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ULBP2 UL16 binding protein 2 [ Homo sapiens (human) ]

Gene ID: 80328, updated on 7-Jun-2020

Summary

Official Symbol
ULBP2provided by HGNC
Official Full Name
UL16 binding protein 2provided by HGNC
Primary source
HGNC:HGNC:14894
See related
Ensembl:ENSG00000131015 MIM:605698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha
Summary
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
Expression
Biased expression in esophagus (RPKM 5.0), lung (RPKM 1.3) and 11 other tissues See more
Orthologs

Genomic context

See ULBP2 in Genome Data Viewer
Location:
6q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149941947..149949235)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150255901..150270371)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RAET1E antisense RNA 1 Neighboring gene retinoic acid early transcript 1G Neighboring gene uncharacterized LOC105378052 Neighboring gene UL16 binding protein 1 Neighboring gene basic transcription factor 3 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 (SF2) Nef downregulates ULBP2; downregulation is dependent upon residues G2 and F195 and a di-lysine motif in Nef as shown in A3.01 T cells and HeLa TZM-bl cells PubMed
nef HIV-1 Nef downregulates cell surface expression of MICA, ULBP1 and ULBP2 in natural killer (NK) cells PubMed
Vif vif HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed
vif A3G upregulates NKG2D ligands through an ATM pathway and in which HIV-1 Vif counteracts this upregulation by decreasing A3G expression PubMed
vif Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
Vpr vpr HIV-1 Vpr from most HIV-1 primary isolates can upregulate ULBP2 expression and induce NKG2D-dependent NK cell killing PubMed
vpr Soluble HIV-1 Vpr promotes cell cycle arrest and upregulates cell-surface expression of ULBP2 in T cells PubMed
vpr HIV-1 Vpr upregulates NKG2D ligands via the ATR pathway PubMed
vpr HIV-1-Vpr induced upregulation of NKG2D ligands in HIV-infected T cells by activating UNG2-dependent repair of uridine-containing DNA PubMed
vpr Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
vpr HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed
vpr Upregulation of NKG2D ligands is dependent on HIV-1 Vpr-mediated activation of the TAR DNA damage/stress pathway, which requires the recruitment of the Cul4/DDB1/DCAF1 E3 ubiquitin ligase complex PubMed
Vpu vpu HIV-1 (NL4-3) Vpu downregulates ULBP2; downregulation is dependent upon amino acids R30/K31, V25/Y29, the acidic di-leucine motif in Vpu helix 2 as shown in A3.01 T cells and HeLa TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
natural killer cell lectin-like receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
natural killer cell activation IDA
Inferred from Direct Assay
more info
PubMed 
natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
UL16-binding protein 2
Names
NKG2D ligand 2
retinoic acid early transcript 1H
retinoic acid early transcript 1L

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025217.4NP_079493.1  UL16-binding protein 2 preproprotein

    See identical proteins and their annotated locations for NP_079493.1

    Status: REVIEWED

    Source sequence(s)
    AL583835, AY358665, BG718474
    Consensus CDS
    CCDS5222.1
    UniProtKB/Swiss-Prot
    Q9BZM5
    Related
    ENSP00000356320.3, ENST00000367351.4
    Conserved Domains (1) summary
    cl08246
    Location:30198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    149941947..149949235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011321.1XP_016866810.1  UL16-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cl08246
    Location:30198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
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