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CEP70 centrosomal protein 70 [ Homo sapiens (human) ]

Gene ID: 80321, updated on 17-Jun-2019

Summary

Official Symbol
CEP70provided by HGNC
Official Full Name
centrosomal protein 70provided by HGNC
Primary source
HGNC:HGNC:29972
See related
Ensembl:ENSG00000114107 MIM:614310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BITE
Expression
Broad expression in testis (RPKM 11.4), duodenum (RPKM 7.8) and 22 other tissues See more
Orthologs

Genomic context

See CEP70 in Genome Data Viewer
Location:
3q22.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (138494339..138594383, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138213186..138313187, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374129 Neighboring gene extended synaptotagmin 3 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene peptidylprolyl isomerase A pseudogene 72

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
    AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
  • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
    Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
  • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
    Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13036

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
centrosomal protein of 70 kDa
Names
centrosomal protein 70kDa
p10-binding protein
testicular tissue protein Li 36

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288964.2NP_001275893.1  centrosomal protein of 70 kDa isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK023098, AK301913, BC030598, BF435951
    Consensus CDS
    CCDS75022.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    Related
    ENSP00000419833.1, ENST00000474781.5
    Conserved Domains (1) summary
    TIGR02169
    Location:67315
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  2. NM_001288965.2NP_001275894.1  centrosomal protein of 70 kDa isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF202146, AK023098, AK299003, BC030598, BF435951, DN993112
    UniProtKB/Swiss-Prot
    Q8NHQ1
    Conserved Domains (1) summary
    TIGR02169
    Location:65313
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  3. NM_001288966.1NP_001275895.1  centrosomal protein of 70 kDa isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a 3' terminal exon that extends past a splice site used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF202146, AF289495, AK225440, DC305447, DN993112
    Consensus CDS
    CCDS75023.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    Related
    ENSP00000417465.1, ENST00000481834.5
    Conserved Domains (1) summary
    TIGR02169
    Location:85477
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  4. NM_001288967.2NP_001275896.1  centrosomal protein of 70 kDa isoform 5

    See identical proteins and their annotated locations for NP_001275896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK023098, AK294587, BC030598, BF435951, DN993112
    Consensus CDS
    CCDS75024.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    UniProtKB/TrEMBL
    B7Z2D2
    Related
    ENSP00000417821.1, ENST00000489254.5
    Conserved Domains (1) summary
    pfam15254
    Location:104177
    CCDC14; Coiled-coil domain-containing protein 14
  5. NM_001320598.2NP_001307527.1  centrosomal protein of 70 kDa isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AC072045, AF202146, AK023098, DC383928
    Consensus CDS
    CCDS3102.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    UniProtKB/TrEMBL
    A0A140VJG2
    Related
    ENSP00000419231.1, ENST00000484888.5
    Conserved Domains (1) summary
    TIGR02169
    Location:85477
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  6. NM_001320599.2NP_001307528.1  centrosomal protein of 70 kDa isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (6) has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC020890, AC072045
    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001320600.1NP_001307529.1  centrosomal protein of 70 kDa isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has a shorter 5' UTR, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (7) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC020890, BC016050
    Consensus CDS
    CCDS82842.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    Related
    ENSP00000419743.1, ENST00000464035.5
    Conserved Domains (1) summary
    COG1196
    Location:15190
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  8. NM_024491.4NP_077817.2  centrosomal protein of 70 kDa isoform 1

    See identical proteins and their annotated locations for NP_077817.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AF202146, AK023098, BC030598, BF435951
    Consensus CDS
    CCDS3102.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    UniProtKB/TrEMBL
    A0A140VJG2
    Related
    ENSP00000264982.3, ENST00000264982.8
    Conserved Domains (1) summary
    TIGR02169
    Location:85477
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    138494339..138594383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007283.1XP_016862772.1  centrosomal protein of 70 kDa isoform X11

  2. XM_017007282.2XP_016862771.1  centrosomal protein of 70 kDa isoform X11

  3. XM_017007284.1XP_016862773.1  centrosomal protein of 70 kDa isoform X11

  4. XM_017007275.1XP_016862764.1  centrosomal protein of 70 kDa isoform X4

    UniProtKB/Swiss-Prot
    Q8NHQ1
    UniProtKB/TrEMBL
    A0A140VJG2
    Conserved Domains (1) summary
    TIGR02169
    Location:85477
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  5. XM_024453781.1XP_024309549.1  centrosomal protein of 70 kDa isoform X3

    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_017007279.1XP_016862768.1  centrosomal protein of 70 kDa isoform X9

  7. XM_017007277.1XP_016862766.1  centrosomal protein of 70 kDa isoform X6

  8. XM_017007280.2XP_016862769.1  centrosomal protein of 70 kDa isoform X10

  9. XM_017007278.2XP_016862767.1  centrosomal protein of 70 kDa isoform X7

  10. XM_017007281.2XP_016862770.1  centrosomal protein of 70 kDa isoform X10

  11. XM_017007276.2XP_016862765.1  centrosomal protein of 70 kDa isoform X5

  12. XM_017007273.1XP_016862762.1  centrosomal protein of 70 kDa isoform X2

  13. XM_017007274.1XP_016862763.1  centrosomal protein of 70 kDa isoform X2

  14. XM_017007271.1XP_016862760.1  centrosomal protein of 70 kDa isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  15. XM_024453780.1XP_024309548.1  centrosomal protein of 70 kDa isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  16. XM_017007272.1XP_016862761.1  centrosomal protein of 70 kDa isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  17. XM_011513209.3XP_011511511.1  centrosomal protein of 70 kDa isoform X8

    Conserved Domains (1) summary
    TIGR02169
    Location:85333
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
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