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CEP70 centrosomal protein 70 [ Homo sapiens (human) ]

Gene ID: 80321, updated on 1-Aug-2020

Summary

Official Symbol
CEP70provided by HGNC
Official Full Name
centrosomal protein 70provided by HGNC
Primary source
HGNC:HGNC:29972
See related
Ensembl:ENSG00000114107 MIM:614310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BITE
Expression
Broad expression in testis (RPKM 11.4), duodenum (RPKM 7.8) and 22 other tissues See more
Orthologs

Genomic context

See CEP70 in Genome Data Viewer
Location:
3q22.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (138494339..138594383, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138213186..138313187, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374129 Neighboring gene extended synaptotagmin 3 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene peptidylprolyl isomerase A pseudogene 72

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13036

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
centrosomal protein of 70 kDa
Names
centrosomal protein 70kDa
p10-binding protein
testicular tissue protein Li 36

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288964.2NP_001275893.1  centrosomal protein of 70 kDa isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK023098, AK301913, BC030598, BF435951
    Consensus CDS
    CCDS75022.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    Related
    ENSP00000419833.1, ENST00000474781.5
    Conserved Domains (1) summary
    TIGR02169
    Location:67315
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  2. NM_001288965.2NP_001275894.1  centrosomal protein of 70 kDa isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF202146, AK023098, AK299003, BC030598, BF435951, DN993112
    UniProtKB/Swiss-Prot
    Q8NHQ1
    Conserved Domains (1) summary
    TIGR02169
    Location:65313
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  3. NM_001288966.1NP_001275895.1  centrosomal protein of 70 kDa isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a 3' terminal exon that extends past a splice site used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF202146, AF289495, AK225440, DC305447, DN993112
    Consensus CDS
    CCDS75023.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    Related
    ENSP00000417465.1, ENST00000481834.5
    Conserved Domains (1) summary
    TIGR02169
    Location:85477
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  4. NM_001288967.2NP_001275896.1  centrosomal protein of 70 kDa isoform 5

    See identical proteins and their annotated locations for NP_001275896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK023098, AK294587, BC030598, BF435951, DN993112
    Consensus CDS
    CCDS75024.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    UniProtKB/TrEMBL
    B7Z2D2
    Related
    ENSP00000417821.1, ENST00000489254.5
    Conserved Domains (1) summary
    pfam15254
    Location:104177
    CCDC14; Coiled-coil domain-containing protein 14
  5. NM_001320598.2NP_001307527.1  centrosomal protein of 70 kDa isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AC072045, AF202146, AK023098, DC383928
    Consensus CDS
    CCDS3102.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    UniProtKB/TrEMBL
    A0A140VJG2
    Related
    ENSP00000419231.1, ENST00000484888.5
    Conserved Domains (1) summary
    TIGR02169
    Location:85477
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  6. NM_001320599.2NP_001307528.1  centrosomal protein of 70 kDa isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (6) has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC020890, AC072045
    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001320600.1NP_001307529.1  centrosomal protein of 70 kDa isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has a shorter 5' UTR, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (7) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC020890, BC016050
    Consensus CDS
    CCDS82842.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    Related
    ENSP00000419743.1, ENST00000464035.5
    Conserved Domains (1) summary
    COG1196
    Location:15190
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  8. NM_024491.4NP_077817.2  centrosomal protein of 70 kDa isoform 1

    See identical proteins and their annotated locations for NP_077817.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AF202146, AK023098, BC030598, BF435951
    Consensus CDS
    CCDS3102.1
    UniProtKB/Swiss-Prot
    Q8NHQ1
    UniProtKB/TrEMBL
    A0A140VJG2
    Related
    ENSP00000264982.3, ENST00000264982.8
    Conserved Domains (1) summary
    TIGR02169
    Location:85477
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    138494339..138594383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007283.1XP_016862772.1  centrosomal protein of 70 kDa isoform X11

  2. XM_017007282.2XP_016862771.1  centrosomal protein of 70 kDa isoform X11

  3. XM_017007284.1XP_016862773.1  centrosomal protein of 70 kDa isoform X11

  4. XM_017007275.1XP_016862764.1  centrosomal protein of 70 kDa isoform X4

    UniProtKB/Swiss-Prot
    Q8NHQ1
    UniProtKB/TrEMBL
    A0A140VJG2
    Conserved Domains (1) summary
    TIGR02169
    Location:85477
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  5. XM_024453781.1XP_024309549.1  centrosomal protein of 70 kDa isoform X3

    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_017007279.1XP_016862768.1  centrosomal protein of 70 kDa isoform X9

  7. XM_017007277.1XP_016862766.1  centrosomal protein of 70 kDa isoform X6

  8. XM_017007280.2XP_016862769.1  centrosomal protein of 70 kDa isoform X10

  9. XM_017007278.2XP_016862767.1  centrosomal protein of 70 kDa isoform X7

  10. XM_017007281.2XP_016862770.1  centrosomal protein of 70 kDa isoform X10

  11. XM_017007276.2XP_016862765.1  centrosomal protein of 70 kDa isoform X5

  12. XM_017007273.1XP_016862762.1  centrosomal protein of 70 kDa isoform X2

  13. XM_017007274.1XP_016862763.1  centrosomal protein of 70 kDa isoform X2

  14. XM_017007271.1XP_016862760.1  centrosomal protein of 70 kDa isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  15. XM_024453780.1XP_024309548.1  centrosomal protein of 70 kDa isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  16. XM_017007272.1XP_016862761.1  centrosomal protein of 70 kDa isoform X1

    Conserved Domains (1) summary
    cl25732
    Location:85477
    SMC_N; RecF/RecN/SMC N terminal domain
  17. XM_011513209.3XP_011511511.1  centrosomal protein of 70 kDa isoform X8

    Conserved Domains (1) summary
    TIGR02169
    Location:85333
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
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