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52288438..52312659, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929054 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M Neighboring gene microRNA let-7g Neighboring gene uncharacterized LOC107986086 Neighboring gene GLYCTK antisense RNA 1 Neighboring gene glycerate kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Depletion of WD repeat domain 82 (WDR82) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone methyltransferase activity (H3-K4 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone methyltransferase activity (H3-K4 specific) IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone H3-K4 methylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K4 trimethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
PTW/PP1 phosphatase complex IDA
Inferred from Direct Assay
more info
PubMed 
Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
WD repeat-containing protein 82
Names
transmembrane protein 113

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025222.4NP_079498.2  WD repeat-containing protein 82

    See identical proteins and their annotated locations for NP_079498.2

    Status: VALIDATED

    Source sequence(s)
    AC092045, AI478905, AK098435, AY358264, DB500464
    Consensus CDS
    CCDS2851.2
    UniProtKB/Swiss-Prot
    Q6UXN9
    UniProtKB/TrEMBL
    A0A024R333
    Related
    ENSP00000296490.3, ENST00000296490.8
    Conserved Domains (2) summary
    cd00200
    Location:15300
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2461
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    52254424..52278649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534136.2XP_011532438.1  WD repeat-containing protein 82 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:7223
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:3068
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:7220
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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